Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

Tamba, Sachiko; Nishizawa, Hitoshi; Funahashi, Tohru; Okauchi, Yukiyoshi; Ogawa, Takumi; Noguchi, Midori; Fujita, Köichi; Ryo, Miwa; Kihara, Shinji; Iwahashi, Hiromi; Yamagata, Kazuya; Nakamura, Tadashi; Shimomura, Iichiro; Matsuzawa, Yūji

doi:10.2169/internalmedicine.47.0603

Cited by 92 publications

(51 citation statements)

References 43 publications

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“…The current results are mostly in agreement with those of previous reports; hyperuricemia is closely associated with visceral fat accumulation 12, 13 and various metabolic disorders, such as glucose intolerance, elevated blood pressure, dyslipidemia, and atherosclerotic cardiovascular diseases, which are conceptualized as metabolic syndrome 14–18 . However, smoking fell short of being significantly associated with hyperuricemia, in contrast to the findings in previous reports 19, 20 .…”

Section: Discussionsupporting

confidence: 93%

Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis

Tanaka¹,

Nagoshi²,

Kikuchi³

et al. 2017

Sci Rep

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High serum uric acid (UA) level has been assumed to be a risk factor for left ventricular (LV) dysfunction; however, the precise relationship between these conditions has not been fully examined because many confounding factors are associated with UA level. We herein examined the precise relationship by proposing structural equation models. The study population consisted of 1432 cases with ischemic heart disease who underwent cardiac catheterization. Multiple regression analyses and covariance structure analyses were performed to elucidate the cause-and-effect relationship between UA level and LV ejection fraction (LVEF). A path model exploring the factors contributing to LVEF showed that high UA was a significant cause of reduced LVEF (P = 0.004), independent of other significant factors. The degree of atherosclerosis, as estimated by the number of diseased coronary vessels, was significantly affected by high UA (P = 0.005); and the number of diseased coronary vessels subsequently led to reduced LVEF (P < 0.001). Another path model exploring the factors contributing to UA level showed that LVEF was a significant cause of high UA (P = 0.001), while other risk factors were also independent contributing factors. This study clearly demonstrated that there was a close link between high UA and LV dysfunction, which was represented by possible cause-and-effect relationship.

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Section: Discussionsupporting

confidence: 93%

Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis

Tanaka¹,

Nagoshi²,

Kikuchi³

et al. 2017

Sci Rep

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show abstract

“…This pro-oxidative action may accelerate adipose formation (Lee et al, 2009; Johnson et al, 2011) and contribute to insulin resistance (Furukawa et al, 2004). The study from Tamba et al (2008) reported that increased serum uric acid levels correlated with decreased serum adiponectin levels, which is consistent with this study. Multiple regression analysis confirmed the significant inverse correlation between serum uric acid levels and adiponectin levels.…”

Section: Discussionsupporting

confidence: 91%

Hyperuricemia in Children and Adolescents with Autism Spectrum Disorder Treated with Risperidone: The Risk Factors for Metabolic Adverse Effects

et al. 2017

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Background: Atypical antipsychotics have been found to be associated with hyperuricemia. Risperidone, one of the atypical antipsychotics, might be related to the hyperuricemia among autism spectrum disorder (ASD) patients. The aims of this study were to determine the prevalence of hyperuricemia in ASD patients treated with risperidone and to determine associations between serum uric acid levels and risperidone dosage, treatment duration, and metabolic parameters.Methods: 127 children and adolescents with ASD treated with risperidone and 76 age-matched risperidone-naïve patients with ASD were recruited. The clinical data and laboratory data were analyzed. Hyperuricemia was defined as serum uric acid >5.5 mg/dl.Results: Hyperuricemia was present in 44.70% of risperidone-naïve patients with ASD and 57.50% of ASD patients treated with risperidone. The fasting uric acid levels were significantly higher in the risperidone group than in the risperidone-naïve group (5.70 vs. 5.35 mg/dl, P = 0.01). The increased uric acid concentrations were significantly associated with adolescent patients treated with risperidone. The higher dose of risperidone and/or the longer treatment time were associated with the increased uric acid levels. Uric acid levels significantly rose with body mass index (BMI), waist circumference (WC), triglyceride (TG) levels, triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C), insulin levels, homeostatic model assessment index (HOMA-IR), high-sensitivity CRP (hs-CRP) levels, and leptin levels. Conversely, the levels of HDL-C and adiponectin were negatively correlated with uric acid levels. In multiple regression analysis, there were age, BMI, TG/HDL-C ratio, and adiponectin levels remained significantly associated with uric acid levels.Conclusion: Hyperuricemia may play a role in metabolic adverse effect in children and adolescents with ASDs receiving the high dose and/or the long-term treatment with risperidone.

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“…These effects are similar in human primary subcutaneous adipocytes [27]. Clinical evidence has revealed a negative correlation between the levels of uric acid and adiponectin in the serum [60]. A strong positive association between serum leptin and uric acid has been demonstrated in both diabetic and healthy subjects [61]; however, this biochemical mechanism still needs further clarification.…”

Section: Adipose Tissuementioning

confidence: 89%

Uric acid as a modulator of glucose and lipid metabolism

2015

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Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

Abstract: Objective Visceral fat accumulation is an underlying component of the metabolic syndrome (MetS

Cited by 92 publications

References 43 publications

Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis

Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis

Hyperuricemia in Children and Adolescents with Autism Spectrum Disorder Treated with Risperidone: The Risk Factors for Metabolic Adverse Effects

Uric acid as a modulator of glucose and lipid metabolism

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