Relationship Between Swelling and Drug Release in a Hydrophilic Matrix

Wan, Lucy S.C.; Heng, Paul Wan Sia; Wong, L. F.

doi:10.3109/03639049309063012

Cited by 100 publications

(66 citation statements)

References 8 publications

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“…At higher polymer loading, the viscosity of the gel matrix increases which resulted in a decrease in the effective diffusion coefficient of the drug [16]. Wan et al have also reported that other factors that may contribute to differences in drug dissolution profile as a function of changes in total polymer concentration include differences in water penetration rate, water absorption capacity and polymer swelling [17]. Incorporation of either ethyl cellulose (F4 and F10) or guar gum (F4) also resulted in controlled drug release.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

Ghosh¹,

Barik²

2010

Trop. J. Pharm Res

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Purpose: The objective of the study was to develop matrix tablets for oral controlled release of aceclofenac using ethyl cellulose, guar gum and various grades of cellulose polymers. Methods: Possible drug-excipient interaction was evaluated by high performance liquid chromatography (HPLC) and Fourier infrared spectroscopy (FTIR). The tablets prepared were assessed for their physicochemical, in vitro drug release at pH1.2, 4.5, 6.8 and 7.5 and stability characteristics. Comparison with a 'once daily' commercial aceclofenac product was made in the in vitro studies. Results: There was no interaction between aceclofenac and the polymers used as excipients. Furthermore, the physicochemical properties of the tablets were satisfactory. The release profile of one of the formulated aceclofenac tablets (F7), which contained hydroxypropyl methyl cellulose (HPMC K4M), was statistically similar (p < 0.05) to that of the commercial aceclofenac brand in all the dissolution media. The formulated products ware stable and showed no changes in physical appearance, drug content, or dissolution pattern after storage at 40 o C /75 %RH for 6 months. Conclusion:The results indicate that it is feasible to achieve a stable 'once daily' sustained release aceclofenac tablet formulation by using HPMC K4M of 4000cps viscosity grade as matrix material.

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Section: In Vitro Drug Releasementioning

confidence: 99%

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

Ghosh¹,

Barik²

2010

Trop. J. Pharm Res

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“…Increase in polymer concentration not only caused increase in the viscosity of the gel but also led to a decrease in the diffusion of drug and, therefore, a reduction in the drug release rate [26]. Other factors at play in relation to polymer content probably include change in water penetration rate, water absorption capacity and polymer swelling [27].…”

Section: Discussionmentioning

confidence: 99%

Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets

Nanjwade¹,

Mhase²,

Manvi³

2011

Trop. J. Pharm Res

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“…The second causes a reduction in the diffusion pathlength and evidence of erosion, which increase the release rate. Interestingly, first-order kinetics is evident at HPMC levels greater than 10% w/w of the tablet (8,24,27,28); only at 5% w/w HPMC was erosion observed (25).…”

Section: Introductionmentioning

confidence: 99%

“…Higher molecular weight results in a more viscous gel and slower drug release from an HPMC matrix tablet (8,24,25). In sustained release dosage forms, it gives pH-independent drug release (5,26) due to its nonionic nature.…”

Section: Introductionmentioning

confidence: 99%

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Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

2010

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Abstract. The objectives were to characterize propranolol hydrochloride-loaded matrix tablets using guar gum, xanthan gum, and hydroxypropylmethylcellulose (HPMC) as rate-retarding polymers. Tablets were prepared by wet granulation using these polymers alone and in combination, and physical properties of the granules and tablets were studied. Drug release was evaluated in simulated gastric and intestinal media. Rugged tablets with appropriate physical properties were obtained. Empirical and semi-empirical models were fit to release data to elucidate release mechanisms. Guar gum alone was unable to control drug release until a 1:3 drug/gum ratio, where the release pattern matched a Higuchi profile. Matrix tablets incorporating HPMC provided near zero-order release over 12 h and erosion was a contributing mechanism. Combinations of HPMC with guar or xanthan gum resulted in a Higuchi release profile, revealing the dominance of the high viscosity gel formed by HPMC. As the single rate-retarding polymer, xanthan gum retarded release over 24 h and the Higuchi model best fit the data. When mixed with guar gum, at 10% or 20% xanthan levels, xanthan gum was unable to control release. However, tablets containing 30% guar gum and 30% xanthan gum behaved as if xanthan gum was the sole rate-retarding gum and drug was released by Fickian diffusion. Release profiles from certain tablets match 12-h literature profiles and the 24-h profile of Inderal ® LA. The results confirm that guar gum, xanthan gum, and HPMC can be used for the successful preparation of sustained release oral propranolol hydrochoride tablets.

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Relationship Between Swelling and Drug Release in a Hydrophilic Matrix

Cited by 100 publications

References 8 publications

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets

Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

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