Relationship Between the Envelope and the Infectivity of Herpes Simplex Virus.

Herpes simplex virus type 1 strain KOS carries a defective US9 and a mutated US8A gene

“…Since different results regarding the relevance of pUS9 for axonal transport of HSV-1 have been obtained using strains F (Snyder et al, 2008) and NS (McGraw et al, 2009), we attempted to investigate the role of this protein for HSV-1 strains KOS (Smith, 1964) and 17 (Brown et al 1973). The latter two HSV-1 strains were originally isolated from human labial lesions, and are frequently used as parental wild-type strains for the generation of virus mutants and investigation of viral gene functions (Brown et al, 1973;Schaffer et al, 1973).…”

Physicochemical Characterization of Human Herpesvirus 6 Infectivity

“…The number of virus particles of HHV-6 observed was similar to that of herpes simplex virus (HSV) (Smith, 1964;Watson et al, 1963;Shiraki & Takahashi, 1982), HCMV and Epstein-Barr virus (Yamaguchi, 1969). The virus particle/infectivity ratio of HHV-6 was approximately 103 : 1 and those of VZV, HSV and HCMV were approximately 106:1 (Shiraki & Takahashi, 1982), 10 to 80:1 (Smith, 1964;Watson et al, 1963;Shiraki & Takahashi, 1982) and 160 to 1050:1 , respectively.…”

Variation in Thermostability of Herpes Simplex Virus During Replication in Different Hosts

“…Recently, Keller and his co-workers [5,11] had shown that HSV commonly shared the bound glycoprotein with the cellular membrane and that the specific glycosylation of the membrane proteins in HSV infected cells was influenced by the virus and yet in part determined by the host cell. The envelopment of HSV was considered to be essential for the expression of infectivity [10]. The acquired thermostability of HSV reported in this study was dependent upon host cells and thus may have been due to the virus envelope which incorporated host lymphoblastoid cell membrane components.…”