2018
DOI: 10.1136/annrheumdis-2017-212288
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Relationship between serum urate concentration and clinically evident incident gout: an individual participant data analysis

Abstract: Serum urate level is a strong non-linear concentration-dependent predictor of incident gout. Nonetheless, only about half of those with serum urate concentrations ≥10mg/dL develop clinically evident gout over 15 years, implying a role for prolonged hyperuricaemia and additional factors in the pathogenesis of gout.

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Cited by 159 publications
(106 citation statements)
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“…When combined, variants in these two genes explain 3-4% of variance in urate levels and have strong effects on the risk of gout [4,5]. However, understanding of pathways regulating MSU crystal deposition and the inflammatory response to deposited crystals in gout remains important because fewer than a quarter of people with HU develop gout [6]. Production of the inflammatory cytokine interleukin-1β (IL-1β) is central to the inflammatory response to MSU crystals [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…When combined, variants in these two genes explain 3-4% of variance in urate levels and have strong effects on the risk of gout [4,5]. However, understanding of pathways regulating MSU crystal deposition and the inflammatory response to deposited crystals in gout remains important because fewer than a quarter of people with HU develop gout [6]. Production of the inflammatory cytokine interleukin-1β (IL-1β) is central to the inflammatory response to MSU crystals [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…When combined, variants in these two genes explain 3-4% of variance in urate levels and have strong effects on the risk of gout (4, 5). However, understanding of pathways regulating MSU crystal deposition and the inflammatory response to deposited crystals in gout remains important because fewer than a quarter of people with HU develop gout (6). Production of the inflammatory cytokine interleukin-1β (IL-1β) is central to the inflammatory response to MSU crystals (7, 8).…”
Section: Introductionmentioning
confidence: 99%
“…In other words, even among patients with a serum urate concentration of 10 mg/dL, only about half of them developed clinical symptoms of gout for more than 15 years. This suggests that long-term hyperuricemia and other factors may be involved in the pathogenesis of gout, and we only have a partial understanding of the risk factors of gout [5]. Hyperuricemia is necessary to cause gout, but not enough to cause symptomatic gout.…”
Section: Introductionmentioning
confidence: 99%