Relationship between the inflammation/immune indexes and deep venous thrombosis (DVT) incidence rate following tibial plateau fractures

Liu, Dawei; Zhu, Yanbin; Chen, Wei; Li, Junyong; Zhao, Kuo; Zhang, Junzhe; Meng, Hongyu; Zhang, Yingze

doi:10.1186/s13018-020-01765-9

Cited by 31 publications

(36 citation statements)

References 34 publications

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“… 4 In addition, in a study of 1179 patients by Liu and colleagues, a similar viewpoint was confirmed. 12 In the present study, we had the same conclusion, and found both factors are risk factors of DVT after lumbar fusion surgeries, further confirming the conclusion of previous literature. D-dimer, as a degradation product of cross-linked fibrin, work as an indicator of both coagulation- and fibrinolysis activation and an elevated D-dimer level is associated with an increased risk in thrombin formation.…”

Section: Discussionsupporting

confidence: 91%

Analysis of risk factors for lower limb deep vein thrombosis in patients after Lumbar Fusion Surgery

Chen

et al. 2020

Pak J Med Sci

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Objective: To identify the risk factors of deep vein thrombosis (DVT) of lower limb in patients undergoing lumbar fusion surgeries, to provide a better understanding of DVT and take prophylactic measures. Methods: This study was carried out in our hospital between January 2016 and February 2020, patients undergoing lumbar fusion surgeries were included and divided into DVT group and non-DVT group, and the medical data including basic demographics, clinical characteristics, operative data, and routine biochemical parameters were collected and analyzed. Results: In the current study, 390 cases were included, 48 cases were enrolled in DVT group and 342 in non-DVT group. The incidence of DVT was 12.3%. There were significant differences in age, hyperlipemia, hypertension, occupation type, D-dimer level, hospital stay, and postoperative exercises (p<0.05), but no significant differences in gender, smoking status, drinking status, coronary heart disease, diabetes mellitus, fused segments, and operation time (p>0.05) between the two groups. In multivariate analysis, age>50 years, hypertension, D-dimer>500ug/L were independent risk factors, while postoperative exercises were protective factor for DVT. Conclusion: Those patients undergoing lumbar fusion surgeries should take more prophylactic measures including postoperative exercises if they were elderly, or hypertensive, or have high D-dimer level, in order to decrease the incidence of DVT. doi: https://doi.org/10.12669/pjms.37.1.3041 How to cite this:Li Q, Yu Z, Chen X, Zhang W. Analysis of risk factors for lower limb deep vein thrombosis in patients after Lumbar Fusion Surgery. Pak J Med Sci. 2021;37(1):239-243. doi: https://doi.org/10.12669/pjms.37.1.3041 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 91%

Analysis of risk factors for lower limb deep vein thrombosis in patients after Lumbar Fusion Surgery

Chen

et al. 2020

Pak J Med Sci

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“…Several studies have investigated the risk factors for perioperative DVT after tibial fractures, 2 , 5 such as body mass index, pre-existing diabetes, delay to ultrasonography, platelet count, neutrophil count, older age, hyponatremia, and prolonged surgical time 1 – 3 . Surgeons always pay attention to fracture classification and build an association between tibial plateau fracture and DVT, 1 , 2 tibial shaft fracture and DVT, 3 and distal tibial fracture and DVT. 4 However, the end of the fracture line is the actual injury plane, and the effect of the plane on perioperative DVT has not been explored.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of DVT varies across locations. The incidence of perioperative DVT in patients with tibial fractures is 4.7 to 16.3% in the tibial plateau, 1 , 2 13.3% in the shaft, 3 and 1.7% in the distal tibia. 4 The incidence of DVT in the proximal segment was higher than that in the distal segment.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between the Fracture Line Plane and Perioperative Deep Vein Thrombosis in Patients with Tibial Fracture

