Relationship Between Serum Vitamin D Status and Clinical Manifestations of Primary Hyperparathyroidism

Bandeira, Francisco; Caldas, Gustavo; Freese, Eduardo; Griz, Luiz; Faria, Manuel dos Santos; Bandeira, Cristina

doi:10.4158/ep.8.4.266

Cited by 42 publications

(40 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data also demonstrated that the mean of serum 25OHD levels was similar to that found in our postmenopausal patients who had primary asymptomatic hyperparathyroidism (21) and was also no different from the levels reported in the North American patients in the MORE study (4).…”

Section: Discussionsupporting

confidence: 72%

Vitamin D deficiency and its relationship with bone mineral density among postmenopausal women living in the tropics

Bandeira

Griz

Freese

et al. 2010

Arq Bras Endocrinol Metab

Self Cite

View full text Add to dashboard Cite

Objective: To determine vitamin D (25OHD) status and its relationship with bone mineral density (BMD) in 93 postmenopausal women. Subjects and methods: Patients were distributed in two groups: Group 1 -51 to 65 years (n = 45) and Group 2 -66 to 84 years (n = 48); 25OHD and PTH serum were analyzed and a DXA scan of the lumbar spine (LS) and femoral neck (FN) were taken. Results: Mean ± SD of serum 25OHD levels were 80.6 ± 43.3 nmol/L (Group 1) and 63.7 ± 27.6 nmol/L (Group 2); 24% had 25OHD levels < 25 nmol/L and 43.

show abstract

Section: Discussionsupporting

confidence: 72%

Vitamin D deficiency and its relationship with bone mineral density among postmenopausal women living in the tropics

Bandeira

Griz

Freese

et al. 2010

Arq Bras Endocrinol Metab

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our data demonstrated that the mean serum 25-OHD levels were similar to that found in our postmenopausal patients who had primary asymptomatic hyperparathyroidism (30) and were also no different from the levels reported in the North American patients in the MORE study (5).…”

Section: Vitamin D Deficiency In Brazilsupporting

confidence: 70%

Vitamin D deficiency: a global perspective

Bandeira

Griz

Dreyer

et al. 2006

Arq Bras Endocrinol Metab

Self Cite

139

View full text Add to dashboard Cite

Vitamin D is essential for the maintenance of good health. Its sources can be skin production and diet intake. Most humans depend on sunlight exposure (UVB 290-315 nm) to satisfy their requirements for vitamin D. Solar ultraviolet B photons are absorbed by the skin, leading to transformation of 7-dehydrocholesterol into vitamin D3 (cholecalciferol). Season, latitude, time of day, skin pigmentation, aging, sunscreen use, all influence the cutaneous production of vitamin D3. Vitamin D deficiency not only causes rickets among children but also precipitates and exacerbates osteoporosis among adults and causes the painful bone disease osteomalacia. Vitamin D deficiency has been associated with increased risk for other morbidities such as cardiovascular disease, type 1 and type 2 diabetes mellitus and cancer, especially of the colon and prostate. The prevalence of hypovitaminosis D is considerable even in low latitudes and should be taken into account in the evaluation of postmenopausal and male osteoporosis. Although severe vitamin D deficiency leading to rickets or osteomalacia is rare in Brazil, there is accumulating evidence of the frequent occurrence of subclinical vitamin D deficiency, especially in elderly people. RESUMO Deficiência de Vitamina D: Uma Perspectiva Global.A vitamina D é essencial para a manutenção da saúde. A sua fonte principal é a pele ou pode ser ingerida com a dieta. A maioria dos seres humanos depende da exposição solar para adquirir quantidades suficientes de vitamina D. A radiação ultravioleta tipo B transforma o 7-dehidrocolesterol em vitamina D3 (colecalciferol). A época do ano, latitude, pigmentação da pele, idade e uso de filtros solares são fatores que influenciam a produção cutânea. Deficiência de vitamina D pode causar raquitismo e osteomalacia, exacerbar a perda óssea na osteoporose, como também pode associar-se a várias morbidades como doenças cardiovasculares, diabetes mellitus tipo 1 e 2, câncer de prós-tata e de intestino grosso. A prevalência de hipovitaminose D tem sido relatada com grande freqüência mesmo em regiões de baixa latitude e deve ser considerada na avaliação da osteoporose. Embora a deficiência severa levando a osteomalacia possa ser vista raramente no Brasil, evidências se acumulam da freqüente ocorrência de deficiência subclínica, especialmente em idosos.

show abstract

“…All patients were included in this cohort irrespective of symptoms or severity of disease. However, from this cohort, we excluded 43 patients with wrong operation codes and parathyroid implantations (KBBA70), 68 because of lack of spiral CT scans due to various reasons (previous ultrasound investigation or CT scan at referring hospital, refusal, no appearance or administrative errors) and 23 for other reasons: hypercalcaemia caused by chronic renal disease (tertiary hyperparathyroidism) (29), biochemical variables could not be retrieved (29), and errors in entry of central personal registration number (13)). Patients with familial hypocalciuric hypercalcaemia (FHH) were eliminated based on a low calcium/creatinine clearance ratio and evidence of inactivating mutations of the CASR gene (30).…”

Section: Methodsmentioning

confidence: 99%

Renal stones and calcifications in patients with primary hyperparathyroidism: associations with biochemical variables

Starup-Linde

Waldhauer

Rolighed

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To study the prevalence of renal stones and nephrocalcinosis in patients with primary hyperparathyroidism (PHPT) and to appraise biochemical variables as risk factors for developing renal calcifications. Design: Cross-sectional. Materials and methods: All patients (nZ177) undergoing diagnostic evaluation and surgery for PHPT at Aarhus University Hospital between 2007 and 2009. All patients underwent routine spiral CT scans of the abdomen to determine the presence or absence of renal calcifications. Results: A total of 45 patients (25.4%, 95% confidence intervals: 19.0-31.4%) had renal stones (15.3%) and/or renal calcifications (10.2%) on the CT scans. Compared with those without calcification (nZ132), the group with calcification had a significantly lower plasma creatinine level (67.0G25.1 vs 74.6G17.5 mmol/l, 2PZ0.03). Moreover, CaE was higher in PHPT patients with renal calcification than in PHPT patients without (0.91G0.28 vs 0.74G0.40 mmol/mmol, 2PZ0.02). The other measured or derived biochemical variables were similar in the two groups. No biochemical variable was predictive for renal calcifications in a multiple regression analysis. Conclusion: We found a high prevalence of renal calcifications among PHPT patients but no deterioration of renal function. The occurrence of calcifications was related to low plasma creatinine and a high urine calcium/creatinine ratio. However, biochemical markers in general were poor predictors for the risk of renal stones or nephrocalcinosis indicating that routine image diagnostics may be needed for the identification of these complications in order to establish indication for surgery and ensure proper treatment.

show abstract

Relationship Between Serum Vitamin D Status and Clinical Manifestations of Primary Hyperparathyroidism

Cited by 42 publications

References 14 publications

Vitamin D deficiency and its relationship with bone mineral density among postmenopausal women living in the tropics

Vitamin D deficiency and its relationship with bone mineral density among postmenopausal women living in the tropics

Vitamin D deficiency: a global perspective

Renal stones and calcifications in patients with primary hyperparathyroidism: associations with biochemical variables

Contact Info

Product

Resources

About