Relationship between the use of benzodiazepines and falls in older adults: A systematic review

Díaz-Gutiérrez, Ma José; Martínez‐Cengotitabengoa, Mónica; Adana, Estibaliz Sáez de; Cano, Ana Isabel; Martínez-Cengotitabengoa, Maria Teresa; Besga, Ariadna; Segarra, Rafael; González‐Pinto, Ana

doi:10.1016/j.maturitas.2017.04.002

Cited by 92 publications

(71 citation statements)

References 38 publications

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“…Since sleep disorders are more common as people age, there is a tendency for more sleeping drugs corresponding to PIMs to be prescribed to the elderly [23]. Benzodiazepines, the most commonly used sleeping medication, are known to increase the risk of falling among the elderly, therefore, it is recommended that a different sleeping drug be prescribed whenever possible [24,25]. However, since benzodiazepines are habit-forming, it is often difficult for patients to stop their use immediately.…”

Section: Discussionmentioning

confidence: 99%

Prescription of potentially inappropriate medications in elderly outpatients: a survey using 2015 Japanese Guidelines

et al. 2020

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Background In recent years, rapid increase of elderly population has become a major social problem in developed countries. They tend to receive an increasing number of prescibed drugs due to multiple illnesses, which might include inappropriate medications, in turn leading to health hazards and rising healthcare cost. Objective To evaluate the current status of potentially inappropriate medications prescribed for elderly outpatients and filled by dispensing pharmacies using the recent Japanese Guidelines, and to determine factors that are related to prescribing potentially inappropriate medications. Setting A crosssectional study of older patients (≥ 75 years) who visited dispensing pharmacies in the Ibaraki Prefecture, Japan. Method We identified patients prescribed potentially inappropriate medications using the "List of Medications that Require Particularly Careful Administration" in the Guidelines (Guideline List). We explored patient's factors related to polypharmacy (≥ 5 medications) and prescription of inappropriate medications through multivariate analysis, and a cutoff value for predicting potentially inappropriate medications through receiver operating characteristic curve analysis. Main outcome measure Prevalence of polypharmacy and potentially inappropriate medications, and patient's factors associated with them. Results Of 8080 patients (39,252 medications) who visited pharmacies during the study period, 43.1% (3481) were prescribed ≥ 5 medications. In total, 2157 patients (26.7%) were prescribed at least one potentially inappropriate medication. The most prescribed inappropriate medication class was (benzodiazepine) sedatives and hypnotics. Potentially inappropriate medications were 7.11 times (95% CI 6.29-8.03) and 1.51 times (1.34-1.71) more likely to be prescribed for patients with ≥ 5 medications and those prescribed by multiple physicians, respectively. A cutoff value for potentially inappropriate medications was found to be five for the total number of medications and four for the number of chronic medications with a systemic effect. Conclusion Prescription of potentially inappropriate medications was increased among patients with ≥ 5 medications and those chronically prescribed ≥ 4 medications with a systemic effect. The Guideline List should be actively used to screen such patients, and to carefully examine prescriptions. Particular care should be exercised when patients are visiting multiple physicians.

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Section: Discussionmentioning

confidence: 99%

Prescription of potentially inappropriate medications in elderly outpatients: a survey using 2015 Japanese Guidelines

et al. 2020

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“…Their use is associated with falls and fractures [4,5,28,29]. Prescribing benzodiazepines are best accomplished with specific indications, time-limited applications, lower dosages, and short drug elimination half-lives [30].…”

Section: Treatmentmentioning

confidence: 99%

Anxiety in geriatrics

Pary

Sarai

Sumner

et al. 2019

Postgraduate Medicine

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“…A fall incident is an indication of the quality of life and quality of care of old er adults. Risk factors for falls are oft en complex; however, studies reveal that BZD use is related to high falls incidents among older adults (Díaz-Gutiérrez et al, 2017). Th erefore, avoiding inappropriate use of BZDs may substantially decrease fall-related incidents in older adults.…”

Section: Benzodiazepine Use and Falls In Older Adultsmentioning

confidence: 99%