Relationship between skin acetone and blood β-hydroxybutyrate concentrations in diabetes

Yamane, Norio; Tsuda, Toshitaka; Nose, Kazuo; Yamamoto, Akiko; Ishiguro, Hiroshi; Kondo, Takaharu

doi:10.1016/j.cca.2005.09.016

Cited by 57 publications

(45 citation statements)

References 18 publications

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“…Previously, it has been demonstrated that skin gas acetone is correlated with breath acetone (Naitoh et al 2002). Yamane et al (2006) also reported that skin acetone concentrations of patients with diabetes were significantly higher than those of the control subject. Naito al.…”

Section: Discussionmentioning

confidence: 96%

“…The acetone concentration correlates with the concentration of blood ß-hydroxybutyrate (Reichard et al 1979;Yamane et al 2006). The kinetic responses of ketone bodies to exercise is very complex.…”

Section: Discussionmentioning

confidence: 99%

“…The sampling gas was analyzed with a cold trap gas chromatographic system (Yamane et al 2006;Nose et al 2006). The sample was automatically sucked into the stainless-steel tube from loop cooled with liquid nitrogen.…”

Section: Analytical Procedures and Conditionsmentioning

confidence: 99%

“…The concentration of acetone in expired air and skin gases was measured using modified methods of Yamane et al (2006). Acetone was detected with a flame ionization detector (FID) by a Type GC-14B gas chromatograph (Shimadzu, Kyoto, Japan).…”

Section: Analytical Procedures and Conditionsmentioning

confidence: 99%

“…The relationship between acetone concentration in plasma and breath has been well established (Naioth et al 2002). Yamane et al (2006) reported that skin gas acetone concentrations of patients with diabetes were significantly higher than those of the control subjects. Turner et al (2008) demonstrated that there is a clear relationship between the level of breath acetone and acetone released from the skin.…”

Section: Introductionmentioning

confidence: 98%

See 4 more Smart Citations

Acetone Response with Exercise Intensity

Funada¹,

Tsuda²

2012

Advanced Gas Chromatography - Progress in Agricultural, Biomedical and Industrial Applications

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Analytical Procedures and Conditionsmentioning

confidence: 99%

Section: Analytical Procedures and Conditionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Acetone Response with Exercise Intensity

Funada¹,

Tsuda²

2012

Advanced Gas Chromatography - Progress in Agricultural, Biomedical and Industrial Applications

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Butane‐2,3‐dione: the Key Contributor to Axillary and Foot Odor Associated with an Acidic Note

Hara

Kyuka

Shimizu

2015

Chemistry & Biodiversity

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Human body odor, which contains several volatile organic compounds, possesses various odor qualities. To identify key volatile compounds responsible for the common unpleasant odors derived from human axillae and feet, the odor quality and intensity of 118 human axillae and feet were directly evaluated by sniffing, and odor compounds obtained from the subjects were identified. Furthermore, the sensory differences in odor intensity and quality with and without addition of butane-2,3-dione were evaluated by using the visual analog scale (VAS). An acidic odor was a common unpleasant note in human axillae and feet. Butane-2,3-dione was identified as a key compound associated with this odor. Strong positive correlations between the amount of butane-2,3-dione, and the odor intensities of axillae and feet were observed, and the addition of butane-2,3-dione solution to blended short-chain fatty-acid solutions caused significantly increased VAS values of axillary-like odor, unpleasantness, and odor intensity compared to those of each solution without added butane-2,3-dione.

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Diabetes noninvasive diagnostics and monitoring through volatile biomarkers analysis in the exhaled breath using optical absorption spectroscopy

Kistenev,

Borisov,

Zasedatel

et al. 2023

Journal of Biophotonics

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The review is aimed on the analysis the abilities of noninvasive diagnostics and monitoring of diabetes mellitus (DM) and DM‐associated complications through volatile molecular biomarkers detection in the exhaled breath. The specific biochemical reactions in the body of DM patients and their associations with volatile molecular biomarkers in the breath are considered. The applications of optical spectroscopy methods, including UV, IR, and terahertz spectroscopy for DM‐associated volatile molecular biomarkers measurements, are described. The applications of similar technique combined with machine learning methods in DM diagnostics using the profile of DM‐associated volatile molecular biomarkers in exhaled air or “pattern‐recognition” approach are discussed.

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Relationship between skin acetone and blood β-hydroxybutyrate concentrations in diabetes

Cited by 57 publications

References 18 publications

Acetone Response with Exercise Intensity

Acetone Response with Exercise Intensity

Butane‐2,3‐dione: the Key Contributor to Axillary and Foot Odor Associated with an Acidic Note

Diabetes noninvasive diagnostics and monitoring through volatile biomarkers analysis in the exhaled breath using optical absorption spectroscopy

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