2003
DOI: 10.1016/s0957-4166(03)00164-2
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Relationship between the time, yield, and enantiomeric excess of asymmetric autocatalysis of chiral 2-alkynyl-5-pyrimidyl alkanol with amplification of enantiomeric excess

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Cited by 127 publications
(73 citation statements)
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References 33 publications
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“…Beyond the qualitative reproduction of the main striking properties of the Soai reaction, model 1 has been proved to reproduce well the shape of experimentally obtained kinetic curves (19,21) showing the formation of the chiral product with characteristic induction periods that depend on the initial catalyst concentrations and that are followed by a steep increase in product formation.…”
Section: Resultsmentioning
confidence: 82%
See 1 more Smart Citation
“…Beyond the qualitative reproduction of the main striking properties of the Soai reaction, model 1 has been proved to reproduce well the shape of experimentally obtained kinetic curves (19,21) showing the formation of the chiral product with characteristic induction periods that depend on the initial catalyst concentrations and that are followed by a steep increase in product formation.…”
Section: Resultsmentioning
confidence: 82%
“…From the various attempts of kinetic modeling (19)(20)(21)(22)(23), it appears that autocatalysis and mutual inhibition are the necessary ingredients for the Soai reaction to describe the observed chiral amplification. However, reports using these approaches have not discussed the origin of the experimentally observed mirror-symmetry breaking so far.…”
mentioning
confidence: 99%
“…On the contrary, when the rate of back reaction is too small, the enatiometric amplification can take place, but the final selection of chirality should take a long time. This might be the reason that the previous experiments by Soai et al 13,14 are well fitted by a model with only the forward autocatalytic reaction. To observe the effect of back reaction, one might have to wait a long time, depending on the back-reaction rate.…”
Section: (C) To (D)mentioning
confidence: 90%
“…is assumed to hold. The model is motivated by the chemical reaction system discovered by Soai et al, 6,7 which is the first example of chemical reaction to show the amplification of enantiomeric excess in a closed system. Chiral symmetry breaking, however, is found not only in biological and chemical systems, but also in other systems such as in crystallization.…”
mentioning
confidence: 99%