Relationship between serum lipid concentrations and posttraumatic stress symptoms in the bereaved after the Sewol ferry disaster: A prospective cohort study

Tae, Hyejin; Huh, Hyu Jung; Hwang, Jihyun; Chae, Jeong‐Ho

doi:10.1016/j.psychres.2018.04.058

Cited by 8 publications

(9 citation statements)

References 47 publications

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“…Other studies found dyslipidaemia, i.e., increased cholesterol, triglyceride, and LDL cholesterol levels in PTSD ( 88 , 91 – 93 ). In contrast to our data, some studies have detected lower HDL cholesterol levels in PTSD ( 89 , 90 , 94 ), or similar triglyceride levels in large groups of community-living adults with or without PTSD ( 87 ). Further, cholesterol, LDL cholesterol and triglyceride levels did not differ between participants with PTSD compared to non-PTSD individuals ( 94 ).…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast to our data, some studies have detected lower HDL cholesterol levels in PTSD ( 89 , 90 , 94 ), or similar triglyceride levels in large groups of community-living adults with or without PTSD ( 87 ). Further, cholesterol, LDL cholesterol and triglyceride levels did not differ between participants with PTSD compared to non-PTSD individuals ( 94 ). Dyslipidaemia and increased BMI are risk factors for various cardiovascular diseases and myocardial infarction in all subjects ( 6 ), especially individuals with PTSD ( 4 , 8 , 10 , 13 ).…”

Section: Discussioncontrasting

confidence: 99%

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Genetic Variants of the Brain-Derived Neurotrophic Factor and Metabolic Indices in Veterans With Posttraumatic Stress Disorder

et al. 2018

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Posttraumatic stress disorder (PTSD) is a trauma and stressor related disorder that may develop after exposure to an event that involved the actual or possible threat of death, violence or serious injury. Its molecular underpinning is still not clear. Brain-derived neurotrophic factor (BDNF) modulates neuronal processes such as the response to stress, but also weight control, energy and glucose homeostasis. Plasma BDNF levels and a functional BDNF Val66Met (rs6265) polymorphism were reported to be associated with PTSD, as well as with increased body mass index (BMI) and dyslipidaemia in healthy subjects and patients with cardio-metabolic diseases, but these results are controversial. The other frequently studied BDNF polymorphism, C270T (rs56164415), has been associated with the development of different neuropsychiatric symptoms/disorders. As far as we are aware, there are no data on the association of BDNF Val66Met and C270T polymorphisms with metabolic indices in PTSD. Due to high rates of obesity and dyslipidaemia in PTSD, the aim of this study was to elucidate the association of BDNF Val66Met and C270T polymorphisms with BMI and lipid levels in veterans with PTSD. We hypothesized that BDNF variants contribute to susceptibility to metabolic disturbances in PTSD. The study included 333 Caucasian males with combat related PTSD, diagnosed according to DSM-5 criteria. Genotyping of the BDNF Val66Met and C270T polymorphisms was performed using the real-time PCR method. Results were analyzed using hierarchical multiple linear regression and the Mann–Whitney test, with p-value corrected to 0.005. The results showed that BDNF Val66Met and BDNF C270T polymorphisms were not significantly associated with BMI, total cholesterol, LDL-cholesterol, HDL-cholesterol or triglycerides. Although the BDNF C270T polymorphism was nominally associated only with HDL-cholesterol in veterans with PTSD, this significance disappeared after controlling for the effect of age. Namely, slightly higher plasma HDL values in T allele carriers, compared to CC homozygotes, were associated with differences in age. Our results, controlled for the critical covariates, revealed that BDNF Val66Met and C270T were not significantly associated with metabolic indices in veterans with PTSD and that these genetic variants do not contribute to susceptibility to metabolic disturbances in PTSD.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Genetic Variants of the Brain-Derived Neurotrophic Factor and Metabolic Indices in Veterans With Posttraumatic Stress Disorder

et al. 2018

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“…A study conducted 10 years after the Wenchuan earthquake reported that sleep disturbances still prevailed among the survivors, especially among men, and indicated that depression and PTSD are associated with the risk of sleep disturbances [ 36 ]. In addition, Tae H et al reported that subjects with PTSD symptoms after the Sewol ferry disaster had lower serum HDL-C levels than those without PTSD [ 37 ]. These findings suggest that increasing stress and worsening psychological health conditions due to a disaster may reduce the duration of sleep, which may be a risk factor for dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Association between Dietary Diversity and Sociopsychological Factors and the Onset of Dyslipidemia after the Great East Japan Earthquake: Fukushima Health Management Survey

