Relationship between symptom load of gastro‐oesophageal reflux disease and health‐related quality of life, work productivity, resource utilization and concomitant diseases: survey of a US cohort

Wahlqvist, P; Karlsson, Maria; Johnson, David A.; Carlsson, Jonas; Bolge, S.; Wallander, Mari‐Ann

doi:10.1111/j.1365-2036.2008.03671.x

Cited by 96 publications

(91 citation statements)

References 29 publications

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“…For individual patients, the presence or absence of erosions may not be of much relevance in symptom generation, since all participants agreed that the impact of the reflux symptoms on QoL appears as substantial in NERD patients as it is in patients with ERD [12]. …”

Section: Clinical Features Of Nerdmentioning

confidence: 99%

Diagnosis and Management of Non-Erosive Reflux Disease – The Vevey NERD Consensus Group

et al. 2009

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Background/Aims: Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world. Methods: An expert international group using the modified Delphi technique examined the quality of evidence and established levels of agreement relating to different aspects of NERD. Discussion focused on clinical presentation, assessment of clinical outcome, pathobiological mechanisms, and clinical strategies for diagnosis and management. Results: Consensus was reached on 85 specific statements. NERD was defined as a condition with reflux symptoms in the absence of mucosal lesions or breaks detected by conventional endoscopy, and without prior effective acid-suppressive therapy. Evidence supporting this diagnosis included: responsiveness to acid suppression therapy, abnormal reflux monitoring or the identification of specific novel endoscopic and histological findings. Functional heartburn was considered a separate entity not related to acid reflux. Proton pump inhibitors are the definitive therapy for NERD, with efficacy best evaluated by validated quality-of-life instruments. Adjunctive antacids or H₂ receptor antagonists are ineffective, surgery seldom indicated. Conclusions: Little is known of the pathobiology of NERD. Further elucidation of the mechanisms of mucosal and visceral hypersensitivity is required to improve NERD management.

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Section: Clinical Features Of Nerdmentioning

confidence: 99%

Diagnosis and Management of Non-Erosive Reflux Disease – The Vevey NERD Consensus Group

et al. 2009

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“…This study demonstrated that the severity and frequency of symptoms lowered the QoL and productivity of GERD patients (17), and the severity of symptoms was related more to QoL than was the frequency of symptoms (18). Existing studies of QoL focused mostly on classical symptoms, but there have also been studies related to atypical symptoms and the QoL.…”

Section: Discussionmentioning

confidence: 99%

Typical symptoms rather than extraesophageal symptoms affect the quality of life in gastroesophageal reflux disease

Jung

Oh²,

Jie³

et al. 2012

Turk J Gastroenterol

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Girifl ve (81.7 vs. 87.5, p<0.05). Compared to the group with asymptomatic erosive reflux disease and the control group, the quality of life was also lower in the group that manifested both typical symptoms and extraesophageal symptoms (79.9 vs. 84.5, p<0.05). Compared with the control group, the quality of life was lower in the group with typical symptoms than in the group with extraesophageal symptoms (79.6 vs. 87.5, p<0.05). Conclusions: Regardless of whether the esophagitis was erosive or non-erosive, the quality of life was deteriorated to a greater extent in symptomatic gastroesophageal reflux disease patients than in the control group, and the quality of life was even lower among patients who had typical symptoms than among patients with extraesophageal manifestations.

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“…Распро-страненность ГЭРБ в странах Западной Европы и Северной Америки составляет 10-20%, в странах Азии -5%, в России -13,3%, с тенденцией к росту [2]. ГЭРБ отнесена к основным популяционно-зна-чимым заболеваниям, в наибольшей степени ухуд-шающим качество жизни человека: согласно про-веденным исследованиям в США, качество жизни у больных с ГЭРБ снижено до 80% [3]. Примерно у трети больных ГЭРБ выявляется воспаление дис-тального отдела пищевода (рефлюкс-эзофагит).…”

Section: актуальностьunclassified

Modern approach to the treatment of complicated hiatal hernias

Cherkasov¹,

Черкасов²,

Startsev³

et al. 2016

Endosk. khir.

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Relationship between symptom load of gastro‐oesophageal reflux disease and health‐related quality of life, work productivity, resource utilization and concomitant diseases: survey of a US cohort

Abstract: SUMMARY BackgroundAnalysis of the burden of gastro-oesophageal reflux disease (GERD) in relation to the severity and frequency of symptoms is essential to identify individuals and groups in whom targeted management is justified.

Cited by 96 publications

References 29 publications

Diagnosis and Management of Non-Erosive Reflux Disease – The Vevey NERD Consensus Group

Diagnosis and Management of Non-Erosive Reflux Disease – The Vevey NERD Consensus Group

Typical symptoms rather than extraesophageal symptoms affect the quality of life in gastroesophageal reflux disease

Modern approach to the treatment of complicated hiatal hernias

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