Relationship between the P&lt;sub&gt;300&lt;/sub&gt; Auditory Event-Related Potential and Automated Psychometric Tests

Wright, Gavin; Scott, Laura; Richardson, Cassandra; Rai, G.S.; Exton‐Smith, A. N.

doi:10.1159/000212942

Cited by 10 publications

(7 citation statements)

References 2 publications

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“…This is a surprising finding since computerised psychometric tests are said to have several advantages over subjective tests and, in particular, they are said to (a) ensure that material is presented in a standardised form to all subjects and (b) more importantly, minimise the experimenter's bias. Our own previous studies have shown that results obtained on the automated tests correlate well with not only the latency values for P300 (Wright et al, 1988) but with the results obtained on the MMSE (Rai and Scott, 1989). It may be argued by some that the lack of detectable and significant decline in function over time noted in the results of P300 and the automated psychometric tests may represent increased variability of results of these tests with time in the elderly.…”

Section: Discussionsupporting

confidence: 72%

“…Patients and normal volunteers were divided into two groups because (a) all these assessments involved cooperation from an individual for a period exceeding one and half hours and (b) some volunteers indicated that they would only like to be assessed once a year. Group I (10 patients with SDAT and 10 normal elderly) were followed up at yearly intervals and assessed using Downloaded by [Central Michigan University] at 03:54 03 January 2015 76 CLJNICAL GERONTOLOGIST the MMSE, Kendrick cognitive tests and two computerised automated tests, as described in our earlier paper (Wright et al, 1988). Group I1 (5 patients with SDAT and 5 normal elderly) were followed up at three monthly intervals and assessed using MMSE and P300 latency.…”

Section: Methodsmentioning

confidence: 99%

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Clinical Comments

DeVries

Gallagher‐Thompson

Lichtenberg

et al. 1993

Clinical Gerontologist

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These can take the form of case studies or brief reports of research. The purpose of all clinical comments is to illustrate something concisely. There must be a clear focus on a central theme. Clinical comments should be under four (double spaced) pages, and minimize tables and references. The title should appear on top. At the end of the text, include name(s) of author(s), highest earned degree(s), and institutional affiliation (or city if in private practice). Please submit four copies with a self-addressed, stamped envelope. TLB Cognitive/Behavioral Therapy and the Angry CaregiverABSTRACT. Caregivers of frail elders frequently report symptoms of psychological distress including depression, grief, burden, anxiety, and bumout. Less frequently acknowledged, but commonly present, are feelings of anger and resentment toward the care-receiver. Differentiating depression or anxiety from caregiver anger is useful to establish appropriate treatment goals and to guide the SUMMARY Hopefully, this article will stimulate all mental health clinicians to approach their clients in a more holistic fashion. Though there are some health care providers who are not receptive to information and suggestions about their ~atients from nonmedical clinicians. manv are rece~tive and -appropriateiy responsive. It is definitely the clin&n'i role to do a comorehensive assessment on all mental health clients and then actively advocate for further medical follow-up as indicated.36 months. Although one accepts that the number of patients studied were small, it, however, still raises doubts about the results of drug studies which have used or continue to use such a measure to detect change over a short period such as three months.

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Section: Discussionsupporting

confidence: 72%

Section: Methodsmentioning

confidence: 99%

Clinical Comments

DeVries

Gallagher‐Thompson

Lichtenberg

et al. 1993

Clinical Gerontologist

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“…Hence, there is a need for combined assessment tools which can improve the early diagnosis of dementia (Rachakonda et al, 2004; Dickerson et al, 2007; Dubois et al, 2007; Burns and Morris, 2008; Albert et al, 2011; Jack Jr. et al, 2011; Sperling et al, 2011). Event Related Potentials (ERPs), particularly the P300 wave, has proved to be sensitive to the early effects of AD (Muir et al, 1988; St Clair et al, 1988; Wright et al, 1988; Polich, 1989; Pokryszko-Dragan et al, 2003; Katada et al, 2004; Polich and Corey-Bloom, 2005; Ally et al, 2006; Bonanni et al, 2010; Lai et al, 2010). Using the classical odd-ball paradigm (Sutton et al, 1965) the characteristics of the P300 wave that have proved most useful in experimental and clinical settings are its amplitude and latency.…”

Section: Introductionmentioning

confidence: 99%

P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia

Parra¹,

Ascencio²,

Urquina³

et al. 2012

Front. Neur.

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Only a small proportion of individuals with Mild Cognitive Impairment (MCI) will convert to dementia. Methods currently available to identify risk for conversion do not combine enough sensitivity and specificity, which is even more problematic in low-educated populations. Current guidelines suggest the use of combined markers for dementia to enhance the prediction accuracy of assessment methods. The present study adhered to this proposal and investigated the sensitivity and specificity of the electrophysiological component P300 and standard neuropsychological tests to assess patients with Alzheimer’s disease (AD) and MCI recruited from a low-income country. The neuropsychological battery comprised tests of memory, attention, language, praxis, and executive functions. The P300 was recorded using a classical visual odd-ball paradigm. Three variables were found to achieve sensitivity and specificity values above 80% (Immediate and Delayed recall of word list – CERAD – and the latency of P300) for both MCI and AD. When they entered the model together (i.e., combined approach) the sensitivity for MCI increased to 96% and the specificity remained high (80%). Our preliminary findings suggest that the combined use of sensitive neuropsychological tasks and the analysis of the P300 may offer a very useful method for the preclinical assessment of AD, particularly in populations with low socioeconomic and educational levels. Our results provide a platform and justification to employ more resources to convert P300 and related parameters into a biological marker for AD.

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“…The p AD patients were also required for the controlled evaluation of surgery‐related effects on cognition. As the main outcome measure, we chose event‐related P300 potentials 9,12 because these brain potentials appear to sensitively reflect clinically important aspects of human information‐processing functions in various conditions (e.g., cognitive development 13,14 intoxications 15,16 pharmacological challenge 17,18 and therapy studies 19 metabolic encephalopathies, 22 multiple cerebral infarcts 23–24 and dementia 25,28 …”

mentioning

confidence: 99%