Taking into account social, psychological and physiological factors, the labor impact on the human body with disabilities requires the activation of adaptive mechanisms, which in this category has features related to the specifics of the state of health.The purpose of the work is to identify the features of the dynamics of psychophysiological adaptation in disabled people in the course of work.Materials and methods. Hart rate variability indicators, socio-psychological adaptation and stress sensitivity of 130 disabled people were monitored before and after completing work practice at the Center Labor Rehabilitation and Habilitation.Results. The analysis of data depending on the group, category of disability, gender, age and disabling disease revealed the features of adaptive activity of each group of the study, as well as threshold values of psychoemotional indicators relative to the tension of regulatory systems.