Relationship between right ventricular dilatation and blood copeptin levels in patients with acute pulmonary embolism

Abstract

In this study, we aimed to investigate the importance of copeptin in the diagnosis of acute pulmonary embolism, detection of right ventricular dilatation and clinical severity and prognosis of pulmonary embolism. Materials and Methods: In the study three groups were created; Group 1: Pulmonary embolism patients with right ventricular dilatation in echocardiography, Group 2: Pulmonary embolism patients without right ventricular dilatation in echocardiography, Group 3: Healthy people. Five mL of venous blood was collected for the measurement of serum copeptin from the patients and control group. D-dimer and troponin were studied with routine blood samples. Complaints, symptom and physical examination findings, tomography and echocardiography results, laboratory results of patients and treatments they received were recorded for the statistical analysis. Results: Copeptin levels of acute pulmonary embolism patients were significantly higher than healthy individuals (P < 0.001). Copeptin values of Group 1 patients were significantly higher than Group 2 patients and Group 3 patients (P < 0.001). There was a statistically significant difference the levels of copeptin, D-dimer and troponin between patients with right ventricular dilatation and patients without right ventricular dilatation (P < 0.05). AUC value in detecting right ventricular dilatation of copeptin was found to be 0.82, while specificity was 83.3% and sensitivity was 69.6%. Copeptin, D-dimer and troponin levels of patients with increased pulmonary artery pressure were statistically significantly higher than patients with normal pulmonary artery pressure (P < 0.05). Conclusion: Copeptin can be used in the diagnosis of acute pulmonary embolism and in the detection of right ventricular dilatation in pulmonary embolism. K E Y W O R D S biomarker, echocardiography, heart failure, prognosis, pulmonary embolism 1 | INTRODUCTION Pulmonary embolism (PE) is a common life-threatening cardiopulmonary disorder in which a venous thrombus obstructs pulmonary arterial bed. 1,2 The obstruction of pulmonary arterial bed may cause acute but reversible right ventricular failure. 1,2 Right ventricular dysfunction is an important prognostic value in patients with PE. In patients with right How to cite this article: Usul E, Ozkan S, Höke MH, Kaya AE, Ucar F, Cimen T. Relationship between right ventricular dilatation and blood copeptin levels in patients with acute pulmonary embolism.

Pulmonary Embolism Risk Assessment Using Blood Copeptin Concentration and Pulmonary Arteries Thrombotic Burden Evaluated by Computer Tomography

“…Multiple studies have also validated these imagistic parameters as predictors for the clinical outcome of PE patients [9,35]. Our results are in accord with previous papers where copeptin was correlated with both paraclinical and imagistic markers of PE severity [14,19,31].…”

“…The acute PE population in our study presented with a risk profile and mortality which was comparable to that in previously reported papers [31], thus enabling us to examine the role of copeptin and the Mastora score for prognostic assessment of PE. In the present research, copeptin levels were statistically significantly higher in each risk category of PE patients, starting with low risk and up to high risk.…”

Brain-Derived Neurotrophic Factor Expression in Patients with Acute Pulmonary Embolism Compared to the General Population: Diagnostic and Prognostic Implications

“…The overall risk profile and mortality in our study population were similar with previous observational studies focusing on acute PE [ 16 , 17 ]. This allowed us to examine if BDNF levels may be used as predictors for PE evolution by comparing parameters already validated for risk stratification.…”