Relationship between the red blood cell distribution width (RDW) and erythrocyte values in anemic and non-anemic cats

Silva, Paulo Henrique da; Laposy, Cecília Braga; Giuffrida, Rogério; Chaves, Marina Platzeck; Freitas, Maickon Willian de

doi:10.5433/1679-0359.2015v36n5p3227

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…RDW captures the variation in circulating RBC size and can be affected by a change in the number of large or small RBCs. 1,2 Alterations in RDW are expected in patients with increased immature RBCs in circulation, for example, in patients with regenerative anemias or in patients with inflammatory processes that activate hematopoietic cells in the bone marrow. 1,[3][4][5][6] In people, an increase in RDW has been shown to be a strong predictor of mortality in patients with a variety of diseases, including cardiovascular disease, pancreatitis, and peripheral artery disease.…”

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confidence: 99%

Red cell distribution width is a predictor of all‐cause mortality in hospitalized dogs

Ludwik

Heinrich

Friedenberg

2021

J Vet Emergen Crit Care

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Objective: To determine whether RBC distribution width (RDW) is associated with an increased odds of mortality in hospitalized dogs and cats.Design: Retrospective, single-center study; data collected from 2007 to 2017. Setting: University teaching hospital.Animals: Six thousand six hundred and sixty-one animals (5183 dogs and 1478 cats). Interventions: None.Measurements and Main Results: Medical records were identified from animals presented to the emergency service and admitted to the ICU with a CBC and serum biochemistry performed on admission. Patients were stratified into quintiles based upon presenting RDW, and logistic regression modeling was performed to evaluate the relationship between RDW and in-hospital mortality. Canine patients with a presenting RDW in the upper fourth and fifth quintiles had an increased odds of all-cause inhospital mortality (p < 0.0001). Specifically, dogs in the upper fifth quintile had a 2.1fold greater odds of death compared to dogs in the first quintile, and dogs in the upper fourth quintile had a 1.9-fold greater odds of death compared to dogs in the first quintile. This relationship remained significant after adjusting for age, sex, key laboratory values excluding HCT, medical versus surgical disease, and diagnosis category. This relationship was no longer significant with the inclusion of HCT. No significant association was identified between presenting RDW and in-hospital mortality in cats. Conclusions:Hospitalized dogs with higher RDW on presentation to the emergency service have greater odds of all-cause in-hospital mortality compared to dogs with a lower RDW. A similar association between RDW and mortality was not found in cats.Further studies are warranted to assess the usefulness of this biomarker for specific diseases in dogs and to better understand the mechanisms driving the association between increased RDW and mortality in canine patients.

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Section: Introductionmentioning

confidence: 99%

Red cell distribution width is a predictor of all‐cause mortality in hospitalized dogs

Ludwik

Heinrich

Friedenberg

2021

J Vet Emergen Crit Care

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Co-infection of Trichuris vulpis and Toxocara canis in different aged dogs: Influence on the haematological indices

Saichenko

Antipov

Bakhur³

et al. 2021

Biosys. divers.

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Trichuris vulpis and Toxocara canis are worldwide parasitic nematodes affecting dogs and mammals of the Canine family. Due to the special structure of the shells, the eggs of these geohelminths can maintain their viability in soil, sand, water and the environment for a long time. The study involved young (6–12 months old) and adult (1.5–8.0 years old) dogs affected by co-infection of T. vulpis + T. canis; the control group consisted of dewormed healthy animals of the same age. Parasitological examination of dogs' faeces was performed using a "Counting Chamber for Ovoscopic Researches"; morphological parameters, indicators of nutrient metabolism, mineral metabolism and activity of enzymatic systems were determined in blood and serum. According to the results of parasitological research on the dogs, it was found that young animals are more prone to toxocarosis, and adults – trichurosis. The co-infection of nematodes T. vulpis + T. canis in dogs develops several changes in haematological parameters: a significant decrease in erythrocytes, haemoglobin, MCV, MCH, and haematocrit, leukocytosis with basophils and eosinophilia in young infected animals; and eosinophilia and basophilia (15.9 times) in adults, compared with healthy dogs of the same age. Among the changes in serum biochemical parameters, young infected dogs showed a decrease in the concentration of total protein and albumin content, an increase in the content of "acute phase" proteins (α-1, α-2 and β-globulins), an increase in cholesterol and total bilirubin; in adult infected dogs, a decrease in albumin content, an increase in the content of α-1, α-2, and β-globulins, an increase in the concentration of cholesterol and total bilirubin, a decrease in the concentration of urea in comparison with healthy animals were determined. Also, among the indicators of mineral metabolism, a decrease in the concentration of calcium and magnesium in the serum was found in young infected dogs. Among the changes in the enzyme metabolism in the serum of infected dogs, there was an increase in the activity of all studied enzymes in animals of both research groups: ALT, AST, α-amylase, GGT and ALP. Thus, co-infection with nematodes T. vulpis + T. canis has a complex pathogenic effect on the body of dogs of all ages, which manifested itself in multiple changes in haematological parameters. In the future, the authors’ team plan to develop comprehensive measures to combat nematode infections in different living conditions of dogs, taking into account the results of the current research.

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Relationship between the red blood cell distribution width (RDW) and erythrocyte values in anemic and non-anemic cats

Cited by 2 publications

References 6 publications

Red cell distribution width is a predictor of all‐cause mortality in hospitalized dogs

Red cell distribution width is a predictor of all‐cause mortality in hospitalized dogs

Co-infection of Trichuris vulpis and Toxocara canis in different aged dogs: Influence on the haematological indices

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