Relationship between Serum Levels of Some Trace Elements, Disease Duration and Severity in Patients with Knee Osteoarthritis

Mahmood, Naza Mohammad Ali

doi:10.4236/pp.2015.611051

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…One of the potential reasons for us noting a lower copper concentration in the degenerated intervertebral discs compared to the healthy ones is the fact that the group of patients in the study group was treated for a long time pharmacologically, using non-steroidal anti-inflammatory drugs and rehabilitation, which could lead to a reduction in the lipid peroxidation and systemic oxidative stress [ 28 ]. It cannot be ruled out that the collection of copper concentration results, other than those previously recorded in degenerated intervertebral discs by Kubaszewski et al [ 26 ], and inconsistent with the observations of Mahmood et al [ 29 ], who indicated a higher concentration of copper in patients with knee osteoarthritis, depending on age and the duration of the disease, may be related to the fact that we assessed the concentration of elements in material that was not composed of bone or cartilage tissue [ 29 ]. We also did not indicate a statistically significant relationship between the concentrations of zinc and copper.…”

Section: Discussioncontrasting

confidence: 61%

Changes in Elements and Relationships among Elements in Intervertebral Disc Degeneration

Staszkiewicz

Bryś²,

Gładysz

et al. 2022

IJERPH

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Intervertebral disc degeneration (IVDD) is a complex and progressive process of disc aging. One of the most important causes of changes in the internal environment, leading to IVDD, can be changes in the concentration of individual metal elements. This study aimed to analyze the concentrations of copper, iron, manganese, lead, zinc, sodium, potassium, phosphorus, and calcium in the degenerated intervertebral discs of the lumbosacral spine, compared to healthy intervertebral discs. The study group (S) consisted of 113 Caucasian patients, qualified by a specialist surgeon for IVDD of the lumbosacral spine. The control group (C) consisted of 81 individuals. The biological material was obtained from Caucasian human cadavers during post-mortem examination. The concentrations of individual elements were assessed using inductively coupled plasma–optical emission spectroscopy (ICP-OES). Statistically significant differences in the concentrations of microelements, depending on the degree of pain intensity, were noted for only potassium (p < 0.05). Statistically significant differences in the concentrations of the assessed microelements, depending on the degree of radiological advancement of the lesions, were noted for copper and iron (p < 0.05). In the degenerated intervertebral discs, the strongest relationships were noted between the concentrations of zinc and lead (r = 0.67; p < 0.05), zinc and phosphorus (r = 0.74; p < 0.05), and zinc and calcium (r = 0.77; p < 0.05). It has been indicated that, above all, the concentrations of copper and iron depend on the advancement of radiological changes, according to the Pfirrmann scale; however, no influence on the pain intensity, depending on the concentration of the assessed elements, was found.

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Section: Discussioncontrasting

confidence: 61%

Changes in Elements and Relationships among Elements in Intervertebral Disc Degeneration

Staszkiewicz

Bryś²,

Gładysz

et al. 2022

IJERPH

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“…Our research showed that people with degenerative spine disease had a significantly lower concentration of Zn in the blood serum compared to the control group (0.77 ± 0.22 mg/L vs. 0.83 ± 0.13 mg/L). Mahmood obtained similar results and showed that patients with osteoarthritis of the knee had a much lower concentration of Zn in the blood serum compared to healthy people (0.73 ± 0.17 mg/L vs. 2.1 ± 0.54 mg/L) [ 22 ]. Convergent results were also obtained by Grennan et al, who observed a significantly lower concentration of Zn in the blood serum of people with osteoarthritis compared to the control group [ 23 ].…”

Section: Discussionmentioning

confidence: 94%

Relationship between Selected Micronutrient Concentrations, Total Antioxidant Status, Pain Severity, and the Image of 1H MR Spectroscopy in Degenerative Spine Disease: A Case-Control Study

