Relationship between socio-demographic, clinical factors, and quality of life in adults living with diabetic nephropathy

D’Souza, Melba Sheila; Labrague, Leodoro J.; Karkada, Subrahmanya Nairy; Kamble, Pramod

doi:10.1016/j.cegh.2019.08.019

Cited by 9 publications

(10 citation statements)

References 22 publications

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“…There was a negative association between health related QoL with age, comorbid illness, and medications [ 29 , 30 ]. Low KDQOL scores were observed for the symptoms, effects, burden, work status, and sleep [ 31 ]. Higher physical, mental component summary, and total KDWOL scores were associated with higher education, low comorbidity, low body mass index, and higher GFR, and lower HbA1c [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Low KDQOL scores were observed for the symptoms, effects, burden, work status, and sleep [ 31 ]. Higher physical, mental component summary, and total KDWOL scores were associated with higher education, low comorbidity, low body mass index, and higher GFR, and lower HbA1c [ 31 ]. This study also shows physical and emotional QoL scores in dialysis patients are lower, and they have an overall poor QoL.…”

Section: Discussionmentioning

confidence: 99%

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Kidney Disease-Specific Quality of Life among Patients on Hemodialysis

Salmi

Kamble

Lazarus

et al. 2021

International Journal of Nephrology

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Introduction. Quality of life (QoL) of hemodialysis patients can be examined in two aspects: kidney-specific quality of life and general quality of life. Objective. To determine the QoL among patients undergoing hemodialysis, to assess patients’ QoL on hemodialysis, and to determine the factors associated with QoL among hemodialysis patients in Oman. Method. A cross-sectional study was carried out with 205 patients to measure the QoL across various demographic and clinical variables in Oman. The Arabic version of the KDQOL-SFtool was used to collect data from patients undergoing hemodialysis to give QoL quantitative measures. Results. The physical-QoL was 45.7 (95% CI, 44.3, 47.0), which is less than half that of a healthy human. The emotional-QoL is 53.33 (95% CI, 51.1, 55.5), slightly more than half in a healthy human-QoL. The difference between physical and emotional-QoL scores is −7.66 (95% CI, −10.3, -5.1), showing that physical QoL is significantly less than emotional-QoL. The overall general QoL score was 49.5 (95% CI, 47.8, 51.2), half the QoL score of a healthy human. Younger patients are also more likely to experience emotional problems compared with older patients. Patients with 5–8 mg/l levels of serum creatinine have lower emotional wellbeing. People on low incomes experienced social difficulties, while the maximum burden was found in physical activities and minimum social function. Conclusion. Both physical (45.7) and emotional (53.3) QoL scores in dialysis patients are nearly half those of an average human. Hence, there is a poor QoL among dialysis patients like other studies, and therefore, further improvement of renal rehabilitation in dialysis patients is warranted to improve patients’ QoL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Kidney Disease-Specific Quality of Life among Patients on Hemodialysis

Salmi

Kamble

Lazarus

et al. 2021

International Journal of Nephrology

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“…11,12 Adults with complex comorbidities, higher body mass index have a significantly lower quality of life, physical functioning, role-physical, body pain, role-emotional, emotional wellbeing. 13 Poor adherence and imperfect recollection of prescribed medication have been associated with a higher frequency of hospitalization in elderly patients. 14 Positive self-care behaviours were correlated with higher income, higher education, lower body weight, and higher awareness of self-management.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of nurse-led cardiac rehabilitation on health care behaviours in adults with chronic heart failure: An experimental design

Arjunan

D’Souza

2021

Clinical Epidemiology and Global Health

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Nonadherence and poor health care behaviors contribute to worsening of heart failure symptoms, in many cases leading to increased morbidity and mortality. Aim: To assess the efficacy of nurse-led cardiac rehabilitation on health care behaviours in adults with chronic heart failure. Method. An experimental design was conducted in India from January to December of 2019. A sample size of 200 adults with heart failure from a tertiary cardiac care center was enrolled. Participants were allocated into an intervention group (n = 100) and a control group (n = 100). A nurse-led cardiac rehabilitation program using a virtual educational video and reminder telephone calls was given to the intervention group for six months. A modified heart failure adherence and health care behaviours scale was used. Results: 78% of the adults in the intervention group and 79% of the adults in the control group were males. 43% of the adults in the intervention group and 32% of the adults in the control group had ≥2 years of chronic heart failure. 42.27% of the participants in the intervention group and 35.05% of the adults in the control group indicated that medical follow-ups were essential. 21.65% of the adults in the intervention group and 13.40% of the adults in the control group expressed no difficulty adhering to the sodium restriction in the posttest2. The participants in the intervention group had higher health care behaviours compared to control group, p < 0.001. Conclusion/Implication: Cardiac nurses need to adopt cardiac rehabilitation in continuity of care for improving health care behaviours for adults with chronic heart failure.

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“…Diabetic nephropathy (DN) is the most common microvascular complication of diabetes mellitus and are also the most common etiology of end-stage renal disease [ 1 , 2 ]. Exudation of inflammatory cells and overexpression of proinflammatory cytokines are important pathogeneses of DN.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of Diabetic Nephropathy in Diabetic Mice by Fasudil through Regulation of Macrophage Polarization

Xie

Lei

Ran

et al. 2020

Journal of Diabetes Research

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Inflammation and fibrosis induced by hyperglycemia are considered to play a critical role in the pathogenesis of diabetic nephropathy. As macrophage polarization may determine the severity and progression of inflammation, regulation of macrophage polarization may be an effective method to treat diabetic complications. Fasudil, a potent Rho-kinase inhibitor, reportedly exhibits anti-inflammatory activity. However, whether fasudil reduces hyperglycemia-induced diabetic nephropathy via regulation of macrophage polarization remains unclear. In this study, we investigate the effect of fasudil on diabetic nephropathy in streptozotocin-induced type 1 diabetic mice. Our data showed that fasudil significantly decreased urinary protein and serum creatinine in diabetic mice, whereas it had no effect on the body weight and blood glucose. We also found increased M1-type macrophages and related proinflammatory cytokines, adverse fibrosis in renal tissue of diabetic mice. Interestingly, treatment of diabetic mice with fasudil increased the number of M2-type macrophages and related anti-inflammatory cytokines, which attenuated renal injury in diabetic mice. Taken together, the results of this study suggest that fasudil could slow the progression of diabetic nephropathy. The possible mechanism might be associated with its induction of M2 macrophage polarization and the reduction of M1 macrophage polarization and inflammation.

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Relationship between socio-demographic, clinical factors, and quality of life in adults living with diabetic nephropathy

Cited by 9 publications

References 22 publications

Kidney Disease-Specific Quality of Life among Patients on Hemodialysis

Kidney Disease-Specific Quality of Life among Patients on Hemodialysis

Efficacy of nurse-led cardiac rehabilitation on health care behaviours in adults with chronic heart failure: An experimental design

Attenuation of Diabetic Nephropathy in Diabetic Mice by Fasudil through Regulation of Macrophage Polarization

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