Hayashi

Ohira

Sato

et al. 2022

IJERPH

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This study aimed to clarify the relationship between the onset of low-density lipoprotein hypercholesterolemia (hyper-LDLemia), high-density lipoprotein hypocholesterolemia (hypo-HDLemia), and hyper-triglyceridemia (hyper-TGemia) and lifestyle/socio-psychological factors among Fukushima evacuation area residents after the Great East Japan Earthquake. Participants included 11,274 non-hyper-LDLemia, 16,581 non-hypo-HDLemia, and 12,653 non-hyper-TGemia cases in the Fiscal Year (FY) 2011. In FY2011, these participants underwent a health checkup and responded to a mental health and lifestyle survey. The onset of each disease was followed through FY2017. The evacuation experience was positively associated with the risk of hyper-LDLemia, hypo-HDLemia, or hyper-TGemia. Conversely, the middle high dietary diversity score was negatively associated with the onset of hyper-TGemia. Moreover, low sleep satisfaction was positively associated with hypo-HDLemia and hyper-TGemia. The “almost never” exercise habit was positively associated with hypo-HDLemia. Current smoking and audible nuclear power plant explosions were positively associated with the risk of hyper-TGemia. Drinking habits exhibited a negative association with the onset of hyper-LDLemia, hypo-HDLemia, and hyper-TGemia. The results of this study indicate the need for continuous improvement in lifestyle, as well as efforts to eliminate the impact of disasters to prevent the onset of dyslipidemia among disaster evacuees.

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“…It has also been found that those with PTSD have an increased risk of cardiovascular disorder related morbidity (3,4) and mortality (5). A considerable body of evidence suggests that patients with PTSD often exhibit dysregulated lipid metabolomic profiles (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Lipid Signatures in Post-traumatic Stress Disorder

et al. 2022

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BackgroundResearch assessing lipid levels in individuals diagnosed with post-traumatic stress disorder (PTSD) has yielded mixed results. This study aimed to employ meta-analytic techniques to characterize the relationship between the levels of lipid profiles and PTSD.MethodsWe performed meta-analyses of studies comparing profiles and levels of lipids between PTSD patients and healthy individuals by searching Embase, Ovid Medline, Scopus, PsycINFO, and Cochrane databases for the studies until March 2021. Meta-analyses were performed using random-effects models with the restricted maximum-likelihood estimator to synthesize the effect size assessed by standardized mean difference (SMD) across studies.FindingsA total of 8,657 abstracts were identified, and 17 studies were included. Levels of total cholesterol (TC) (SMD = 0.57 95% CI, 0.27–0.87, p = 0.003), low-density lipoprotein (LDL) (SMD = 0.48, 95% CI, 0.19–0.76, p = 0.004), and triglyceride (TG) (SMD = 0.46, 95% CI, 0.22–0.70, p = 0.001) were found to be higher, while levels of high-density lipoprotein (HDL) (SMD = –0.47, –0.88 to –0.07, p = 0.026) were found to be lower in PTSD patients compared to healthy controls. Subgroup analysis showed that TG levels were higher in PTSD patients who were on or off of psychotropic medications, both < 40 and ≥ 40 years of age, and having body mass index of < 30 and ≥ 30 compared to healthy controls.InterpretationThis work suggested dysregulation of lipids in PTSD that may serve as biomarker to predict the risk. The study will be useful for physicians considering lipid profiles in PTSD patients to reduce cardiovascular morbidity and mortality.

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Relationship between serum lipid concentrations and posttraumatic stress symptoms in the bereaved after the Sewol ferry disaster: A prospective cohort study

Cited by 8 publications

References 47 publications

Genetic Variants of the Brain-Derived Neurotrophic Factor and Metabolic Indices in Veterans With Posttraumatic Stress Disorder

Genetic Variants of the Brain-Derived Neurotrophic Factor and Metabolic Indices in Veterans With Posttraumatic Stress Disorder

Association between Dietary Diversity and Sociopsychological Factors and the Onset of Dyslipidemia after the Great East Japan Earthquake: Fukushima Health Management Survey

A Systematic Review and Meta-Analysis of Lipid Signatures in Post-traumatic Stress Disorder

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