Relationship between rheumatoid arthritis activity and antithyroid antibodies

Koszarny, Arkadiusz; Majdan, Maria; Suszek, Dorota; Wielosz, Ewa; Dryglewska, Magdalena

doi:10.20452/pamw.1829

Cited by 25 publications

(32 citation statements)

References 9 publications

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“…Nevertheless, it is possible that patients with persistently elevated antithyroid antibodies will progress to thyroid disease in the future, considering that these may be found in serum many years before the disease appears. 35 A profile similar to SLE was found in SSc patients, with higher prevalence of thyroid autoantibodies with or without hypothyroidism than in controls. SSc patients showed a higher odds ratio for the presence of antithyroid antibodies.…”

Section: Discussionmentioning

confidence: 62%

“…46 However, another research group described thyroid autoantibodies as being more common in RA patients with high disease activity, as measured through DAS 28, anemia and seropositivity. 35 We found a tendency towards an association for TPO antibodies and hypothyroidism with disease activity. However, judging disease activity in RA through instruments that use tender and swollen joint counts, such as DAS-28, may be misleading in this context.…”

Section: Discussionmentioning

confidence: 63%

“…As already mentioned, patients with persistent autoantibody positivity, especially anti-TPO, may develop thyroid disease in the future. 35 Also, the study design did not allow us to prove any causal association. Likewise, we were unable to determine what influence antirheumatic immunosuppressive drug treatment has on antibody positivity.…”

Section: Discussionmentioning

confidence: 99%

“…35 Others noted that RA patients who were positive for TPO antibodies showed greater progression of carotid intima media thickness, thus suggesting that this antibody may amplify the cardiovascular risk in this disease. 46 However, another research group described thyroid autoantibodies as being more common in RA patients with high disease activity, as measured through DAS 28, anemia and seropositivity.…”

Section: Discussionmentioning

confidence: 99%

“…2 Arthralgia and even arthritis of small joints such as the wrist and hand are found in patients with thyroid autoimmunity without concomitant connective tissue disease. 7,35 Punzi et al 47 observed antimicrosomal antibodies in the synovial fluid of patients one year prior to antibody detection in serum, and one year prior to the diagnosis of hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

et al. 2017

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BACKGROUND: Thyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients' geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of patients with systemic rheumatic disease and the degree of association between its presence and inflammatory activity. DESIGN AND SETTING: Cross-sectional observational study in a rheumatology unit. METHODS: 301 patients with systemic lupus erythematosus (SLE), 210 with rheumatoid arthritis (RA), 58 with scleroderma (SSc) and 80 with spondyloarthritis (SpA) were studied regarding thyroid function (TSH and T4), anti-thyroglobulin (TgAb) and anti-thyroperoxidase (TPOab) and compared with 141 healthy controls. Disease activity in patients with rheumatic disease was assessed through appropriate indexes. RESULTS: There were more antithyroid antibodies in SLE patients with hypothyroidism (P = 0.01; odds ratio, OR 2.7; 95% confidence interval, CI: 1.20-6.26) and in those without hypothyroidism (P = 0.06; OR 2.4; 95% CI: 1.28-4.55) than in controls. SSc patients also showed P = 0.03 both with antithyroid antibodies and hypothyroidism (OR 3.4; 95% CI: 1.06-10.80) and without hypothyroidism (OR 3.1; 95% CI: 1.11-0.13). RA and SpA patients had the same prevalence as controls (P not significant). Presence of autoantibodies with and without hypothyroidism was not associated with the activity or functional indexes evaluated. CONCLUSION: SLE and SSc were associated with higher prevalence of thyroid autoantibodies in patients with and without hypothyroidism, unlike SpA and RA. There was no link between thyroid autoantibody presence and disease activity or functional impairment.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%