Relationship between spontaneous variations of muscle sympathetic activity and succeeding changes of blood pressure in man

Wallin, B. Gunnar; Nerhed, C

doi:10.1016/0165-1838(82)90002-9

Cited by 102 publications

(14 citation statements)

References 13 publications

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“…LVC and TVC were determined at the time of each MSNA burst, referred to as cardiac cycle 0, and followed for 10 subsequent cardiac cycles. This time frame was chosen based on the original work of Wallin and Nerhed 17 demonstrating the peak increase in BP occurs at ∼5.5 seconds following a burst of MSNA. In addition, work from our group using phentolamine to block alpha adrenergic receptors has demonstrated the sympathetic origin of the responses, and that this window appropriately captures the time course and nadir changes in vascular conductance following spontaneous MSNA bursts.…”

Section: Methodsmentioning

confidence: 99%

“…With this background in mind, in the present study we made direct measures of muscle SNA (MSNA) combined with beat-to-beat arterial blood pressure and femoral artery blood flow to comprehensively investigate potential racial differences in resting sympathetic vascular transduction. There is a growing interest in assessing sympathetic vascular transduction at rest 13–16 and herein, we employed a signal-averaging method previously developed 17 and validated in our laboratory 13–15 to characterize beat-to-beat changes in leg vascular conductance and blood pressure following spontaneous MSNA bursts. We tested the hypothesis that, relative to CA, AA would exhibit greater vasoconstriction and pressor responses following spontaneous bursts of MSNA.…”

Section: Introductionmentioning

confidence: 99%

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Exaggerated Vasoconstriction to Spontaneous Bursts of Muscle Sympathetic Nerve Activity in Healthy Young Black Men

et al. 2018

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Blacks have the highest prevalence of hypertension, putting them at greater risk of cardiovascular disease and death. Previous studies have reported that, relative to whites, healthy black men have augmented pressor responses to sympathoexcitatory stressors. Although important, these studies do not inform about the resting state and the influence of spontaneous changes in resting muscle sympathetic nerve activity (MSNA). Likewise, little is known about the transduction of MSNA into a vascular response at rest on a beat-to-beat basis. Accordingly, we tested the hypothesis that relative to whites, blacks would exhibit greater vasoconstriction and pressor responses following spontaneous bursts of MSNA. Mean arterial pressure, common femoral artery blood flow, and MSNA were continuously recorded during 20 minutes of supine rest in 35 young healthy men (17 blacks and 18 whites). Signal averaging was used to characterize changes in leg vascular conductance, total vascular conductance, and mean arterial pressure following spontaneous MSNA bursts. Blacks demonstrated significantly greater decreases in leg vascular conductance (blacks: -15.0±1.0%; whites: -11.5±1.2%; =0.042) and total vascular conductance (blacks: -8.6±0.9%; whites: -5.1±0.4%;=0.001) following MSNA bursts, which resulted in greater mean arterial pressure increases (blacks: +5.2±0.6 mm Hg; whites: +3.9±0.3 mm Hg; =0.04). These exaggerated responses in blacks compared with whites were present whether MSNA bursts occurred in isolation (singles) or in combination (multiples) and were graded with increases in burst height. Collectively, these findings suggest that healthy young black men exhibit augmented sympathetic vascular transduction at rest and provide novel insight into potential mechanism(s) by which this population may develop hypertension later in life.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exaggerated Vasoconstriction to Spontaneous Bursts of Muscle Sympathetic Nerve Activity in Healthy Young Black Men

et al. 2018

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“…Our group has recently performed a series of studies examining the ability of spontaneously occurring muscle SNA bursts to dynamically control skeletal muscle vascular tone on a beat-by-beat basis under normal resting conditions in healthy young men (Fairfax et al ., 2013). We adapted a spike triggered averaging method first described by Wallin and Nerhed (Wallin & Nerhed, 1982) and characterized beat-by-beat femoral and brachial vascular conductance (duplex Doppler Ultrasound) responses for 15 cardiac cycles following heartbeats associated with and without muscle SNA bursts (microneurography). The findings indicated that individual, spontaneously occurring muscle SNA bursts produced transient beat-by-beat decreases in femoral and brachial artery vascular conductance that are eliminated by alpha adrenergic blockade.…”

