Relationship between serum Betatrophin, GPIHBP1, and LDL subfractions in patients with gestational diabetes mellitus

Saruhan, Ercan; İspir, Emre

doi:10.1016/j.clinbiochem.2023.110592

Cited by 1 publication

(1 citation statement)

References 34 publications

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“…In a recent prospective case-control study involving 41 pregnant women with and without gestational diabetes mellitus (GDM), serum levels of LDL6 subfraction, betatrophin, and the potent LPL activator glycosylphosphatidylinositolanchored high-density lipoprotein-binding protein 1 were found to be higher in the GDM group compared to the controls, which may be part of an adaptive mechanism in response to insulin resistance. However, significant correlations between LDL subfractions and betatrophin were not detected [16].…”

Section: Introductionmentioning

confidence: 97%

Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients

Lőrincz,

Csiha,

Ratku

et al. 2023

IJMS

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Betatrophin, also known as angiopoietin-like protein 8 (ANGPTL8), mainly plays a role in lipid metabolism. To date, associations between betatrophin and lipoprotein subfractions are poorly investigated. For this study, 50 obese patients with type 2 diabetes (T2D) and 70 nondiabetic obese (NDO) subjects matched in gender, age, and body mass index (BMI) as well as 49 gender- and age-matched healthy, normal-weight controls were enrolled. Serum betatrophin levels were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Betatrophin concentrations were found to be significantly higher in the T2D and NDO groups compared to the controls in all subjects and in females, but not in males. We found significant positive correlations between triglyceride, very low density lipoprotein (VLDL), large LDL (low density lipoprotein), small LDL, high density lipoprotein (HDL) -6-10 subfractions, and betatrophin, while negative correlations were detected between betatrophin and IDL, mean LDL size, and HDL-1-5. Proportion of small HDL was the best predictor of betatrophin in all subjects. Small LDL and large HDL subfractions were found to be the best predictors in females, while in males, VLDL was found to be the best predictor of betatrophin. Our results underline the significance of serum betatrophin measurement in the cardiovascular risk assessment of obese patients with and without T2D, but gender differences might be taken into consideration.

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Section: Introductionmentioning

confidence: 97%