Relationship Between Smoking and Structural Damage, Autoimmune Antibodies, and Disability in Rheumatoid Arthritis Patients

Sivas, Filiz

doi:10.5606/archrheumatol.2018.6332

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…It has been reported that males are more susceptible to CS than females with respect to RA development [52]. CS can even affect treatment response to disease-modifying anti-rheumatic drugs (DMARDs) [53] and thus can be a risk of future joint destruction [54][55][56].…”

Section: Cigarette Smoking As the Most Robust Environmental Risk Of Ramentioning

confidence: 99%

The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review

Ishikawa

Terao

2020

Cells

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent proliferation of synovial tissues, which eventually leads to cartilage and bone destruction without effective treatments. Anti-citrullinated cyclic peptide/protein antibody (ACPA) and rheumatoid factor (RF) are two main characteristic autoantibodies found in RA patients and are associated with unfavorable disease outcomes. Although etiologies and causes of the disease have not been fully clarified yet, it is likely that interactive contributions of genetic and environmental factors play a main role in RA pathology. Previous works have demonstrated several genetic and environmental factors as risks of RA development and/or autoantibody productions. Among these, cigarette smoking and HLA-DRB1 are the well-established environmental and genetic risks, respectively. In this narrative review, we provide a recent update on genetic contributions to RA and the environmental risks of RA with a special focus on cigarette smoking and its impacts on RA pathology. We also describe gene–environmental interaction in RA pathogenesis with an emphasis on cigarette smoking and HLA-DRB1.

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Section: Cigarette Smoking As the Most Robust Environmental Risk Of Ramentioning

confidence: 99%

The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review

Ishikawa

Terao

2020

Cells

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“…GRB has received research grants from AbbVie, Pfizer, Roche, and UCB, and has received consulting fees or other remuneration (payment) or participated in speakers' bureaus from/for AbbVie, Eli Lilly, Merck Sharp & Dohme, Pfizer, Roche, Sanofi Genzyme, and UCB. 4 Seoul National University College of Medicine, Seoul, South Korea. 5 Sanofi, Bridgewater, NJ, USA.…”

Section: Supplementary Informationmentioning

confidence: 99%

“…Rheumatoid arthritis (RA) affects nearly 20 million people worldwide [1] and is associated with substantial morbidity and disability [2]. The consequences of RA disease progression on patient health may be influenced by multiple genetic and environmental factors [3], and specific subpopulations of patients with RA can be characterized on the basis of differences in demographic variables, clinical features, and biomarkers, some of which have been shown to be associated with disease outcomes and therapeutic responses [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of sarilumab in combination with csDMARDs or as monotherapy in subpopulations of patients with moderately to severely active rheumatoid arthritis in three phase III randomized, controlled studies

et al. 2020

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Background: The interleukin-6 receptor inhibitor sarilumab demonstrated efficacy in combination with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or as monotherapy in patients with moderately to severely active rheumatoid arthritis (RA) with an inadequate response (IR) or intolerant (INT) to methotrexate (MTX) or tumour necrosis factor (TNF)-α inhibitors. This analysis investigated the efficacy and safety of sarilumab in patient subgroups. Methods: Data were included from phase III studies: two placebo-controlled studies of subcutaneous sarilumab 150/200 mg every 2 weeks (q2w) either + MTX in MTX-IR patients (52 weeks) or + csDMARDs in TNF-IR/INT patients (24 weeks), and a monotherapy study of sarilumab 200 mg q2w vs. adalimumab 40 mg q2w in MTX-IR/INT patients (24 weeks). Prespecified and post hoc subgroups included patient demographics, disease characteristics, and prior treatments. Prespecified and post hoc endpoints included clinical, radiographic, and physical function measures, and p values are considered nominal. Safety was assessed during double-blind treatment.

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“…En algunos estudios se ha encontrado que ciertos componentes del humo del cigarro como la nicotina, hidrocarburos y el monóxido de carbono, elevan la reacción inmunológica de las personas con AR 21 . Así mismo, se asocia el tiempo-exposición al tabaco con el riesgo de padecer la enfermedad 22 , así como la existencia de una relación significativa entre el daño articular progresivo y niveles altos de factor reumatoide, con el hábito de fumar por largo tiempo 23 .…”

Section: Introductionunclassified

Perfil del estilo de vida y actividad inflamatoria en personas con artritis reumatoide

2020

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Introducción: La artritis reumatoide es una enfermedad autoinmune, crónica, degenerativa. Su control está relacionado con la medicación y los factores ambientales, especialmente los estilos de vida, que son potencialmente modificables. Objetivo: Determinar el perfil del estilo de vida de las personas con artritis reumatoide y su relación con el grado de actividad de la enfermedad. Metodología: Estudio descriptivo, transversal y correlacional en adultos con artritis reumatoide. Con previo consentimiento informado, se aplicó clinimetría basada en el nivel de actividad de la enfermedad (DAS28) y el Perfil de Estilos de Vida (PEPS-II) de Nola J. Pender. Para el análisis se recurrió a la estadística descriptiva, correlación de Spearman. Se utilizó el paquete estadístico SPSS versión 22. Resultados: Se valoraron 110 personas, el promedio global del estilo de vida se ubica en un perfil saludable, la dimensión actividad física se clasificó como la más afectada (85.5%). No se encontró correlación entre la actividad de la enfermedad y estilo de vida. Discusión: Existen pocos estudios análogos, los resultados primordiales de estos coinciden con los encontrados. Se hace evidente la necesidad de seguir trabajando en los estilos de vida para lograr disminuir la presencia de actividad inflamatoria en las personas con artritis reumatoide. Conclusiones: No existe una correlación entre las dos variables, es decir, a medida que el perfil de estilo de vida es saludable, la actividad inflamatoria de la enfermedad está activa.

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Relationship Between Smoking and Structural Damage, Autoimmune Antibodies, and Disability in Rheumatoid Arthritis Patients

Cited by 8 publications

References 29 publications

The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review

The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review

Efficacy and safety of sarilumab in combination with csDMARDs or as monotherapy in subpopulations of patients with moderately to severely active rheumatoid arthritis in three phase III randomized, controlled studies

Perfil del estilo de vida y actividad inflamatoria en personas con artritis reumatoide

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