Cai¹,

Wang²,

Wang³

et al. 2021

Clin Appl Thromb Hemost

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Objective To explore the correlation between the fracture line inferior plane and perioperative deep venous thrombosis (DVT) in patients with tibial fractures. Methods Data was collected from the medical records of 536 consecutive patients with tibial fractures at Xi’an Honghui Hospital. The patients were divided into distal, shaft, and proximal segment groups according to the fracture line inferior plane on radiographs. Multivariate logistic regression models were used to identify the role of the inferior plane of the fracture line in perioperative DVT. Results A total of 431 patients were included in the study and 226 patients had perioperative DVT in the lower extremities, including 11 proximal and 215 distal DVTs. Univariate regression analysis showed a significant correlation between the proximal segment and perioperative DVT; however, no correlation was found in the shaft segment group. Additionally, age, coronary heart disease, associated injuries, and time to operation ≥6 days were risk factors for perioperative DVT. However, fixation with intramedullary nails may be a protective factor for perioperative DVT compared with plates. After adjusting for potential confounding factors, the proximal segment group had an increased incidence of perioperative DVT compared to the distal segment group. Conclusions The proximal segment may be correlated with an increased incidence of perioperative DVT by 7.30-fold in patients with tibial fractures compared to that in the distal segment. In clinical practice, surgeons should be vigilant for DVT formation in these patients.

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“…Acute DVT causes a systemic in ammatory response characterized by elevated in ammatory factors and temporal accumulation of in ammatory cells including white blood cells [43,44]. Dawei Liu et al studied 1179 patients of tibial plateau fractures, and found that platelet and neutrophil count were independently associated with elevated D-dimer levels [45]. Moreover, data from 84 patients with lung cancer showed the accumulation of massive neutrophils in the in ammation sites leads to embolism and thrombosis which resulting poor prognosis [46].…”

Section: Discussionmentioning

confidence: 99%

Determinants of Elevated D-Dimer Levels and Long-Term Outcome in Elderly Patients With End-Stage Heart Failure

Tian

Yang

Weng

et al. 2021

Preprint

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Background Previous studies have shown that heart failure is associated with hemostatic abnormalities and hypercoagulable state. Plasma D-dimer levels reflect both fibrin formation and degradation, and elevated D-dimer levels have been associated with poor prognosis in patients with heart failure. However, little is known about their roles in elderly patients with end-stage HF. In present study, we aimed to explore the clinical significance and determinants of plasma D-dimer in elderly patients with end-stage heart failure. Methods A total of 177 patients with heart failure at Beijing Geriatric Hospital from November 1, 2015 to December 30, 2018 were enrolled. All hospitalized patients were obtained D-dimer levels within the first 24 h following admission after obtaining informed consent. Primary endpoint was all-cause mortality. Results A total of 60 patients had elevated D-dimer levels. Blood urea nitrogen (β = 1.106, 95% CI: 1.029–1.190, p = 0.006), NYHA functional class (β = 2.179, 95% CI: 1.170–4.056, p = 0.014) and white blood cell counts (β = 1.188, 95% CI: 1.040–1.358, p = 0.011) were independent risk factors for elevated D-dimer in elderly patients with end-stage heart failure. Albumin (β = 0.803, 95% CI: 0.728–0.885, P ༜ 0.001) was negative risk factor for elevated D-dimer in elderly patients with end-stage heart failure. Elevated D-dimer level was independently associated with increased risk of long-term all-cause mortality (P = 0.048). Conclusions For elderly patients with end-stage heart failure, D-dimer levels were associated with white blood cell counts, blood urea nitrogen, albumin and NYHA functional class and elevated D-dimer level was independently associated with poor long-term outcome.

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Relationship between the inflammation/immune indexes and deep venous thrombosis (DVT) incidence rate following tibial plateau fractures

Cited by 31 publications

References 34 publications

Analysis of risk factors for lower limb deep vein thrombosis in patients after Lumbar Fusion Surgery

Analysis of risk factors for lower limb deep vein thrombosis in patients after Lumbar Fusion Surgery

Correlation Between the Fracture Line Plane and Perioperative Deep Vein Thrombosis in Patients with Tibial Fracture

Determinants of Elevated D-Dimer Levels and Long-Term Outcome in Elderly Patients With End-Stage Heart Failure

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