Relationship between sleep disorders and gut dysbiosis: what affects what?

Neroni, Bruna; Evangelisti, Melania; Radocchia, Giulia; Nardo, Giovanni Di; Pantanella, Fabrizio; Villa, Maria Pia; Schippa, Serena

doi:10.1016/j.sleep.2021.08.003

Cited by 54 publications

(36 citation statements)

References 68 publications

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“…Systemic inflammation and TMAO together can lead to foam-cell formation and atherosclerosis [2]. In addition, gut bacteria may produce precursors for neurotransmitters which could affect sleep quality [3].…”

Section: Introductionmentioning

confidence: 99%

“…Obstructive sleep apnoea may lead to gut dysbiosis via various mechanisms. First, some of the bacteria are oxygen-sensitive [4], and intermittent hypoxaemia in animal models was related to alterations in the gut microbiome and a consequential increase in circulating bacterial toxins and bile acids [3,5,6]. Second, sleep fragmentation in animals and humans is itself also related to gut dysbiosis [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…First, some of the bacteria are oxygen-sensitive [4], and intermittent hypoxaemia in animal models was related to alterations in the gut microbiome and a consequential increase in circulating bacterial toxins and bile acids [3,5,6]. Second, sleep fragmentation in animals and humans is itself also related to gut dysbiosis [3,5,6]. In addition, OSA is related to high fat and high carbohydrate intake [7] which can alter the composition of the gut microbiome [8] and is associated with a pro-atherosclerotic microbiome profile [2].…”

Section: Introductionmentioning

confidence: 99%

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Gut Microbiome in Patients with Obstructive Sleep Apnoea

et al. 2022

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Background: Obstructive sleep apnoea (OSA) is a risk factor for cardiovascular disease. Alterations in the gut microbiome have been implicated in the development of cardiovascular disease and may potentially link OSA to its cardiovascular consequences. However, only one study to date has investigated gut microbiomes in adult patients with OSA. Methods: 19 patients with OSA and 20 non-OSA controls participated in the study. Following a diagnostic sleep study, blood was collected for metabolic profiling, and the subjects provided a stool sample for microbiome analysis. The gut microbiome was investigated using the 16S ribosomal RNA method. Results: Patients with OSA had a higher relative abundance of the Proteobacteria phylum (p = 0.03), Gammaproteobacteria class (p = 0.01), Lactobacillae family (p = 0.02), Lactobacillus (p = 0.03), and Roseburia genus (p = 0.03), and a lower abundance of the Actinobacteria phylum (p = 0.03). The abundance of Proteobacteria, Gammaproteobacteria, Lactobacillae, and Lactobacillus were related to disease severity and dyslipidaemia (all p < 0.05), whilst the abundance of Proteobacteria and Gammaproteobacteria was also related to hypertension and cardiovascular disease (all p < 0.05). However, following adjustment for relevant confounders only the association between OSA and Actinobacteria remained significant (p = 0.04). Conclusions: Obstructive sleep apnoea is associated with only subtle changes in gut microbiome. Further studies should investigate gut dysbiosis in OSA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gut Microbiome in Patients with Obstructive Sleep Apnoea

et al. 2022

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“…Much like the observation that NCDs are often linked to socioeconomic position—such that NCDs are disproportionally shouldered by the disadvantaged—research has shown that the composition and diversity of gut (and oral) microbes are similarly associated with socioeconomic position in various populations [ 75 , 76 , 77 , 78 , 79 ]. It is also known that functional changes to the microbiome are mediated by many “lifestyle” factors, including stress [ 80 , 81 , 82 ], sleep [ 83 ], exercise [ 84 ], tobacco use [ 85 ], and, of course, short and long-term dietary choices [ 86 , 87 , 88 ].…”

Section: New Perspectives On the Ecology Of Social Disadvantagementioning

confidence: 99%

Earth Dreams: Reimagining ARPA for Health of People, Places and Planet

Logan¹,

Berman

Prescott

2021

IJERPH

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Bold new approaches are urgently needed to overcome global health challenges. The proposed Advanced Research Projects Agency for Health (ARPA-H) is intended to provide rapid health breakthroughs. While new technologies for earlier disease detection and more effective treatment are critical, we urge equal attention be given to the wider (physical, emotional, social, political, and economic) environmental ecosystems driving the non-communicable disease (NCD) crisis in the first place. This requires an integrated, cross-sectoral vision that spans the interwoven connections affecting health across the scales of people, places, and planet. This wider “exposome” perspective considers biopsychosocial factors that promote resilience and reduce vulnerabilities of individuals and communities over time—the many variables driving health disparities. Since life course health is strongly determined by early life environments, early interventions should be prioritized as a matter of effectiveness and social justice. Here, we explore the origins of the Advanced Research Project Agency and point to its potential to build integrated solutions, with wisdom and ethical value systems as a compass. Since the planned ARPA-H is anticipated to spawn international collaborations, the imagined concept is of relevance to a broad audience of researchers. With appropriate input, the quest for health equity through personalized, precision medicine while deconstructing unacceptable structural inequities may be accelerated.

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“…[145] A probiotic mix improved sleep quality [146] Gut microbiome status including altered metabolism affects sleep [147] Probiotic supplementation improved sleep among postoperative cancer patients. [148] Sleep quality improved with a probiotic complex [149] Specific gut microbiota predicts short vs. normal sleep [150] Gut microbiome dysbiosis can produce an overactive bladder which disrupts sleep [151] A review of gut microbiome status including altered metabolism and the impact on sleep [152] A review of sleep disorders and gut dysbiosis and how they go together [153] A review of sleep disruption and microbiome metabolic dysregulation [154] A review of using microbiota to control the sleep-wake cycle as we age [155]…”

Section: Sleep and Microbiotamentioning

confidence: 99%

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan Following Adverse Childhood Experiences

Dietert¹,

Dietert²

2021

Preprint

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Adverse childhood experiences are known to program children for disrupted biological cycles, premature aging, microbiome dysbiosis, immune-inflammatory misregulation, and chronic disease multimorbidity. To date, the microbiome has not been a major focus of deprogramming efforts despite its emerging role in every aspect of ACE-related dysbiosis and dysfunction. This article examines: 1) the utility of incorporating microorganism-based, anti-aging approaches to combat ACE-programmed chronic diseases (also known as noncommunicable diseases and conditions, NCDs) and 2) microbiome regulation of core systems biology cycles that affect NCD comorbid risk. In this review microbiota influence over three key cyclic rhythms (circadian cycles, the sleep cycle, and the lifespan/longevity cycle) as well as tissue inflammation and oxidative stress are discussed as an opportunity to deprogram ACE-driven chronic disorders. Microbiota, particularly those in the gut, have been shown to affect host-microbe interactions regulating the circadian clock, sleep quality, as well as immune function/senescence and regulation of tissue inflammation. The microimmunosome is one of several systems biology targets of gut microbiota regulation. Furthermore, correcting misregulated inflammation and increased oxidative stress is key to protecting telomere length and lifespan/longevity and extending what has become known as the healthspan. This review article concludes that to reverse the tragedy of ACE-programmed NCDs and premature aging, managing the human holobiont microbiome should become a routine part of healthcare and preventative medicine across the life course.

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Relationship between sleep disorders and gut dysbiosis: what affects what?

Cited by 54 publications

References 68 publications

Gut Microbiome in Patients with Obstructive Sleep Apnoea

Gut Microbiome in Patients with Obstructive Sleep Apnoea

Earth Dreams: Reimagining ARPA for Health of People, Places and Planet

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan Following Adverse Childhood Experiences

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