Jakoniuk

Biegaj

Kochanowicz

et al. 2022

JCM

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Osteoarthritis of the spine is a common disease and constitutes a significant problem in highly developed countries. Due to the aging of the population, the number of patients with advanced degenerative changes continues to grow. Trace elements and antioxidant status may play an active role in the pathogenesis of osteoarthritis of the spine. The aim of this study was to assess the relationship between total antioxidant status (TAS), the concentration of selected elements (Zn, Cu, Se, Mn) in the serum, nutritional and environmental factors, the severity of pain, and images of degenerative changes in the spine demonstrated in proton magnetic resonance spectroscopy (1H MRS). The study included 90 patients with degenerative spine disease and 40 healthy people. Serum Zn, Cu, Se, and Mn concentrations were determined by atomic absorption spectrometry. The Cu/Zn molar ratio was calculated. TAS was determined spectrophotometrically using a ready-made Randox kit. The severity of spine pain was assessed using the visual analogue scale VAS. In the 1H MRS study, the fat/water ratio was determined in L1 and L5 vertebral bodies and in the L4/5 intervertebral disc. In patients with osteoarthritis of the spine, there was a reduced concentration of Zn and Cu in the serum (0.77 ± 0.22 mg/L, 1.1 ± 0.35 mg/L) compared to the control group (0.83 ± 0.13 mg/L, 1.25 ± 0.41 mg/L, respectively). In the study group, we also observed a significantly lower Cu concentration in smokers (1.07 ± 0.35 mg/L) compared to non-smokers (1.17 ± 0.34 mg/L). A relationship between the female sex and a decreased concentration of TAS in the serum, both in people with degenerative spine disease and in healthy people, has been demonstrated. In patients with serum TAS levels below the reference values, the fat/water ratio was higher in the L5 spine shaft, while in those with elevated Mn levels, the value was higher in the L4/L5 intervertebral disc, which indicates a greater degree of degeneration in both cases. Patients with normal serum Cu concentration experienced lower pain intensity assessed in the VAS scale. The study showed some abnormalities in serum trace element levels and TAS in patients with osteoarthritis of the spine.

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“…Mahmood et al showed that serum Zn was significantly lower in OA patients compared to the control group [ 11 ]. The role of Zn in the protection of cartilage is to protect against the action of pro-inflammatory cytokines (IL-1β) through the activation of antioxidant genes and participation in the production and conformation of collagen.…”

Section: Discussionmentioning

confidence: 99%

“…Kubaszewski et al noticed increased concentrations of Cu in the degenerated intervertebral disc [ 8 ]. Previous studies have shown a significant increase in the serum Cu concentration and the Cu/Zn correlation in patients with OA of the knee joint and their duration and severity [ 11 ]. The serum Cu/Zn correlation was significantly higher in aging compared to middle-aged adults, and it was significantly increased in elderly patients compared to healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Bone Tissue Trace Element Content in the Different Radiological Stages of Hip Osteoarthritis

Dąbrowski

Zioła-Frankowska

Frankowski

et al. 2021

IJERPH

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Bone metabolism and the trace element content associated with it change at each stage of degenerative disease. The aim of this study was to find out about the role of the analyzed elements in different stages of hip osteoarthritis. Elements associated with oxidative and enzymatic processes were analyzed depending on the changes in the radiological images of the hip joint. Element content analysis was performed by the inductively coupled plasma mass spectrometry analytical technique. The femoral head in severely osteoarthritic hips (KL3–4) compared to mild grade osteoarthritis (KL2) had a greater content of Cu (median 1.04 vs. 0.04), Sr (median 38.71 vs. 29.59), and Zn (median 75.12 vs. 63.21). There were no significant differences in the content of Mo, Cr, and Fe in the femoral head and neck between the groups. The Cu/Fe correlation was negative in the KL2 group (−0.47) and positive in the KL3–4 groups (0.45). Changes in the content and correlation of trace elements in the hip joint explain the changes in metabolism dependent on the severity of degenerative changes.

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Relationship between Serum Levels of Some Trace Elements, Disease Duration and Severity in Patients with Knee Osteoarthritis

Cited by 11 publications

References 18 publications

Changes in Elements and Relationships among Elements in Intervertebral Disc Degeneration

Changes in Elements and Relationships among Elements in Intervertebral Disc Degeneration

Relationship between Selected Micronutrient Concentrations, Total Antioxidant Status, Pain Severity, and the Image of 1H MR Spectroscopy in Degenerative Spine Disease: A Case-Control Study

Comparison of Bone Tissue Trace Element Content in the Different Radiological Stages of Hip Osteoarthritis

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