Relationship between serine dipeptide lipids of commensal Bacteroidetes and atherosclerosis

Olsen, Ingar

doi:10.1080/20002297.2018.1453224

Cited by 8 publications

(8 citation statements)

References 24 publications

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“…Notably, it was recently reported that some of these glycine lipids are found in human serum, brain, and carotid artery atheroma (14). Due to the localization of these lipids in atherosclerotic lesions and signaling through inflammatory TLRs, it is thought that these bacterial-derived lipids may contribute to the pathogenesis of atherosclerosis (9,14). Furthermore, it seems plausible that dietary factors known to influence Bacteroidetes relative abundance (e.g., dietary fat) may influence host exposure to these bacterial glycine lipids.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…Lower microbial diversity and a higher Firmicutes/Bacteroidetes ratio often characterize the gut dysbiosis seen in high-fat diet (HFD)-induced obesity and metabolic diseases (4)(5)(6)(7)(8). Even though a higher prevalence of Bacteroidetes appears to be associated with beneficial health outcomes, some species of the phylum, such as Porphyromonous gingivalis, can invade the endothelial layer of arteries and translocate to the circulatory system, allowing for potential inflammatory signaling (9). Alongside changes in gut microbiota composition and translocation of whole microbes, exposure to microbiota-produced metabolites and bioactive compounds may also drive disease development.…”

Section: Introductionmentioning

confidence: 99%

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Gut microbiome-derived glycine lipids are diet-dependent modulators of hepatic injury and atherosclerosis

Millar

Anto

García

et al. 2022

Journal of Lipid Research

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gut microbiome-derived glycine lipids are diet-dependent modulators of hepatic injury and atherosclerosis

Millar

Anto

García

et al. 2022

Journal of Lipid Research

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“…thetaiotaomicron are known to synthesize several classes of dihydroceramides (DHC) and galactosylceramides . The serine dipeptide lipids produced by common oral and intestinal Bacteroidetes bacteria play important roles in promoting atherosclerosis. , The genetic requirements for the biosynthesis of glycine lipid (GL), a diacylated amino acid species, are known to have contributed to fitness in the human gut bacterium B. thetaiotaomicron .…”

Section: Introductionmentioning

confidence: 99%

Lipidome of the Bacteroides Genus Containing New Peptidolipid and Sphingolipid Families Revealed by Multiple-Stage Mass Spectrometry

et al. 2023

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The anaerobic bacteria of the Bacteroides fragilis group including Bacteroides thetaiotaomicron, B. fragilis, Bacteroides vulgatus, and Bacteroides ovatus in genus Bacteroides are among the most commonly found human gut microbiota. They are generally commensal but are also opportunistic pathogens. Both the inner and outer membranes of the Bacteroides cell envelope contain abundant lipids with diversified structures, and dissection of the lipid composition of the inner and outer membrane fractions is important for understanding the biogenesis of this multilaminate wall structure. Here, we describe mass spectrometry-based approaches to delineate in detail the lipidome of the membrane and the outer membrane vesicle of the bacteria cells. We identified 15 lipid class/subclasses (>100 molecular species), including sphingolipid families [dihydroceramide (DHC), glycylseryl (GS) DHC, DHC-phosphoinositolphosphoryl-DHC (DHC-PIP-DHC), ethanolamine phosphorylceramide, inositol phosphorylceramide (IPC), serine phosphorylceramide, ceramide-1-phosphate, and glycosyl ceramide], phospholipids [phosphatidylethanolamine, phosphatidylinositol (PI), and phosphatidylserine], peptide lipids (GS-, S-, and G-lipids) and cholesterol sulfate, of which several have not been reported previously, or have similar structures to those found in Porphyromonas gingivalis, the periodontopathic bacterium in oral microbiota. The new DHC-PIPs-DHC lipid family is found only in B. vulgatus, which, however, lacks the PI lipid family. The galactosyl ceramide family is exclusively present in B. fragilis, which nevertheless lacks IPC and PI lipids. The lipidomes as revealed in this study demonstrate the lipid diversity among the various strains and the utility of multiple-stage mass spectrometry (MS n ) with high-resolution mass spectrometry in the structural elucidation of complex lipids.

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“…Despite the production and release of various inflammatory mediators, in the active phase of periodontal disease, tissue destruction occurs mainly due to an imbalance between the level of matrix metalloproteinases and their endogenous inhibitors [13]. Subsequently, through the stimulation of certain pro-inflammatory cytokines, such as interleukin (IL)-1b, IL-6, tumor necrosis factor and (TNF)-α, inflammatory infiltrates from periodontal tissues initiate tissue and alveolar bone destruction [7,[13][14][15][16][17][18][19][20]. During periodontitis, activated osteoclasts and inflammatory-related mediators can control the release of ligand-receptor factor kappa B (NF-κB), receptor activator of nuclear factor kappa-B ligand (RANKL), and osteoprotegerin (OPG), which activates the osteoclast receptor and the relative alveolar bone destruction [21].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic and Metagenomic Potential of the Biomolecular Therapies against Periodontitis and the Oral Microbiome: Current Evidence and Future Perspectives

Santonocito

Ferlito

Polizzi

et al. 2022

IJMS

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The principles of periodontal therapy are based on the control of microbial pathogens and host factors that contribute to biofilm dysbiosis, with the aim of modulating the progression of periodontitis and periodontal tissue destruction. It is currently known how differently each individual responds to periodontal treatment, depending on both the bacterial subtypes that make up the dysbiotic biofilm and interindividual variations in the host inflammatory response. This has allowed the current variety of approaches for the management of periodontitis to be updated by defining the goals of target strategies, which consist of reducing the periodontopathogenic microbial flora and/or modulating the host-mediated response. Therefore, this review aims to update the current variety of approaches for the management of periodontitis based on recent target therapies. Recently, encouraging results have been obtained from several studies exploring the effects of some targeted therapies in the medium- and long-term. Among the most promising target therapies analyzed and explored in this review include: cell-based periodontal regeneration, mediators against bone resorption, emdogain (EMD), platelet-rich plasma, and growth factors. The reviewed evidence supports the hypothesis that the therapeutic combination of epigenetic modifications of periodontal tissues, interacting with the dysbiotic biofilm, is a key step in significantly reducing the development and progression of disease in periodontal patients and improving the therapeutic response of periodontal patients. However, although studies indicate promising results, these need to be further expanded and studied to truly realize the benefits that targeted therapies could bring in the treatment of periodontitis.

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Relationship between serine dipeptide lipids of commensal Bacteroidetes and atherosclerosis

Cited by 8 publications

References 24 publications

Gut microbiome-derived glycine lipids are diet-dependent modulators of hepatic injury and atherosclerosis

Gut microbiome-derived glycine lipids are diet-dependent modulators of hepatic injury and atherosclerosis

Lipidome of the Bacteroides Genus Containing New Peptidolipid and Sphingolipid Families Revealed by Multiple-Stage Mass Spectrometry

Therapeutic and Metagenomic Potential of the Biomolecular Therapies against Periodontitis and the Oral Microbiome: Current Evidence and Future Perspectives

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