Relationship between the lesion location of acute ischemic stroke and early depressive symptoms in Japanese patients

Metoki, Norifumi; Sugawara, Norio; Hagii, Joji; Saito, Shin; Shiroto, Hiroshi; Tomita, Tetsu; Yasujima, Minoru; Okumura, Ken; Yasui‐Furukori, Norio

doi:10.1186/s12991-016-0099-x

Cited by 28 publications

(22 citation statements)

References 35 publications

(32 reference statements)

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“…This finding was in accord with previous studies (Armstrong et al, 2017; Lim et al, 2017). However, there was no significant association between PSD and other clinical characteristics, such as lesion location (Guiraud, et al, 2016; Hama et al, 2007; Metoki et al, 2016), although among some of previous studies the results about lesion location remained controversial.…”

Section: Discussionmentioning

confidence: 97%

The association between mean platelet volume levels and poststroke depression

Qiu

Liu

et al. 2018

Brain and Behavior

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ObjectiveHigh levels of mean platelet volume (MPV) had been found in depression subjects. We sought to examine the relationship between MPV and poststroke depression (PSD).MethodsOne hundred and eighty‐five patients with acute ischemic stroke were enrolled in our study. Peripheral venous blood samples were drawn at admission and MPV levels were measured by the automated hematology analyzer. Patients with a HAMD‐17 score >7 were diagnosed as having PSD.ResultsWe found that 60 patients (32.4%) developed PSD, the MPV levels in PSD patients were significantly higher (9.3 ± 1.8 fl) compared to non‐PSD patients (8.5 ± 1.6 fl). High MPV levels (≥9.1 fl) were independently correlated with PSD (OR 2.762, 95% CI 1.138–6.702, p = 0.025).ConclusionsPatients with higher levels of MPV at admission were correlated with the development of PSD at 1 month after stroke and might be a predictor of its presence.

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Section: Discussionmentioning

confidence: 97%

The association between mean platelet volume levels and poststroke depression

Qiu

Liu

et al. 2018

Brain and Behavior

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“…Laterality was one of the first characteristics of stroke lesions reported to be linked to symptoms of PSD with symptoms of depression observed more frequently in right hemispheric ( 22 , 49 , 54 , 56 ). There are, however, studies with contradictory finding, i.e., an association of left hemispheric lesions with higher prevalence and severity of PSD ( 5 , 11 , 57 ).…”

Section: Lesion Location—visual Analysismentioning

confidence: 99%

Post-Stroke Depression: Impact of Lesion Location and Methodological Limitations—A Topical Review

Nickel

Thomalla

2017

Front. Neurol.

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Post-stroke depression (PSD) affects approximately one-third of all stroke patients. It hinders rehabilitation and is associated with worse functional outcome and increased mortality. Since the identification of PSD is a significant clinical problem, clinicians and researchers have tried to identify predictors that indicate patients at risk of developing PSD. This also includes the research question whether there is an association between PSD and stroke lesion characteristics, e.g., lesion size and lesion location. Early studies addressing this question are largely limited by technical constraints and, thus, focused on simple lesion characteristics such as lesion side or proximity of the lesion to the frontal pole of the brain. More recent studies have addressed the impact of involvement of specific neuronal circuits in the stroke lesion. State-of-the-art methods of lesion symptom mapping to study PSD have only been applied to small patient samples. Overall, results are controversial and no clear pattern of stroke lesions associated with PSD has emerged, though there are findings suggesting that more frontal stroke lesions are associated with higher incidence of PSD. Available studies are hampered by methodological limitations, including drawbacks of lesion analysis methods, small sample size, and the issue of patient selection. These limitations together with differences in approaches to assess PSD and in methods of image analysis limit the comparability of results from different studies. To summarize, as of today no definite association between lesion location and PSD can be ascertained and the understanding of PSD rests incomplete. Further insights are expected from the use of modern lesion inference analysis methods in larger patient samples taking into account standardized assessment of possible confounding parameters, such as stroke treatment and reperfusion status.

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“…According to the criteria outlined above after screening based on their abstracts, we initially excluded 3,758 citations. After we screened their full texts, we found that 31 original reports included categorical data on both depression and gender and were included in the meta-analysis (Folstein, Maiberger, & McHugh, 1977;Andersen, Vestergaard, Ingemann-Nielsen, & Lauritzen, 1995;Herrmann, Bartels, Schumacher, & Wallesch, 1995;Bjerg Bendsen, Bjerg Bendsen, Lauritzen, Vilmar, & Bech, 1997;Kase et al, 1998;Gainotti, Antonucci, Marra, & Paolucci, 2001;Singh et al, 2000;Desmond et al, 2003;Hsieh & Kao, 2005;Nys et al, 2005;Tang et al, 2005;Glodzik-Sobanska et al, 2006;Caeiro, Ferro, Santos, & Figueira, 2006;Brodaty, Withall, Altendorf, & Sachdev, 2007;Fuentes, Ortiz, Sanjose, Frank, & Diez-Tejedor, 2009;Nidhinandana et al, 2010;Nishiyama et al, 2010;Tennen et al, 2011;Shi et al, 2015;Choi-Kwon et al, 2012;Zhang, Pan, Wang, & Zhao, 2013;Rajashekaran, Pai, Thunga, & Unnikrishnan, 2013;Angeleri et al, 1997;Finklestein et al, 1982;Grasso et al, 1994;Ng, Chan, & Straughan, 1995;Sun et al, 2014;Jiang, Lin, & Li, 2014;Saxena & Suman, 2015;Wei et al, 2016;Metoki et al, 2016). The study characteristics and demographics are provided in Table 1.…”

Section: Characteristics For Studies Includedmentioning

confidence: 99%

The association between lesion location, sex and poststroke depression: Meta‐analysis

et al. 2017

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BackgroundPoststroke depression (PSD) is a common form of stroke patients. Whether the risk of PSD is influenced by the stroke lesion location and sex remains a matter of debate. The objective of this study was to examine the association between the risk of PSD and the stroke lesion location and sex by performing a systematic meta‐analysis.MethodsSubgroup analyses were performed according to the time interval after stroke onset to assessment for PSD. A total of 31 reports involving 5,309 subjects (for lesion location analysis) and 5,489 subjects (for sex analysis) suffering from stroke were included in this meta‐analysis.ResultsThe pooled odds ratio (OR) of PSD after a left‐hemisphere stroke, compared with a right‐hemisphere stroke was 1.11 (95% confidence interval [CI] 0.82–1.49) and OR of PSD after a male stroke, compared with a female stroke was 0.68 (95% CI 0.58–0.81). Subacute poststroke subgroup (1–6 months) significantly favored PSD occurring after a left hemisphere stroke (OR = 1.50, 95% CI 1.21–1.87). Furthermore, there was a statistically significant association between PSD and female stroke for studies with acute poststroke group (OR = 0.73, 95% CI 0.62–0.86) and subacute poststroke stroke phase (OR = 0.69, 95% CI 0.56–0.86).ConclusionsThis systematic review suggests that patients with left hemisphere stroke may be more susceptible to PSD during subacute phase of stroke and female stroke may be more susceptible to PSD during acute and subacute phase of stroke.

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Relationship between the lesion location of acute ischemic stroke and early depressive symptoms in Japanese patients

Cited by 28 publications

References 35 publications

The association between mean platelet volume levels and poststroke depression

The association between mean platelet volume levels and poststroke depression

Post-Stroke Depression: Impact of Lesion Location and Methodological Limitations—A Topical Review

The association between lesion location, sex and poststroke depression: Meta‐analysis

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