Relationship between serum concetrations of type III procollagen, hyluronic acid and histopathological findings in the liver of HCV-positive blood donors

Camacho, Vera Regina Rodrigues; Silveira, Themis Reverbel da; Oliveira, Jarbas Rodrigues de; Barros, Sérgio Gabriel Silva de; Cerski, Carlos Thadeu Schmidt

doi:10.1590/s0004-28032007000200006

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Thus, circulating levels of PIIINP can be a biomarker of hepatic fibrogenesis [27,28]. In some observational studies, plasma PIIINP levels have been shown to be strongly associated with liver fibrosis in patients with chronic liver disease [29][30][31][32]. The best predictive value was reported, with an AUROC = 0.87 distinguishing fibrosis and cirrhosis from normal liver or steatosis in 45 cases with alcoholic liver disease [31].…”

Section: Discussionmentioning

confidence: 99%

Nomogram for predicting advanced liver fibrosis and cirrhosis in patients with chronic liver disease

et al. 2021

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Background We aimed to formulate a novel predictive nomogram to discriminate liver fibrosis stage in patients with chronic liver disease. Methods Nomograms were established based on the results of multivariate analysis. The predictive accuracy of the nomograms was assessed by ROC analysis and calibration. Decision curve analysis (DCA) was used to determine the clinical benefit of the nomograms. Results INR, platelets, and N-terminal propeptide type III collagen (PIIINP) were independent predictors for advanced liver fibrosis (≥ S3) and cirrhosis (S4) in patients with chronic liver disease in the training cohort. In the training set, the areas under the ROCs (AUROCs) of nomogram S3S4, APRI, FIB-4, and GPR for stage ≥ S3 were 0.83, 0.71, 0.68, and 0.74, respectively; the AUROCs of nomogram S4, APRI, FIB-4, and GPR for stage S4 were 0.88, 0.74, 0.78, and 0.79, respectively. The calibrations showed optimal agreement between the prediction by the established nomograms and actual observation. In the validation set, the AUROCs of nomogram S3S4, APRI, FIB-4, and GPR for stage ≥ S3 were 0.86, 0.79, 0.78, and 0.81, respectively; the AUROCs of nomogram S4, APRI, FIB-4, and GPR for stage S4 were 0.88, 0.77, 0.81, and 0.83, respectively. Furthermore, the decision curve analysis suggested that the nomograms represent better clinical benefits in both independent cohorts than APRI, FIB-4, and GPR. Conclusion The constructed nomograms could be a superior tool for discriminating advanced fibrosis and cirrhosis in chronic liver disease.

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Section: Discussionmentioning

confidence: 99%

Nomogram for predicting advanced liver fibrosis and cirrhosis in patients with chronic liver disease

et al. 2021

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“…Continued serum measurements of AST, alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) have been used to monitor patients [10][11][12]. In addition to these markers, some ECM components, such as procollagen type III, laminin, and hyaluronic acid (HA), have been used as biomarkers to predict liver fibrosis [13][14][15]. In HCV patients, the increase in serum HA is associated with the development of hepatic fibrosis and disease progression [16].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of Serum Hyaluronan for Detecting HCV Infection and Liver Fibrosis in Asymptomatic Blood Donors

et al. 2021

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Background: The disease caused by hepatitis C virus (HCV) is asymptomatic, silent, and progressive liver disease. In HCV-infected patients the increase in serum HA is associated with the development of hepatic fibrosis and disease progression. Methods: HCV-RNA detection was performed in all serological samples of blood donors that tested positive using HCV Ultra ELISA. Determination of hyaluronan (HA) was performed in positive HCV samples using ELISA-like fluorometric method. The HA content was compared to HCV viral load, genotype of the virus, liver fibrosis as well as ALT and GGT liver biomarkers. Results: Persistently normal ALT (<40 U/L) and GGT (<50 U/L) serum levels were detected in 75% and 69% of the HCV-Infected blood donors, respectively. Based on ROC analysis, the HA value < 34.2 ng/mL is an optimal cut-off point to exclude HCV viremia (specificity = 91%, NPV = 99%). Applying HA value ≥34.2 ng/mL significant liver fibrosis (≥F2) can be estimated in 46% of the HCV-infected blood donors. HA serum level (≥34.2 ng/mL) associated with a high ALT level (>40 U/mL) can correctly identify HCV infection and probable liver fibrosis (sensitivity = 96% and specificity = 90%) in asymptomatic blood donors. Conclusions: A high level of HA (≥34.2 ng/mL) in association with ALT (≥40 U/L) in serum can provide a good clinical opportunity to detect HCV-infected asymptomatic persons that potentially require a liver biopsy confirmation and antiviral treatment to prevent the development of advanced liver fibrosis or cirrhosis.

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The Liver

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Relationship between serum concetrations of type III procollagen, hyluronic acid and histopathological findings in the liver of HCV-positive blood donors

Cited by 5 publications

References 25 publications

Nomogram for predicting advanced liver fibrosis and cirrhosis in patients with chronic liver disease

Nomogram for predicting advanced liver fibrosis and cirrhosis in patients with chronic liver disease

Diagnostic Accuracy of Serum Hyaluronan for Detecting HCV Infection and Liver Fibrosis in Asymptomatic Blood Donors

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