2009
DOI: 10.1007/s11062-009-9092-1
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Relationship between the Plasma Testosterone Level and Pain Reaction Times in Male Rats

Abstract: Male prepubertal (about 4 weeks old) Wistar rats were used to estimate the pain reaction times using the tail-flick and hot-plate models; the testosterone concentration in the blood plasma was measured in all the animals before the tests. The same sets of animals were kept for the next 4 weeks under standard conditions; the experiment was repeated, and pain reaction times were also evaluated in the 8-week-old rats with blood samples collected to determine the plasma testosterone level. The results showed signi… Show more

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“…Prepubertal male Wistar rats aged about 4 weeks and weighing 70-100 g were used in investigating the analgesic activity considering that a pain-protection influence provided by testosterone in adult rats was found in our earlier study [5]. Adult rats weighing 200-250 g were used for examination of the anti-inflammatory properties of the extract.…”
Section: Methodsmentioning
confidence: 99%
“…Prepubertal male Wistar rats aged about 4 weeks and weighing 70-100 g were used in investigating the analgesic activity considering that a pain-protection influence provided by testosterone in adult rats was found in our earlier study [5]. Adult rats weighing 200-250 g were used for examination of the anti-inflammatory properties of the extract.…”
Section: Methodsmentioning
confidence: 99%