Section: Role Of Sna and No In Modulating Vascular Resistance And Artmentioning

confidence: 99%

Blood pressure regulation VIII: resistance vessel tone and implications for a pro-atherogenic conduit artery endothelial cell phenotype

et al. 2013

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Dysfunction of the endothelium is proposed as the primary initiator of atherosclerotic peripheral artery disease, which occurs mainly in medium to large-sized conduit arteries of the lower extremities (e.g., iliac, femoral, popliteal arteries). In this review article, we propose the novel concept that conduit artery endothelial cell phenotype is determined, in part, by microvascular tone in skeletal muscle resistance arteries through both changes in arterial blood pressure as well as upstream conduit artery shear stress patterns. First, we summarize the literature supporting the involvement of sympathetic nerve activity (SNA) and nitric oxide (NO) in the modulation of microvascular tone and arterial blood pressure. We then focus on the role of elevated blood pressure and shear stress profiles in modulating conduit artery endothelial cell phenotype. Last, we discuss findings from classic and emerging studies indicating that increased vascular resistance, as it occurs in the context of increased SNA and/or reduced NO bioavailability, is associated with greater oscillatory shear stress (e.g., increased retrograde shear) in upstream conduit arteries. The ideas put forth in this review set the stage for a new paradigm concerning the mechanistic link between increased microvascular tone and development of conduit artery endothelial dysfunction and thus increased risk for peripheral artery disease. Indeed, a vast amount of evidence supports the notion that excessive blood pressure and oscillatory shear stress are potent pro-atherogenic signals to the endothelium.

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“…Pain management is a primary component of medical care (1,2). For pain medication selection, clinicians consider both the analgesic properties of a drug and the side effects that medication has on vital physiological processes, such as autonomic nervous system control of arterial blood pressure (BP) (3,4). BP support (i.e., the avoidance of severe hypotension) is critical in the prehospital (i.e., field) setting because advanced cardiovascular support may not be immediately available (1).…”

Section: Introductionmentioning

confidence: 99%

“…Understanding how low-dose (analgesic) fentanyl affects vital physiological processes, such as autonomic nervous system control of BP (3,4), would improve clinical risk-benefit analyses for its use in conscious humans. However, our knowledge about the independent effects of low-dose fentanyl lowering sympathetic outflow, BP, and respiration is primarily limited to studies in anesthetized animals (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) and anesthetized humans (17)(18)(19)(20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Low-dose fentanyl reduces pain perception, muscle sympathetic nerve activity responses, and blood pressure responses during the cold pressor test

Watso

Huang

Belval

et al. 2022

American Journal of Physiology-Regulatory, Integrative and Comp

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Our knowledge about how low-dose (analgesic) fentanyl affects autonomic cardiovascular regulation is primarily limited to animal experiments. Notably, it is unknown if low-dose fentanyl influences human autonomic cardiovascular responses during painful stimuli in humans. Therefore, we tested the hypothesis that low-dose fentanyl reduces perceived pain and subsequent sympathetic and cardiovascular responses in humans during an experimental noxious stimulus. Twenty-three adults (10F/13M; 27±7 y; 26±3 kg•m-2, mean ± SD) completed this randomized, crossover, placebo-controlled trial during two laboratory visits. During each visit, participants completed a cold pressor test (CPT; hand in ~0.4 °C ice bath for two minutes) before and five minutes after drug/placebo administration (75 μg fentanyl or saline). We compared pain perception (100 mm visual analog scale), muscle sympathetic nerve activity (MSNA; microneurography, 11 paired recordings), and beat-to-beat blood pressure (BP; photoplethysmography) between trials (at both pre- and post-drug/placebo time points) using paired, two-tailed t-tests. Before drug/placebo administration, perceived pain (p=0.8287), Δ MSNA burst frequency (p=0.7587), and Δ mean BP (p=0.8649) during the CPT were not different between trials. After the drug/placebo administration, fentanyl attenuated perceived pain (36 vs. 66 mm, p<0.0001), Δ MSNA burst frequency (9 vs. 17 bursts/minute, p=0.0054), and Δ mean BP (7 vs. 13 mmHg, p=0.0174) during the CPT compared to placebo. Fentanyl-induced reductions in pain perception and Δ mean BP were moderately related (r=0.40, p=0.0641). These data provide valuable information regarding how low-dose fentanyl reduces autonomic cardiovascular responses during an experimental painful stimulus.

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Relationship between spontaneous variations of muscle sympathetic activity and succeeding changes of blood pressure in man

Cited by 102 publications

References 13 publications

Exaggerated Vasoconstriction to Spontaneous Bursts of Muscle Sympathetic Nerve Activity in Healthy Young Black Men

Exaggerated Vasoconstriction to Spontaneous Bursts of Muscle Sympathetic Nerve Activity in Healthy Young Black Men

Blood pressure regulation VIII: resistance vessel tone and implications for a pro-atherogenic conduit artery endothelial cell phenotype

Low-dose fentanyl reduces pain perception, muscle sympathetic nerve activity responses, and blood pressure responses during the cold pressor test

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