Relationship between the Parameters of Retinal Circulation Measured by Laser Doppler Velocimetry and a Marker of Early Systemic Atherosclerosis

Nagaoka, Taiji; Ishii, Yoshinao; Takeuchi, Toshiharu; Takahashi, Atsushi; Satô, Eiichi; Yoshida, Akitoshi

doi:10.1167/iovs.04-0906

Cited by 25 publications

(16 citation statements)

References 22 publications

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“…49 Interestingly, a significant and independent association between retinal circulation parameters and carotid IMT, a surrogate marker of atherosclerosis, has been described recently in patients with coronary artery disease. 50 In the present study, increased carotid IMT was associated independently with increased WML. This is consistent with the Cardiovascular Health Study data, which showed that increased carotid IMT was independently associated with increased WML.…”

Section: Discussionsupporting

confidence: 58%

Vascular Structure and Function Is Correlated to Cognitive Performance and White Matter Hyperintensities in Older Hypertensive Patients With Subjective Memory Complaints

Kearney‐Schwartz

Rossignol

Bracard

et al. 2009

Stroke

251

168

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Background and Purpose-Arterial stiffening and thickening and endothelial dysfunction may be associated with cognitive decline or white matter hyperintensities (WMH) independently of blood pressure level. We aimed to investigate, using an integrative approach, the relative contributions of structural and functional vascular factors to the degree of cognitive impairment (primary outcome) and the severity of WMH (secondary outcome) in elderly hypertensive patients with subjective memory complaints, a group prone to dementia. Methods-A prospective, dedicated, cross-sectional population of 198 elderly hypertensive patients (mean age 69.3Ϯ6.2 years) with subjective memory complaints underwent a full set of cognitive function assessments, brain MRI with semiquantification of WMH, carotid ultrasonography, carotid-femoral pulse wave velocity, brachial endothelial function, and plasma von Willebrand Factor measurements. Results-After adjustment for the usual cardiovascular risk factors, increased arterial stiffness (as assessed by pulse wave velocity) was significantly and independently associated with memory impairment in men. The severity of WMH was independently associated with increased carotid intima media thickness and stiffness (as assessed by augmentation index) as well as with increased age and plasma levels of von Willebrand Factor, a biomarker of endothelial dysfunction. Conclusions-Our data suggest that vascular abnormalities, independently of blood pressure levels, may play a role in the setting of subjective memory complaints as well as of WMH in elderly hypertensive patients. Arterial thickness and stiffness as well as endothelial function should be assessed simultaneously and may represent additional targets for the prevention of subjective memory complaints and WMH.

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Section: Discussionsupporting

confidence: 58%

Vascular Structure and Function Is Correlated to Cognitive Performance and White Matter Hyperintensities in Older Hypertensive Patients With Subjective Memory Complaints

Kearney‐Schwartz

Rossignol

Bracard

et al. 2009

Stroke

251

168

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“…Using these two independent retinal circulatory parameters, we can evaluate changes in the WSR in the retinal circulation. 35 Most previous studies 1,2,32 did not report WSR data, which is an index of wall shear stress, 28 because the vessel diameter and blood velocity were not measured simultaneously as a result of methodologic difficulties. Only one study reported decreased WSR in the retinal arterioles in response to systemic hyperoxia.…”

Section: Discussionmentioning

confidence: 99%

Role of Nitric Oxide in Regulation of Retinal Blood Flow in Response to Hyperoxia in Cats

Izumi¹,

Nagaoka²,

Satô³

et al. 2008

Invest. Ophthalmol. Vis. Sci.

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“…Functional hemodynamic indices such as max:min velocity ratio, resistivity index, pulsatility index, and WSR have been investigated previously using the retinal vasculature. 24,39,40 Increased peripheral arterial stiffness (measured in the arm and ankle) has been positively correlated with severity of DR. 41 Resistivity and pulsatility indices were not used in this study because of the extraneous influence of downstream impedance. 42,43 WSR is a measure of shear stress (i.e., shear stress ϭ WSR ⅐ viscosity).…”

Section: Discussionmentioning

confidence: 99%

Retinal Arteriolar Diameter, Blood Velocity, and Blood Flow Response to an Isocapnic Hyperoxic Provocation in Early Sight-Threatening Diabetic Retinopathy

Gilmore

Hudson

Nrusimhadevara

et al. 2007

Invest. Ophthalmol. Vis. Sci.

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Relationship between the Parameters of Retinal Circulation Measured by Laser Doppler Velocimetry and a Marker of Early Systemic Atherosclerosis

Abstract: The present findings from this pilot study suggest that the retinal circulatory parameters measured by LDV may be associated with systemic atherosclerosis. These results support recent studies showing an association between retinal microvascular changes and cardiovascular disease.

Cited by 25 publications

References 22 publications

Vascular Structure and Function Is Correlated to Cognitive Performance and White Matter Hyperintensities in Older Hypertensive Patients With Subjective Memory Complaints

Vascular Structure and Function Is Correlated to Cognitive Performance and White Matter Hyperintensities in Older Hypertensive Patients With Subjective Memory Complaints

Role of Nitric Oxide in Regulation of Retinal Blood Flow in Response to Hyperoxia in Cats

Retinal Arteriolar Diameter, Blood Velocity, and Blood Flow Response to an Isocapnic Hyperoxic Provocation in Early Sight-Threatening Diabetic Retinopathy

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