Relationship between systemic blood pressure, airway blood flow and plasma exudation in guinea‐pig

Cui, ZH; Arakawa, Hirokazu; Kawikova, Ivana; Skoogh, Bengt-Eric; Lötvall, Jan

doi:10.1046/j.1365-201x.1999.00491.x

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…In the present study, the changes in EB extravasation could have been due to changes in vascular permeability, microvascular pressure, or both. Aortic blood pressure is considered the most important inflow pressure for the tracheobronchial circulation and may provide some information on possible hydrostatic pressure changes in the tracheal microcirculation 23 . In our guinea pig preparation cannulation of the carotid artery to monitor systemic arterial blood pressure was not performed, however, left ventricular systolic pressures were measured.…”

Section: Discussionmentioning

confidence: 99%

“…Aortic blood pressure is considered the most important inflow pressure for the tracheobronchial circulation and may provide some information on possible hydrostatic pressure changes in the tracheal microcirculation. 23 In our guinea pig preparation cannulation of the carotid artery to monitor systemic arterial blood pressure was not performed, however, left ventricular systolic pressures were measured. Systolic blood pressure in all treatment groups was similar to those reported in conscious chronically instrumented guinea pigs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Interleukin‐1β and tumour necrosis factor‐α increase microvascular leakage in the guinea pig trachea

Reynolds¹,

Holmes²,

Scicchitano³

2002

Respirology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interleukin‐1β and tumour necrosis factor‐α increase microvascular leakage in the guinea pig trachea

Reynolds¹,

Holmes²,

Scicchitano³

2002

Respirology

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“…Using a guinea pig model, Lo¨tvall et al (41) studied plasma exudation in the lung following bradykinin inhalation in the presence of phosporamidon (NEP inhibitor) or captopril (ACEi). Bradykinin led to dose-dependent increases in plasma exudation (associated with changes in lung function changes) that were exacerbated by both NEP inhibition and captopril as these agents reduce bradykinin degradation, thus enhancing bronchoconstriction (41,42).…”

Section: What Are the Pathological Effects Of Bradykinin?mentioning

confidence: 99%

New topics in bradykinin research

Maurer

Bäder

Baş

et al. 2011

Allergy

159

129

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The kinins are a family of vasoactive peptides including bradykinin, kallidin and methionyl-lysyl-bradykinin, the latter two compounds being converted very rapidly to bradykinin by aminopeptidases. Bradykinin is a low molecular weight (1060.21 Da; C 50 H 73 N 15 O 11 ) nonapeptide, which is rapidly metabolized by endogenous metalloproteases including angiotensin-converting enzyme (ACE or kininase II), neutral endopeptidase (NEP or neprilysin), carboxypeptidase N (CPN or kininase I) and aminopeptidase P (1). Bradykinin has only a short plasma half-life of 15 s, and circulating levels are usually relatively low (0.2-7.1 pM) (2, 3).Much progress was made in understanding the physiological role of kinins with the development of selective antagonists for endothelial B 1 and B 2 receptors (4) and of C1 esterase inhibitor (C1-INH)-and B 2 -receptor-transgenic mice (5, 6). Bradykinin binds these receptors, exerting potent effects in different pathophysiological states (7) (Fig. 1). For example, bradykinin exerts potent antihypertensive, antithrombogenic, antiproliferative and antifibrogenic effects (8) as summarised in Table 1. Bradykinin also participates in inflammatory processes by activating endothelial cells to promote vasodilation and increased vascular permeability, producing classical symptoms of inflammation such as redness, heat, swelling and pain (1, 9). Specifically, bradykinin contributes to tissue hyper-responsiveness and local inflammation in allergic rhinitis, asthma and anaphylaxis, while bradykinin-dependent angioedema can result from hereditary or acquired C1-INH deficiency or the use of ACE inhibitors (ACEi) to treat hypertension, heart failure, diabetes or scleroderma. AbstractBradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B 1 and B 2 receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target.

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Inverse association of Chlamydia pneumoniae infection with high blood pressure in Japanese adults

Nishimura

2001

American Journal of Hypertension

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To determine whether Chlamydia pneumoniae (C. pneumoniae) infection is associated with hypertension in Japanese adults, we measured serum levels of IgA (a marker of reinfection) and of IgG (a marker of previous infection) antibodies to C. pneumoniae by enzyme-linked immunosorbent assay in 112 adults including normotensive and untreated hypertensive subjects and in 117 hypertensive subjects who had been receiving treatment for more than 3 years. In 112 adults, positivity rate for IgA was lower (P < .01) in hypertensive than in normotensive or borderline hypertensive subjects. Positivity rates for IgA and IgG together, which indicate persistent infection of C. pneumoniae, were lower (P < .01) in hypertensive than in normotensive subjects. IgA levels were inversely correlated with systolic blood pressure (SBP) (r = 0.530, P = .0001) and with diastolic blood pressure (DBP) (r = 0.398, P = .0001). In the 117 hypertensive subjects treated with medication, positivity rate for IgA was lower (P < .01) in subjects with poor control than in those with good control. Positivity rates for IgA and IgG together were lower (P < 0.01) in the poor control group than in the good or fair control groups. IgA levels were correlated inversely with SBP and DBP. In both 112 adults and 117 hypertensive patients, levels of SBP or DBP were inversely associated with positivity rates for IgA and IgG together in multiple logistic regression analysis. The results suggest an inverse relationship between high blood pressure and C. pneumoniae infection in Japanese adults.

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Relationship between systemic blood pressure, airway blood flow and plasma exudation in guinea‐pig

Cited by 5 publications

References 20 publications

Interleukin‐1β and tumour necrosis factor‐α increase microvascular leakage in the guinea pig trachea

Interleukin‐1β and tumour necrosis factor‐α increase microvascular leakage in the guinea pig trachea

New topics in bradykinin research

Inverse association of Chlamydia pneumoniae infection with high blood pressure in Japanese adults

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