Relationship between resting-state theta phase-gamma amplitude coupling and neurocognitive functioning in patients with first-episode psychosis

Lee, Tak Hyung; Kim, Minah; Hwang, Wu Jeong; Kim, Taekwan; Kwak, Yoo Bin; Kwon, Jun Soo

doi:10.1016/j.schres.2019.12.010

Cited by 15 publications

(15 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These studies found a decrease of theta activity specifically in the anterior regions in FEP ( 89 ) and FES subjects ( 78 ) as compared to HCs. Furthermore, a complex LORETA study investigating theta-gamma amplitude phase coupling (regulation of the gamma band activity depending on the phase of theta band activity) showed an alteration in this index in a FES sample in the posterior cingulate cortex ( 90 ). Some studies investigated the neural connectivity during resting-state and found a decrease in the global field synchronization ( 74 ), or an increase in the synchronization between posterior cingulate cortex, cuneus, and precuneus ( 80 ) or an increased connectivity between brain networks ( 91 – 93 ) in the theta band in FES subjects, as compared to HCs.…”

Section: Resultsmentioning

confidence: 99%

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Introduction: Electrophysiological (EEG) abnormalities in subjects with schizophrenia have been largely reported. In the last decades, research has shifted to the identification of electrophysiological alterations in the prodromal and early phases of the disorder, focusing on the prediction of clinical and functional outcome. The identification of neuronal aberrations in subjects with a first episode of psychosis (FEP) and in those at ultra high-risk (UHR) or clinical high-risk (CHR) to develop a psychosis is crucial to implement adequate interventions, reduce the rate of transition to psychosis, as well as the risk of irreversible functioning impairment. The aim of the review is to provide an up-to-date synthesis of the electrophysiological findings in the at-risk mental state and early stages of schizophrenia.Methods: A systematic review of English articles using Pubmed, Scopus, and PsychINFO was undertaken in July 2020. Additional studies were identified by hand-search. Electrophysiological studies that included at least one group of FEP or subjects at risk to develop psychosis, compared to healthy controls (HCs), were considered. The heterogeneity of the studies prevented a quantitative synthesis.Results: Out of 319 records screened, 133 studies were included in a final qualitative synthesis. Included studies were mainly carried out using frequency analysis, microstates and event-related potentials. The most common findings included an increase in delta and gamma power, an impairment in sensory gating assessed through P50 and N100 and a reduction of Mismatch Negativity and P300 amplitude in at-risk mental state and early stages of schizophrenia. Progressive changes in some of these electrophysiological measures were associated with transition to psychosis and disease course. Heterogeneous data have been reported for indices evaluating synchrony, connectivity, and evoked-responses in different frequency bands.Conclusions: Multiple EEG-indices were altered during at-risk mental state and early stages of schizophrenia, supporting the hypothesis that cerebral network dysfunctions appear already before the onset of the disorder. Some of these alterations demonstrated association with transition to psychosis or poor functional outcome. However, heterogeneity in subjects' inclusion criteria, clinical measures and electrophysiological methods prevents drawing solid conclusions. Large prospective studies are needed to consolidate findings concerning electrophysiological markers of clinical and functional outcome.

show abstract

Section: Resultsmentioning

confidence: 99%

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The most actively studied PAC is TGC, which is closely related to general cognitive functions, including working memory [ 41 , 42 ], language [ 43 ], and attention [ 44 ]. In particular, the increase in resting TGC in patients with schizophrenia is associated with dysfunction of the default mode network [ 45 , 46 ] and has been actively studied.…”

Section: Diagnosismentioning

confidence: 99%

The Role of Quantitative Electroencephalogram in the Diagnosis and Subgrouping of Attention-Deficit/Hyperactivity Disorder

