Relationship between serum progesterone concentrations and cardiovascular disease, diabetes, and mortality in elderly Swedish men and women: An 8-Year prospective study

Nilsson, Sven Erik G.; Fransson, Eleonor I.; Brismar, Kerstin

doi:10.1016/j.genm.2009.09.011

Cited by 25 publications

(22 citation statements)

References 27 publications

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“…The mechanism by which the CYP17A1 gene leads to hypertension is unclear. related to the levels of sex hormones in the body [34]. A clinical study [35] showed that testosterone levels play an important role in the progression of hypertension in elderly men, whereas lower testosterone levels promote hypertension.…”

Section: Discussionmentioning

confidence: 99%

Relationship between CYP17A1 Genetic Polymorphism and Essential Hypertension in a Chinese Population

Dai¹,

Xie²,

Ma³

et al. 2015

aging dis

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ABSTRACT:The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and a Uighur population including 473 people (181 EH patients and 292 controls) were selected. Five single-nucleotide polymorphisms (SNPs) (rs4919686, rs1004467, rs4919687, rs10786712, and rs2486758) were genotyped using real-time PCR (TaqMan). In the Uighur population, for the total and the men, rs4919686, rs4919687 and rs10786712 were found to be associated with EH (rs4919686: P≤0.02, rs4919687: P≤0.002, rs10786712: P≤0.004, respectively). The difference remained statistically significant after the multivariate adjustment (all P<0.05). The overall distributions of the haplotypes established by SNP1-SNP3, SNP1-SNP4, SNP1-SNP3-SNP5 and SNP1-SNP4-SNP5 were significantly different between the EH patients and the control subjects (for the total: P=0.013, P=0.008, P=0.032, P=0.010, for men: P<0.001, P=0.001, P=0.010, P=0.00). In the Han population, for men, rs2486758 was found to be associated with EH in a recessive model (P=0.007); the significant difference was not retained after the adjustment for the covariates (date not shown). The A allele of rs4919686 could be a susceptible genetic marker, and the T allele of rs10786712 could be a protective genetic marker of EH. The AC genotype of rs4919686, the AG genotype of rs4919687 and the TT genotype of rs10786712 could be protective genetic markers of EH.

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Section: Discussionmentioning

confidence: 99%

Relationship between CYP17A1 Genetic Polymorphism and Essential Hypertension in a Chinese Population

Dai¹,

Xie²,

Ma³

et al. 2015

aging dis

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“…We extracted the estimated RR, adjusted for the highest number of potentially confounding variables, from each of the original articles. If articles presented insufficient data,3 6 9 14–17 authors were requested by email to provide an adjusted estimate of risk resembling the re-expressed effect size. Quality assessment of individual studies was replaced by exploring sources of heterogeneity by meta-regression analyses.…”

Section: Methodsmentioning

confidence: 99%

Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies

Vandenplas

Bacquer

Fiers

et al. 2012

Heart

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14 studies out of 128 electronically identified articles were eligible. Data to be used for meta-analysis could be calculated in seven cases, and in the remaining seven cases, data of three more became available by contacting those authors. Overall, a non-significant association was found with an estimated summary RR of 0.98 for a change of >75th versus <25th percentile in E2 (95% CI 0.74 to 1.31). Mean body mass index (BMI) of the study population (βs -0.8, p<0.004), and quality of E2 assay (βs -0.6, p<0.08) may have modified the relationship between E2 and incident CVD. The present systematic review does not provide evidence for a pronounced harmful or beneficial effect of E2 on risk for incident CVD in healthy men. If present, an effect of E2 on risk for CVD might be modulated by BMI.

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“…The prospective studies of Barrett-Connor & Goodman-Gruen (3) and Nilsson et al (9) did not show an association of endogenous estrogen and androgen levels with CVD mortality. In the recent large study of Sievers et al (32) assessing 2914 women followed for 4.5 years, it was demonstrated that women with the Table 1 Cumulative results of studies investigating associations of endogenous estrogen and androgen levels with cardio-and cerebrovascular disease risk in postmenopausal women (reference in parenthesis).…”

Section: Severity and Mortality Of Cardio-and Cerebro-vascular Diseasementioning

confidence: 96%

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

Παππά

Alevizaki

2012

European Journal of Endocrinology

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Objective: Cardio-and cerebro-vascular diseases are two leading causes of death and long-term disability in postmenopausal women. The acute fall of estrogen in menopause is associated with increased cardiovascular risk. The relative contribution of androgen to this risk is also being recognized. The use of more sensitive assays for estradiol measurement and the study of receptor and carrier protein gene polymorphisms have provided some new information on the clinical relevance of endogenous sex steroids. We provide an update on the role of endogenous sex steroids on cardio-and cerebro-vascular disease in the postmenopausal period. Design and methods: We performed a PubMed search using the terms 'endogenous estrogen', 'androgen', 'cardiovascular disease', 'cerebro-vascular disease', 'stroke', 'carotid artery disease', and 'subclinical atherosclerosis'. Results: The majority of studies show a beneficial effect of endogenous estrogen on the vasculature; however, there are a few studies reporting the contrary. A significant body of literature has reported associations of endogenous estrogen and androgen with early markers of atherosclerosis and metabolic parameters. Data on the relevance of endogenous sex steroids in heart disease and stroke are inconclusive. Conclusions: Most studies support a beneficial role of endogenous estrogens and, probably, an adverse effect of androgens in the vasculature in postmenopausal women. However, the described associations may not always be considered as causal. It is possible that circulating estrogen might represent a marker of general health status or alternatively reflect the sum of endogenous androgens aromatized in the periphery. Elucidating the role of sex steroids in cardio-and cerebro-vascular disease remains an interesting field of future research.

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Relationship between serum progesterone concentrations and cardiovascular disease, diabetes, and mortality in elderly Swedish men and women: An 8-Year prospective study

Cited by 25 publications

References 27 publications

Relationship between CYP17A1 Genetic Polymorphism and Essential Hypertension in a Chinese Population

Relationship between CYP17A1 Genetic Polymorphism and Essential Hypertension in a Chinese Population

Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

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