Relationship between the ABO blood group and Rhesus factors with COVID-19 susceptibility

Ijaz, Sameer; Cheema, Ali Hamza; Rafiq, Anum; Asghar, Asma; Syed, Abdul Rehman Shah; Ahad, Syed Abdul; Eqbal, Farea; Mumtaz, Hassan

doi:10.1080/17474086.2023.2192476

Cited by 2 publications

(1 citation statement)

References 23 publications

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“… 37 And it may be the presence of natural anti-blood group antibodies, particularly anti-A antibody in the blood. 38 Thus, we speculated that patients with non-O blood group had higher risk of CD and VT compared with O-blood group because of fewer anti-A antibody in the blood of patients with non-O blood group. And this assumption could also explain why AB blood group had the highest risk for CD and VT among ABO blood group in multivariate regression analysis and why B blood group was not associated with CD and VT in multivariate regression analysis.…”

Section: Discussionmentioning

confidence: 99%

Associations Between ABO Blood Groups and Diseases in the Digestive System and Vein

Jiang,

Liu,

Zhang

et al. 2024

IJGM

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Purpose The ABO blood type system is crucial for human blood transfusions. However, the relationships between ABO blood groups and diseases in the digestive system and vein have not been elucidated. We investigated the relationships between ABO blood groups and diseases in the digestive system and vein in this study. Patients and Methods A retrospective study on a Chinese population, including 1432 Crohn’s disease (CD), 416 ulcerative colitis (UC), 1140 stomach cancer (SC), 841 colorectal cancer (CRC), 384 pancreatic cancer (PC), 520 liver cancer (LC), and 563 venous thrombosis (VT) patients, was performed. Furthermore, 896 healthy subjects were enrolled as normal controls (NC) in this study. The demographic characteristics of patients and NC were compared using the unpaired t -test and χ 2 test. Multivariate logistic regression model was used to evaluate the association between ABO blood groups and CD and VT. Results ABO blood groups distributions in UC, SC, CRC, PC, and LC patients did not differ from that of NC, but CD and VT patients had significant difference of ABO blood group distribution from that of NC (p = 0.015 and p = 0.002, respectively). Patients with CD and VT had considerably lower rates of type O blood (p = 0.011 and p = 0.001, respectively) and significantly higher rates of type AB blood (p = 0.013 and p = 0.022, respectively) than those with NC. Multivariate logistic regression analysis showed the association of CD and VT with non-O blood types was still significant with a higher risk than with blood group O after adjusting for age and gender (OR = 1.355, 95% CI = 1.100–1.670, p = 0.004 and OR = 1.465, 95% CI = 1.131–1.903, p = 0.004, respectively). Conclusion ABO blood groups distributions in CD and VT patients significantly differed from that of NC. Non-O blood group could be a new predictor for CD and VT.

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Section: Discussionmentioning

confidence: 99%

Associations Between ABO Blood Groups and Diseases in the Digestive System and Vein

Jiang,

Liu,

Zhang

et al. 2024

IJGM

View full text Add to dashboard Cite

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Relationship between the ABO/Rh Blood Group Factors with Coronavirus Disease 2019 Severity and Mortality among Hospitalized Patients in Algeria: A Single-center Study

Ketfi,

Zouai,

Djagheri

et al. 2024

Journal of Advanced Lung Health

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Introduction: The novel coronavirus causes the deadly disease, severe acute respiratory syndrome (SARS). Therefore, it is necessary to identify prognostic factors for patients hospitalized with SARS-coronavirus-2 infection to identify patients with increased mortality risk. Several studies have shown that polymorphisms within the ABO gene are associated with different traits, including risk factors for coronavirus disease 2019 (COVID-19) mortality. Methods: We conducted a prospective, single-center study at the Pulmonologist Department of Rouiba Hospital, Algiers. The medical records of 498 COVID-19 patients enrolled in this cohort study were hospitalized between March 2020 and March 2022. The patient reported the blood group (grouping card) or was carried out on site. The patients were divided into 10 groups: A+, A−, B+, B−, O+, O−, AB+, AB−, (Rhesus+ABO/Rh blood groups), and Rhesus-groups, according to the distribution of ABO blood group. The different ABO blood group of the 498 patients was analyzed and compared according to their prognosis, death, or transfer to an intensive care unit. Results: Four hundred and ninety-eight patients were evaluated, 213 (42.8%) were male, and the mean age was 55.2 years (standard deviation: 15.3). A total of 473 (94.98%) patients were discharged, and 25 (5.02%) died during hospitalization. The number of patients with ARh negative was significantly higher in the dead patients 30% among 10 patients (P = 0.0002) versus 5.6% for A+, compared to improved individuals and more computed tomography scan lesion extension 40% (P = 0.021) between 50% and 75% vs. 13.2% ± 34.0% (P = 0.034) for the A(+) group, and hypernatremia 141.2 ± 2.7 (P = 0.056) versus 137.4 ± 4.36 for A(+) group. The distribution of ABO blood groups was statistically different between the two groups. The dead patients had the blood groups A(−), (30%), A+ (5.6%), B− (0%), B+ (1.5%), AB− (0%), AB+ (0%), O− (20%), and O+ (4.3%), respectively. Conclusion: The protective nature of all blood groups (AB, B, and O+) was observed in patients presenting with COVID-19 symptoms of varying severities. Blood grouping A and especially A− and O− are marked by a high risk of COVID-19 infection, serious form, and mortality and therefore deserve particular attention in their management.

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Relationship between the ABO blood group and Rhesus factors with COVID-19 susceptibility

Cited by 2 publications

References 23 publications

Associations Between ABO Blood Groups and Diseases in the Digestive System and Vein

Associations Between ABO Blood Groups and Diseases in the Digestive System and Vein

Relationship between the ABO/Rh Blood Group Factors with Coronavirus Disease 2019 Severity and Mortality among Hospitalized Patients in Algeria: A Single-center Study

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