Relationship Between Survival Time and Size of Homografts in Rats*

Matter, P; Chambler, K.; Lewis, Camille Kaminski; Tg, Blocker

doi:10.1097/00007890-196301020-00002

Cited by 7 publications

(4 citation statements)

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“…In contrast, in the burned patient the diminished immune response is the reason the graft can survive for a prolonged period. These findings of protracted survival of massive skin grafts in the rat are at variance with the findings of Matter, Chambler, Lewis, and Blocker (1963) in similar animals. They Claimed that prolonged survival could not be obtained with an increase in the size of the donor skin and it was suggested that graft acceptance is associated with histocompatibility rather than with quantity of tissue.…”

Section: Other Experimental Studiessupporting

confidence: 63%

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Experimental Skin Grafts and Transplantation Immunity

Ballantyne¹,

Converse²

1979

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Section: Other Experimental Studiessupporting

confidence: 63%

“…However, there are sharp differences of ooinion concerning the effect of graft size upon the immune system of the host in the rat (Matter et al 1963), dog (Veith et al 1966), and guinea pig (Guthy et al 1974). …”

Section: Discussionmentioning

confidence: 99%

Experimental Skin Grafts and Transplantation Immunity

Ballantyne¹,

Converse²

1979

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“…However, some doubt has been thrown on this general view by the recent demonstration of more effective lymphatic function in the hamster cheek pouch (26). Other possible causes for prolonged allograft survival may be the small quantity of tissues implanted (27) and the repopulation of the vessels of these small grafts by host endothelium. With regard to the former, it was in the fetal grafts that rejection generally occurred in a short period, about 5 wk (Table I).…”

Section: Discussionmentioning

confidence: 99%

Observations on Tissue Grafts Established in Rabbit Ear Chambers

Hobbs

Cliff

1971

The Journal of Experimental Medicine

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Early experiments using in vivo microscopy on mammalian tissues were reviewed by Clark et al. (1). The introduction of the transparent rabbit ear chamber, first described by Sandison (2, 3) has allowed microscopic observations to be made of the structure and function of a thin layer of living tissue in the mammal for periods up to several years (4).A modification of the Sandison-Clark rabbit ear chamber which allowed the mica cover slip to be removed, exposing the surface of the stable vascular membrane and then replaced, was adapted by Williams (4) to study graft tissue fragments implanted on the membrane. He found that autografts of a wide variety of tissues in fragments less than 1 mm diameter became vascularized by the anastomosis of graft vessels to the chamber vessels immediately beneath, and slowly became incorporated into the membrane. These grafts retained their structure and visible function (5). On the other hand, allograft tissues, with the exceptions of choroid plexus, ciliary body, V2 carcinoma, and to some extent adrenal, did not survive (5).Recently Greenblatt and others (6) established renal allografts in the hamster cheek pouch chamber and described the glomerular blood flow occurring during their brief survival. However, only fetal graft tissues could be used successfully and the glomerular blood flow always followed a preferential path in a relatively direct stream from the afferent to the efferent arterioles. Subsequently he has described fetal and neonatal heart grafts functioning in these chambers (7).With the eventual aim of studying the process of allograft rejection in vivo, we implanted tissues into the rabbit ear chamber b y a method adapted by Cliff et al. (8). Tissues successfully grafted include liver, kidney, myometrium, and thyroid. Materials and MethodsAnimal.--Rabbits used as recipients were obtained from a closed colony of half-lop rabbits maintained at the Australian National University. They were hardy animals with durable half-lop ears 16 cm in length, very suitable for transparent chamber insertion. Donor rabbits were either of a similar strain, though unrelated, or of an albino strain. Animals were fed on * Present address:

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“…3) Εις τήν περίπτωσιν δευτερογενούς μεταμοσχεύσεως άλλου ιστού έκ του αύτου δότου επαναλαμβάνεται ταχύτερον ό μηχανισμός απορρί ψεως του μοσχεύματος, παρ' όσον είχε κινηθή προηγουμένως, είς τρόπον ώστε ή δευτερογενής άπόρριψις να επεκτείνεται είς όλους τους ιστούς οί όποιοι δέχονται αίμα δι' αιμοφόρων αγγείων. 4) Ή" δευτερογενής άπάντησις είναι ειδική δια τό ζώον, τό όποιον έχρησιμοποιήθη είς τήν αρχική ν μεταμόσχευσιν ή δια κάθε ίσογενές τοι ούτο και δέν έκδηλοΰται έναντι ιστών μή συγγενών γενετικώς και 5) Πολύ μικρά άλλομοσχεύματα δέρματος επιζούν κατά τι περισσότερον τών ευμεγεθών τοιούτων (Martinez et al 1961, Matter et al 1963.…”

