Relationship between the presence of liver metastases with histological grading, depth of invasion and nodal involvement in sporadic adenocarcinoma of the large intestine

Abstract

The history of muscle biopsy dates back to 1860, when Duchenne first performed a biopsy on a patient with symptoms of myopathy (1) . Since then, the basic and clinical science of muscle and muscle disease has gone through three stages of development: the classical period, the modern stage and the molecular era.