The "mean QRS electrical axis" has been defined by Ziegler (1951) as the average direction in which the excitatory process spreads throughout the ventricular myocardium. This mean axis or vector in the frontal plane may be calculated from the standard limb leads and used as an index of cardiac abnormality. In biometrics the term "deviation" is usually used to indicate the departure of a measurement from an established normal value. Thus in electrocardiography right or left axis deviation denotes departure of the electrical forces from the normal toward one or other side of the body. Accurate interpretation of such deviation is dependent upon well-established normal standards, and several authorities (Johnston, 1961;Ezra, 1961;Milnor, 1962) Ashman, 1937;Epstein, 1948;Gros, Gordon, and Miller, 1951;Yu, Joos, and Katsampes, 1951;Veasy and Adams, 1952; Sodi-Pallares et al., 1958a), and many have contained relatively few cases in later childhood and adolescence. Ziegler (1951) considered that his own data on the mean QRS axis merely acted as a "satisfactory nucleus for further study and revision."This investigation, which is part of a larger study of electrocardiograms in normal children and adolescents (Walker and Rose, 1961; Walker and Wershing, in preparation) was thus designed to test statistically the hypotheses of previous writers and to present normal standards related to age, sex, and body habitus from an adequate number of subjects between the ages of 6 months and 20 years.
SUBJECTS AND METHODSThe records of 2082 patients who attended the Denver Rheumatic Fever Diagnostic Service during the years 1957 to 1961 were reviewed. Despite the special nature of this clinic, a complete history was taken and a thorough physical examination performed, each patient being examined by two or more experienced piediatric cardiologists on the medical centre faculty. Laboratory studies included urine examination, himatocrit, white blood cell count, differential count, sedimentation rate (Wintrobe), C-reactive protein, and serum mucoprotein tyrosine. A 14-lead electrocardiogram (standard 12 leads plus V3R and V7) was recorded on a standard direct writing Cambridge instrument at 25 mm./sec. paper speed, with a calibration of 1 mV= 10 mm. The majority of the earlier patients had either cardiac fluoroscopy or routine radiograms with barium swallow. More recently, if the history was negative and the murmur typically innocent, this examination was omitted in order to avoid unnecessary radiation. As a result of the evaluation of the 2082 case records, 1199 patients were excluded for one of the following reasons: the history or presence of recent illness (as evidenced by physical findings, raised sedimentation rate, white blood count, or abnormalities in the urine), diagnosis or suspicion of rheumatic fever (past or present), the diagnosis of congenital or acquired organic heart disease or the suspicion of such abnormality. The remaining 883 patients were thus regarded as being normal and were included in this study.