Bong

Kim

2021

J Korean Acad Child Adolesc Psychiatry

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder (ADHD) leads to functional decline in academic performance, interpersonal relationships, and development in school-aged children. Early diagnosis and appropriate intervention can significantly reduce the functional decline caused by ADHD. Currently, there is no established biological marker for ADHD. Some studies have suggested that various indicators from the quantitative electroencephalogram (QEEG) may be useful biological markers for the diagnosis of ADHD. Until the 2010s, theta/beta ratio (TBR) was a biomarker candidate for ADHD that consistently showed high diagnostic value. However, limitations of TBR have recently been reported. Studies have demonstrated that phase-amplitude coupling, especially theta phase-gamma amplitude coupling, are related to cognitive dysfunction and may assist in the diagnosis of ADHD. As yet, the underlying mechanism is not clearly established, and the clinical efficacy of these biomarkers needs to be proven through well-controlled studies. Based on the heterogeneous characteristics of ADHD, subgrouping through QEEG plays a key role in diagnosis and treatment planning. Sophisticated, welldesigned studies and meta-analyses are necessary to confirm these findings.

show abstract

“…In schizophrenia patients, a previous resting-state EEG study from Hirano et al did not detect abnormality in theta phase-gamma amplitude coupling, 42 while two recent studies from Won et al and Lee et al found increased theta phase-gamma amplitude coupling. 40,41 Since the current analysis did not include gamma amplitude as a scalar, results cannot be directly compared. It is notable, however, that the age, chronicity, and sample size may also contribute to the discrepancy of results across studies.…”

Section: Discussionmentioning

confidence: 99%

“…Schizophrenia patients showed normal theta phase-gamma amplitude coupling during an auditory steady-state response (ASSR) task where gamma-band activity was driven via 40-Hz stimulation. 38,39 In resting-state EEG studies, two recent studies found that theta phase-gamma amplitude coupling was increased in schizophrenia patients relative to healthy comparison subjects, 40,41 but one study failed to detect abnormal theta phase-gamma amplitude coupling. 42 By contrast, theta phase-gamma amplitude coupling PCN Psychiatry and Clinical Neurosciences during working memory performance was decreased in patients with schizophrenia.…”

mentioning

confidence: 99%

High‐power gamma‐related delta phase alteration in schizophrenia patients at rest

Koshiyama

Miyakoshi

Tanaka‐Koshiyama

et al. 2022

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Aim Information processing is supported by the cortico‐cortical transmission of neural oscillations across brain regions. Recent studies have demonstrated that the rhythmic firing of neural populations is not random but is governed by interactions with other frequency bands. Specifically, the amplitude of gamma‐band oscillations is associated with the phase of lower frequency oscillations in support of short and long‐range communications among networks. This cross‐frequency relation is thought to reflect the temporal coordination of neural communication. While schizophrenia patients show abnormal oscillatory responses across multiple frequencies at rest, it is unclear whether the functional relationships among frequency bands are intact. This study aimed to characterize the lower frequency (delta/theta, 1–8 Hz) phase and the amplitude of gamma oscillations in healthy subjects and schizophrenia patients at rest. Methods Low frequency‐phase (delta‐ and theta‐ band) angles and gamma‐band amplitude relationships were assessed in 142 schizophrenia patients and 128 healthy subjects. Results Significant low‐frequency phase alteration related to high‐power gamma was detected across broadly distributed scalp regions in both healthy subjects and patients. In patients, delta phase synchronization related to high‐power gamma was significantly decreased at the frontocentral, right middle temporal, and left temporoparietal electrodes but significantly increased at the left parietal electrode. Conclusions High‐power gamma‐related delta phase alteration may reflect a core pathophysiologic abnormality in schizophrenia. Data‐driven measures of functional relationships among frequency bands may prove useful in the development of novel therapeutics. Future studies are needed to determine whether these alterations are specific to schizophrenia or appear in other neuropsychiatric patient populations.

show abstract

Relationship between resting-state theta phase-gamma amplitude coupling and neurocognitive functioning in patients with first-episode psychosis

Cited by 15 publications

References 55 publications

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

The Role of Quantitative Electroencephalogram in the Diagnosis and Subgrouping of Attention-Deficit/Hyperactivity Disorder

High‐power gamma‐related delta phase alteration in schizophrenia patients at rest

Contact Info

Product

Resources

About