Section: κεφαλαγον α'unclassified

Πρωιμος Ανιχνευσις Κυτταρικων Αντισωματων Εις Μυς Υποβληθεντας Εις Μεταμοσχευσιν Δερματος.

Μανταλενάκη-Ασφή¹

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ΔΙΑ ΤΗΣ ΧΡΗΣΙΜΟΠΟΙΗΣΕΩΣ ΝΕΑΣ ΤΕΧΝΙΚΗΣ ΑΝΟΣΟΠΡΟΣΗΛΩΣΕΩΣ ΑΝΙΧΝΕΥΣΑΜΕΝ ΚΥΤΤΑΡΙΚΑ ΑΝΤΙΣΩΜΑΤΑ ΕΠΙ ΜΥΩΝ CBA, ΟΙ ΟΠΟΙΟΙ ΥΠΕΒΛΗΘΗΣΑΝ ΕΙΣ ΜΕΤΑΜΟΣΧΕΥΣΙΝ ΔΕΡΜΑΤΟΣ ΜΥΩΝ AJAX ΚΑΙ CBA. ΤΑ ΛΕΜΦΟΚΥΤΤΑΡΑ ΤΩΝ ΜΥΩΝ ΕΧΟΥΝ ΤΗΝ ΙΚΑΝΟΤΗΤΑ ΝΑ ΠΡΟΣΚΟΛΛΟΥΝ ΣΥΓΓΕΝΗ Η ΑΛΛΟΓΕΝΗ ΕΡΥΘΡΑ ΠΕΡΙΞ ΑΥΤΩΝ IN VITRO ΚΑΙ ΝΑ ΣΧΗΜΑΤΙΖΟΥΝ ΡΟΔΑΚΑΣ. Η ΩΣ ΑΝΩ ΙΚΑΝΟΤΗΣ ΤΩΝ ΑΥΞΑΝΕΙ ΕΙΣ ΤΗΝ ΠΕΡΙΠΤΩΣΙΝ ΜΕΤΑΜΟΣΧΕΥΣΕΩΣ ΔΕΡΜΑΤΟΣ ΕΧΟΝΤΟΣ ΙΣΧΥΡΑΝ ΑΝΤΙΓΟΝΙΚΗΝ ΔΙΑΦΟΡΑΝ (ΑΛΛΟΓΕΝΟΥΣ) ΜΕΤΑ ΤΟΥ ΔΕΚΤΟΥ. ΕΙΣ CBA ΜΥΣ ΦΕΡΟΝΤΑΣ ΜΕΤΑΜΟΣΧΕΥΘΕΝ ΔΕΡΜΑ ΜΥΟΣ AJAX ΠΑΡΕΤΗΡΗΘΗ ΑΥΞΗΣΙΣ ΤΩΝ ΚΥΤΤΑΡΩΝ ΤΩΝ ΠΑΡΑΓΟΝΤΩΝ ΑΛΛΟΡΡΟΔΑΚΑΣ (AFC) ΜΕΤ'ΕΡΥΘΡΩΝ ΤΗΣ ΑΥΤΗΣ ΟΜΑΔΟΣ ΜΥΩΝ ΩΣ ΤΟΥ ΔΟΤΟΥ (AJAX) ΕΙΣ ΤΟΥΣ ΕΠΙΧΩΡΙΟΥΣ ΤΟΥ ΜΟΣΧΕΥΜΑΤΟΣ ΛΕΜΦΑΔΕΝΑΣ. Η ΑΥΞΗΣΙΣ ΑΥΤΗ ΑΡΧΕΤΑΙ ΤΗΝ 4ΗΝ ΜΕΤΕΓΧΕΙΡΗΤΙΚΗΝ ΗΜΕΡΑΝ, ΣΥΝΕΧΙΖΕΤΑΙ ΠΡΟΟΔΕΥΤΙΚΩΣ ΕΩΣ ΤΗΝ 12ΗΝ ΚΑΙ ΕΝ ΣΥΝΕΧΕΙΑ Ο ΑΡΙΘΜΟΣ ΤΩΝ ΚΥΤΤΑΡΩΝ ΕΠΑΝΕΡΧΕΤΑΙ ΠΛΗΣΙΟΝ ΤΩΝ ΦΥΣΙΟΛΟΓΙΚΩΝ ΤΙΜΩΝ ΤΩΝ ΜΑΡΤΥΡΩΝ ΤΗΝ 19ΗΝ ΗΜΕΡΑΝ. ΕΠΙΣΗΣ ΤΑ ΕΡΥΘΡΑ ΤΗΣ ΑΥΤΗΣ ΟΜΑΔΟΣ ΜΥΩΝ ΩΣ ΤΟΥ ΔΕΚΤΟΥ ΑΝΤΙΔΡΟΥΝ ΜΕΤΑ ΤΩΝ ΛΕΜΦΟΚΥΤΤΑΡΩΝ ΛΕΜΦΑΔΕΝΩΝ ΤΩΝ ΔΕΧΘΕΝΤΩΝ ΑΛΛΟΜΟΣΧΕΥΜΑ ΜΥΩΝ (AJAX - CBA) ΚΑΙ ΣΧΗΜΑΤΙΖΟΥΝ ΣΥΡΡΟΔΑΚΑΣ (SFC). Η ΑΥΞΗΣΙΣ ΤΩΝ ΣΥΡΡΟΔΑΚΩΝ ΕΜΦΑΝΙΖΕΤΑΙ ΠΕΡΙ ΤΗΝ 9ΗΝ ΜΕΤΕΓΧΕΙΡΗΤΙΚΗΝ ΗΜΕΡΑΝ. ΚΑΤΑ ΤΟΝ ΧΡΟΝΟΝ ΑΥΤΟΝ, ΤΟ ΜΟΣΧΕΥΜΑ ΔΕΡΜΑΤΟΣ ΑΠΟΡΡΙΠΤΕΤΑΙ ΚΑΙ ΑΛΛΟΑΝΤΙΣΩΜΑΤΑ ΑΝΙΧΝΕΥΟΝΤΑΙ ΕΙΣ ΤΟΝ ΟΡΟΝ. ΣΥΜΜΟΣΧΕΥΜΑΤΑ ΔΕΡΜΑΤΟΣ ΔΕΝ ΕΠΗΡΕΑΖΟΥΝ ΤΟΝ ΑΡΙΘΜΟΝ ΤΩΝ AFC Η SFC. ΕΠΕΙΔΗ Η ΚΥΤΤΑΡΙΚΗ ΑΠΑΝΤΗΣΙΣΔΙΑ ΤΗΣ ΑΝΩΤΕΡΩ ΤΕΧΝΙΚΗΣ ΑΝΙΧΝΕΥΕΤΑΙ ΗΜΕΡΑΣ ΤΙΝΑΣ ΠΡΟ ΤΗΣ ΑΠΟΡΡΙΨΕΩΣ ΤΟΥ ΜΟΣΧΕΥΜΑΤΟΣ ΔΕΡΜΑΤΟΣ, Η ΠΕΡΙΓΡΑΦΕΙΣΑ ΤΕΧΝΙΚΗ, ΔΥΝΑΤΑΙ ΥΠΟ ΩΡΙΣΜΕΝΑΣ ΠΡΟΥΠΟΘΕΣΕΙΣ, ΕΦΑΡΜΟΖΟΜΕΝΗ ΕΙΣ (ΠΕΡΙΚΟΠΗ ΠΕΡΙΛΗΨΗΣ)

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Relationship Between Survival Time and Size of Homografts in Rats*

Cited by 7 publications

References 0 publications

Experimental Skin Grafts and Transplantation Immunity

Experimental Skin Grafts and Transplantation Immunity

Observations on Tissue Grafts Established in Rabbit Ear Chambers

Πρωιμος Ανιχνευσις Κυτταρικων Αντισωματων Εις Μυς Υποβληθεντας Εις Μεταμοσχευσιν Δερματος.

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