Relationship between Small Airway Function and Health Status, Dyspnea and Disease Control in Asthma

Takeda, Takumi; Oga, Toru; Niimi, Akio; Matsumoto, Hisako; Ito, Isao; Yamaguchi, Masafumi; Matsuoka, Hiroaki; Jinnai, Makiko; Otsuka, Kojiro; Oguma, Tsuyoshi; Nakaji, Hitoshi; Chin, Kazuo; Mishima, Michiaki

doi:10.1159/000242113

Cited by 125 publications

(117 citation statements)

References 95 publications

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“…Finally, it must be noted that, in our study, the increased values of DRrs5 Ϫ Rrs20 observed at day 15 were due to this lowering of Rrs20 and not to an increase of Rrs5, which was stable. This is relevant because an increment of DRs5-Rs20 has been proposed to be indicative of heightened peripheral airway resistance, [23][24][25] and, as our study suggests, this is not always true, because a relevant decrease of central airways resistance could also modify DRrs5 Ϫ Rrs20 in the same direction.…”

Section: Discussionmentioning

confidence: 72%

Values of Impulse Oscillometry in Healthy Mexican Children and Adolescents

et al. 2014

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BACKGROUND:The impulse oscillometry system (IOS) is increasingly used to evaluate lung function, but individual results must be compared with appropriate reference values. We aimed to obtain such reference values in Mexican children and adolescents. METHODS: Healthy subjects were recruited from kindergartens and schools after their parents signed a consent letter. Respiratory system impedances (Zrs), resistances (Rrs), and reactances (Xrs) were measured at 5, 10, 15, and 20 Hz, and the resonant frequency, reactance area, and difference between Rrs5 minus Rrs20 were also calculated. RESULTS: After exclusion of 4 children who were unable to perform an acceptable IOS recording, the final population comprised 283 children (153 females) 2.7-15.4 y of age. As a group, girls tended to have lower Xrs5 and higher Zrs20 and Rrs20 values. In bivariate analyses, all IOS variables had good correlation with age, height, and weight, and a better straightline fitting was obtained through data transformation to the log 10 (age) or reciprocal (height and weight) values. Comparison of regression lines revealed small differences between males and females, especially in Xrs. Multiple linear regression analysis identified height as the most influential variable in the majority of IOS variables, but age also accounted for a moderate-to-large influence in the regression models in many IOS variables. CONCLUSIONS: In this study, we generated reference equations for each IOS variable in healthy children and adolescents. Although these equations were generated in a Mexican population, they are probably also applicable in other Latin American populations with the same ethnic background.

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Section: Discussionmentioning

confidence: 72%

Values of Impulse Oscillometry in Healthy Mexican Children and Adolescents

et al. 2014

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“…Concerning the quality of life in asthmatic patients, a study using IOS found that R20, X5, and dose of ICS, but not FEV1, significantly accounted for the Asthma Quality of Life Questionnaire in multiple regression analyses (40).…”

Section: Asthmamentioning

confidence: 99%

Clinical Application of the Forced Oscillation Technique

Shirai

Kurosawa

2016

Intern. Med.

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The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory system resistance and reactance during tidal breathing. Recently, its clinical application has spread worldwide with the expansion of commercially available broadband frequency FOT devices, including MostGraph and Impulse Oscillometry. An increasing number of reports have supported the usefulness of the FOT in the management of asthma and chronic obstructive pulmonary disease (COPD). However, the FOT is not a surrogate test for spirometry, but should be used complementarily. Furthermore, reference values are not necessarily available and the interpretation of some measured data is controversial. There is a need to update the international statement for not only technical aspects but also the clinical use of the FOT. In this review, we summarize the previously published studies and discuss how to use the FOT in a clinical setting.

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“…59 The authors speculate that this might reflect ongoing improvement in small airway function in these patients. Two studies from Japan note that X RS relates more closely with quality of life measures than FEV 1 in both patients with asthma 60 and COPD. 61 One of the benefits of the FOT is that one can separately measure inspiratory from expiratory parameters.…”

Section: Measurement Of Airway Resistance By the Forced Oscillation Tmentioning

confidence: 99%

What Does Airway Resistance Tell Us About Lung Function?

2012

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SummarySpirometry is considered the primary method to detect the air flow limitation associated with obstructive lung disease. However, air flow limitation is the end-result of many factors that contribute to obstructive lung disease. One of these factors is increased airway resistance. Airway resistance is traditionally measured by relating air flow and driving pressure using body plethysmography, thus deriving airway resistance (R aw ), specific airway resistance (sR aw ), and specific airway conductance (sG aw ). Other methods to measure airway resistance include the forced oscillation technique (FOT), which allows calculation of respiratory system resistance (R RS ) and reactance (X RS ), and the interrupter technique, which allows calculation of interrupter resistance (R int ). An advantage of these other methods is that they may be easier to perform than spirometry, making them particularly suited to patients who cannot perform spirometry, such as young children, patients with neuromuscular disorders, or patients on mechanical ventilation. Since spirometry also requires a deep inhalation, which can alter airway resistance, these alternative methods may provide more sensitive measures of airway resistance. Furthermore, the FOT provides unique information about lung mechanics that is not available from analysis using spirometry, body plethysmography, or the interrupter technique. However, it is unclear whether any of these measures of airway resistance contribute clinically important information to the traditional measures derived from spirometry (FEV 1 , FVC, and FEV 1 /FVC). The purpose of this paper is to review the physiology and methodology of these measures of airway resistance, and then focus on their clinical utility in relation to each other and to spirometry.

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Relationship between Small Airway Function and Health Status, Dyspnea and Disease Control in Asthma

Cited by 125 publications

References 95 publications

Values of Impulse Oscillometry in Healthy Mexican Children and Adolescents

Values of Impulse Oscillometry in Healthy Mexican Children and Adolescents

Clinical Application of the Forced Oscillation Technique

What Does Airway Resistance Tell Us About Lung Function?

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