Relationship Between the Consumption of Soy and Its Derivatives During Critical Periods of Development and in Adulthood and Endocrine-Metabolic Disorders

Vieira, Adriana Moura; Brasiel, Poliana Guiomar A.; Ferreira, Maíra Schuchter; Aguiar, Aline Silva de; Luquetti, Sheila Cristina Potente Dutra

doi:10.14740/jem449w

Cited by 3 publications

(4 citation statements)

References 51 publications

(89 reference statements)

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“…This reinforces the idea that foods have different effects when consumed as a nutrient or bioactive component alone, especially during a critical period in life 22 . It is known that exposure to different factors in critical phases of life, such as lactation, can promote metabolic changes in the progeny, programming it for health or disease [12][13][14][15][16][17][18][19] .…”

Section: Discussionmentioning

confidence: 99%

“…According to the Developmental Origins of Health and Disease theory, environmental conditions, nutrition, and/or hormones influence homeostatic regulation in the early stages of life and the development or protection against diseases throughout the stages of life [12][13][14][15] . Several studies have shown that nutrition during lactation can increase [16][17][18][19] or decrease 20,21 the risk of developing diseases in adulthood.…”

Section: Introductionmentioning

confidence: 99%

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Maternal soy protein isolate diet during lactation programs deleterious effects on hepatic lipid metabolism, atherogenic indices, and function of adrenal in adult rat offspring

Ferreira

Luquetti

Brasiel

et al. 2021

J Dev Orig Health Dis

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The benefits of consuming soy and its protein have been reported in many studies. However, its phytoestrogen content raises concerns about consumption during lactation and gestation We therefore examined the effects of soybean or soy protein isolate on the parameters-related cardiovascular pathophysiology in lactating mothers and their offsprings at weaning and adulthood. Lactating rats were divided: casein control (C); soy protein isolate (SPI); and soybean (S). At weaning, half of the litter received commercial ration up to 150 days. The levels of 17-β-estradiol and superoxide dismutase were low in the S mothers. For the SPI mothers, we observed a reduction of thiobarbituric acid reactive substances (TBARS). At weaning, atherogenic indices [1 = total cholesterol (TC)/HDL; 2 = LDL/HDL; 3 = TC-HDL/HDL)] decreased in the S and SPI offsprings compared to the casein control group; TBARS and antioxidant enzymes increased in the S offspring, while reduced/oxidized glutathione ratio increased in the SPI offspring, indicating lower oxidative stress. In adulthood, the SPI offspring showed an increase in liver cholesterol and atherogenic index 1 and 3 (vs. C and S) and 2 (vs. S). In addition, we found a decrease in catecholamines in the adrenal medulla and an increase in caffeine-stimulated secretion, but tyrosine hydroxylase expression remained constant. Maternal consumption of SPI during lactation worsened atherogenic indices of the offsprings in adulthood, which was associated with increased liver cholesterol and decreased catecholamines in the adrenal medulla. Soy consumption had no consistent long-term effects on the evaluated parameters compared to casein consumption. The data suggest that the consumption of SPI during lactation should be done with caution.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal soy protein isolate diet during lactation programs deleterious effects on hepatic lipid metabolism, atherogenic indices, and function of adrenal in adult rat offspring

Ferreira

Luquetti

Brasiel

et al. 2021

J Dev Orig Health Dis

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“…Although the benefits of consuming soya products have been reported in many studies, consuming soya products containing phytoestrogens raises concerns (49) . Studies suggest that they may be associated with endocrine-metabolic dysfunctions in adult life (50) , and maternal consumption of soya protein isolate during lactation worsened the atherogenic indices of the offsprings in adulthood (51) .…”

Section: Limitations Of the Scoping Reviewmentioning

confidence: 99%

The associations of soya intakes with non-communicable diseases: a scoping review of meta-analyses

Yip

Chan

2022

Br J Nutr

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This scoping review aimed to identify published meta-analyses of the associations of dietary soy intakes with cardiovascular, cancer, and diabetes II diseases and the best relative risk estimates. A published novel assessment process combining the well-validated Cochrane Review measures, the AMSTAR 2 checklist, and a published algorithm specifically designed for conducting a scoping review of similar meta-analyses was employed. This scoping review identified and evaluated 28 meta-analysis reports, published between 2000 and 2021, on the associations of soy intakes with cardiovascular, cancer, and diabetes II diseases. It identified 18 significantly negatively associated risk-disease pairs for total soy intakes, four significantly negatively associated risk-disease pairs for unfermented soy intakes, and four significantly negatively associated risk-disease pairs for fermented soy intakes when compared high against low intakes. The largest significant risk decrease found was gastric cancer mortalities with relative risk (RR) 0.49 (95% CI: 0.35, 0.68); followed by colorectal cancer mortalities RR 0.59 (95% CI: 0.41, 0.84); ovarian cancer RR 0.52 (95% CI: 0.42, 0.66); and endocrine-related gynaecological cancer RR 0.61 (95% CI: 0.53, 0.72). The fermented soy intake and gastric cancer risk-disease pair was identified to be significantly positively associated, RR 1.22 (95% CI: 1.02, 1.44) when compared high against low intakes. Four significantly negatively associated risk-disease dose-responses were also identified. Being the products with lower greenhouse gas emission intensities, soy products could be the better dietary alternatives to animal products for reducing cardiovascular, cancer, and diabetes II diseases and helping combat climate change.

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“…Programming at a critical stage of development can lead to changes in tissues and organs, which extend throughout life; it may also present a latency period and manifest only in adult life. More studies are emerging to explain the possible mechanisms related to metabolic programming [11,12].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Programming and Nutrition

Brasiel¹,

Luquetti²

2021

New Insights Into Metabolic Syndrome

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Epidemiological and experimental studies have and continue to offer valuable insight into the Developmental Origins of Health and Disease (DOHaD) hypothesis, which emphasizes the importance of early-life nutritional and environmental changes on the increased risk of metabolic diseases in later life. It is now known that non-communicable chronic diseases that were previously associated with lifestyle and genetics have their origins early in life. It is well established that early life environmental signals, including nutrition, set the stage for long-term health and disease risk—effects that span multiple generations. This relationship began still in the intrauterine period and extends throughout the critical period of development. Many types of nutritional challenges including caloric restriction, macronutrient excess, and micronutrient insufficiencies have been shown to induce early life adaptations that produce long-term dysfunction. Several pathways have been suggested to underpin these associations, including epigenetic reprogramming of germ cells. While the mechanisms still remain to be fully investigated, the relationship of nutrition factors in early life and metabolic diseases are clear. This chapter focuses on the role that the nutrition presents during critical periods of development and its repercussions into adulthood.

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Relationship Between the Consumption of Soy and Its Derivatives During Critical Periods of Development and in Adulthood and Endocrine-Metabolic Disorders

Cited by 3 publications

References 51 publications

Maternal soy protein isolate diet during lactation programs deleterious effects on hepatic lipid metabolism, atherogenic indices, and function of adrenal in adult rat offspring

Maternal soy protein isolate diet during lactation programs deleterious effects on hepatic lipid metabolism, atherogenic indices, and function of adrenal in adult rat offspring

The associations of soya intakes with non-communicable diseases: a scoping review of meta-analyses

Metabolic Programming and Nutrition

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