Relationship Between the Levels of Holotranscobalamin and Vitamin B12 in Children

Bozkaya, İkbal Ok; Yaralı, Neşe; Kızılgün, Murat; Özkan, Seçil; Tunç, Bahattin

doi:10.1007/s12288-017-0789-9

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Folate serum was categorized as normal (≥5.0 ng/ml), possible deficiency (2.5−4.9 ng/ml), and deficiency (<2.5 ng/ml). Vitamin B12 serum was categorized as normal (≥200 pg/ml) and the deficiency (<200 pg/ml) (Bozkaya et al 2017). Furthermore, the subject's STM was classified as "good" if the score was more than the median value and vice versa.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Blood Glucose Level and Short-Term Memory Score among 4th and 5th Grades of Primary School Children in Bogor, Indonesia

Khairiyah¹,

Hardinsyah²,

Dewi³

2022

Jgizipangan

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The study aimed to analyze the correlation between Blood Glucose levels (BG) and Short-Term Memory scores (STM) among primary school children in Bogor, as controlled by Socioeconomic Status (SES), BMI-for-age (BAZ), Hemoglobin (Hb), folate, and vitamin B12 levels. It was a cross-sectional study applied for 915 students of the 4 th -5 th grades from 16 primary schools in the suburban area of the Cijeruk district. Morning blood samples were drawn from venous puncture of the inner arm. The specimens were then transported to laboratories to analyze the BG (hexokinase methods), Hb (non-cyanide Hb), as well as folate, and vitamin B12 using Liquid Chromatography and Mass Spectrometry. The STM was obtained through an object recall test performed by trained psychologists. The actual body weight and height were measured to determine BAZ. The characteristics of subjects and their SES were collected through interviews and structured questionnaires. Mann-Whitney and Chi-square tests were performed to compare differences between variables that were grouped by genders. Correlations between predictors and predicted variables were analyzed using simple logistic regression for the bivariates analysis and a binary logistic regression test for the multivariate analysis. There were significant differences in BAZ, BG, and STM between boys and girls (p<0.05). Most of the subject's BAZ was normal (85.2%). About 50.9% of subjects had normal Hb, 99.8% had folate deficiency, 47.8% had normal vitamin B12 level, and 54.9% had good STM score. There was no significant correlation between BAZ, Hb, folate, and vitamin B12 level with STM (p≥0.05), respectively. There was a significant positive correlation between BG and STM (p<0.05; OR=1.583; 95% CI:1.067−2.348) after being controlled by BAZ, subject's characteristic, and SES. In conclusion, optimum blood glucose level improved the STM in primary school children. Therefore, provision of balanced diet, more especially breakfast, for school children is highly important.

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Section: Discussionmentioning

confidence: 99%

Correlation between Blood Glucose Level and Short-Term Memory Score among 4th and 5th Grades of Primary School Children in Bogor, Indonesia

Khairiyah¹,

Hardinsyah²,

Dewi³

2022

Jgizipangan

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“…Its diagnostic value is promising, 3 but data in children are scarce. [12][13][14] Plasma methylmalonic acid (MMA) and total plasma homocysteine are socalled functional markers, reflecting the amount of intra-cellular Cbl available for the two known Cbl-dependent enzymes in human, i.e., methylmalonyl-CoA mutase and methionine synthase, respectively. Their concentrations increase when insufficient Cbl is available.…”

Section: Introductionmentioning

confidence: 99%

Age dependency of plasma vitamin B12 status markers in Dutch children and adolescents

et al. 2021

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Background Vitamin B12 deficiency in children may be associated with (severe) neurological manifestations, therefore recognition is important. Diagnosing vitamin B12 deficiency in children is challenging. This study aimed to investigate plasma methylmalonic acid, holotranscobalamin, and total cobalamin in children 0–18 years of age and to estimate age-dependent reference intervals. Methods Plasma vitamin B12 markers were measured in collected plasma samples of 170 children 0–18 years visiting a local primary care laboratory. All had within-reference hemoglobin and MCV values. Pediatric plasma vitamin B12 biomarkers were measured and reference values were derived thereof. Results Plasma methylmalonic acid was higher in young children, in particular between 1 and 6 months of age; total cobalamin and holotranscobalamin were highest from 0.5 to 4 years and decreased till 10 years of age. Plasma holotranscobalamin was highly correlated with plasma total cobalamin; their ratio was independent of age. Plasma methylmalonic acid was slightly more related to total cobalamin than to holotranscobalamin. A large proportion of mainly young children would be misclassified when adult references are applied. Conclusions Pediatric reference values for cobalamin markers are necessary to allow for early recognition and monitoring of children suspect of (clinical) cobalamin deficiency. Impact We analyzed three plasma vitamin B12 status markers, i.e., total cobalamin, holotranscobalamin, and methylmalonic acid, in the plasma of 170 children 0–18 years of age and were able to derive reference intervals thereof. Recognition of vitamin B12 deficiency in children is important but challenging as pediatric reference intervals for plasma vitamin B12 status markers, particularly plasma holotranscobalamin, are not well described. We think that our results may help early recognition and monitoring of children suspect of (clinical) vitamin B12 deficiency.

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“…between vitamin B12 deficiency and holoTC, Hcy, and blood MMA in children(6,20,21). Studies were generally conducted with adult age group.…”

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confidence: 99%

Diagnosis of Vitamin B12 Deficiency in Children by Using Methylmalonic Acid, Homocysteine and Holotranscobalamine

KİRKİZ,

ARMAN BİLİR,

AZIK

et al. 2023

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Objective: Vitamin B12 deficiency is a common health issue in children. Though the sensivity of serum vitamin B12 measurement for the diagnosis of vitamin B12 deficiency is low, combined methylmalonic acid, homocysteine and holotranscobalamin have been reported to be more specific biomarkers in early and accurate diagnosis. In this study, we aimed to verify the diagnosis of vitamin B12 deficiency in children by measuring methylmalonic acid, homocysteine, holotranscobalamin and to determine the accuracy of them. Material and Methods: The study included 277 patients aged

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Relationship Between the Levels of Holotranscobalamin and Vitamin B12 in Children

Cited by 3 publications

References 15 publications

Correlation between Blood Glucose Level and Short-Term Memory Score among 4th and 5th Grades of Primary School Children in Bogor, Indonesia

Correlation between Blood Glucose Level and Short-Term Memory Score among 4th and 5th Grades of Primary School Children in Bogor, Indonesia

Age dependency of plasma vitamin B12 status markers in Dutch children and adolescents

Diagnosis of Vitamin B12 Deficiency in Children by Using Methylmalonic Acid, Homocysteine and Holotranscobalamine

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