Relationship between Thyroid Functions and Urinary Growth Hormone Secretion in Patients with Hyper- and Hypothyroidism.

Murao, Koji; Takahara, Jiro; Sato, Makoto; Tamaki, Miho; Niimi, Michio; Ishida, Toshihiko

doi:10.1507/endocrj.41.517

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Several studies have found a decreased response of GH to GHRH stimulation in hyperthyroidism [46][47][48], which normalised after treatment with antithyroid drugs to euthyroidism. In one of the studies, hyperthyroidism was hypothesised to accelerate urinary GH clearance [48], while another found elevated serum IGF-I levels and therefore suggested an altered neuroregulation of GH secretion.…”

Section: Effect Of Thyroid Function On Growth Hor-mone Axismentioning

confidence: 99%

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Interactions Between Growth Hormone and the Thyroid Gland - with Special Reference to Biochemical Diagnosis

Feldt‐Rasmussen

2007

CMC

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The diagnosis of pituitary disorders is difficult because several hormone systems are involved. The clinical presentation is often vague and slowly progressing, and clinicians therefore have to rely very much on correct biochemical measurements. This is also associated with difficulties since the pituitary hormones interact, the binding proteins are influenced by the other axes and a variety of other effects, and finally the hormone measurements in serum are not totally adequate Several studies have investigated the interaction between the thyroid and growth hormone axes with very variable results. The present review is focussing on the aspects related to clinical decision making based on biochemical assessments. Because of the strong and sometimes unpredictable interrelations between the hypothalamo-pituitary thyroid and the hypothalamo-GH-IGF axes, and the many pitfalls in the measurement of peripheral hormones and interpretation of stimulation tests, clinicians and clinical biochemists should collaborate closely. Only then can the diagnostic accuracy and the management of patients with both growth hormone and thyroid disorders be improved.

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Section: Effect Of Thyroid Function On Growth Hor-mone Axismentioning

confidence: 99%

“…In one of the studies, hyperthyroidism was hypothesised to accelerate urinary GH clearance [48], while another found elevated serum IGF-I levels and therefore suggested an altered neuroregulation of GH secretion. TRH did not seem to be involved in this process [46].…”

Section: Effect Of Thyroid Function On Growth Hor-mone Axismentioning

confidence: 99%

Interactions Between Growth Hormone and the Thyroid Gland - with Special Reference to Biochemical Diagnosis

Feldt‐Rasmussen

2007

CMC

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“…Elsewhere, the correlation between blood and urinary hGH levels was variable[30] and seemed to be impaired by factors such as sex (no correlation in males[31]), and disease state (no correlation in children with hGH deficiency,[32] individuals with thyroid disfunction,[33] renal insufficiency[16]).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle technology: amplifying the effective sensitivity of biomarker detection to create a urine test for hGH

Fredolini

Tamburro

Gambara

et al. 2009

Drug Testing and Analysis

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While several clinical grade immunoassays exist for the specific measurement of hGH, or its isoforms in blood, there is an urgent need to apply these same reliable assays to the measurement of hGH in urine as a preferred non invasive biofluid. Unfortunately, conventional hGH immunoassays can not attain the required sensitivity to detect the low concentrations of hGH in urine. The lowest limit of sensitivity for existing hGH immunoassays is >50 pg/mL, while the estimated concentration of urinary hGH is about one pg/mL: fifty times lower than the sensitivity threshold. We have created novel N-isopropylacrylamide (NIPAm) based hydrogel nanoparticles functionalized with an affinity bait. When introduced into an analyte containing solution, the nanoparticles can perform, in one step, in solution, a) complete harvesting of all solution phase target analytes, b) fully protect the captured analyte from degradation and c) sequester the analyte and effectively increase the analyte concentration up to 100 fold. NIPAm nanoparticles functionalized with Cibacron Blue F3GA bait have been applied to raise the concentration of urinary hGH into the linear range of clinical grade immunoassays. This technology now provides an opportunity to evaluate the concentration of hGH in urine with high precision and accuracy.

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The role of somatostatin (octreotide) in the regulation of melatonin secretion in healthy volunteers and in patients with primary hypothyroidism

Wikner

Wetterberg

Röjdmark

1999

J Endocrinol Invest

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Somatostatin has been found in the pineal gland of several animal species, which suggests that it may be involved in the regulation of melatonin secretion. Whether somatostatin has regulatory influence on melatonin secretion in man has never been unequivocally shown. We studied the nocturnal melatonin secretion in 8 healthy volunteers, and 6 women with untreated primary hypothyroidism, a disease state that is associated with increased nocturnal secretion of melatonin. The participants were given subcutaneous injections at 18:00 h and 23:00 h of either saline or octreotide (Sandostatin; each injection 50 microg). During the nights when the healthy volunteers were given octreotide, melatonin secretion was similar to that recorded during administration of saline. Also the urinary excretion of melatonin was of similar magnitude at these two occasions. By contrast, the GH secretion was significantly lower the nights the healthy controls were given octreotide (GH AUC 22.6+/-5.4 mU/l x h during octreotide and 126.6+/-21.9 mU/l x h during saline; p<0.01). The patients with hypothyroidism also showed similar nocturnal melatonin secretion during octreotide and saline. Urinary excretion of melatonin also remained unchanged, as did GH secretion. The total nocturnal secretion of TSH was, however, significantly reduced by octreotide (TSH AUC 562+/-136 mU/l x h during octreotide and 851+/-185 mU/l x h during saline; p<0.05), thus suggesting that 100 microg of octreotide should be sufficient to inhibit also the pinealocytes if their function were regulated by somatostatin. Since exogenous somatostatin--in the form of octreotide--fails to influence nocturnal secretion and urinary excretion of melatonin in normal subjects and in patients with primary hypothyroidism, it is reasonable to assume that endogenous somatostatin may not be an important regulator of melatonin secretion in man.

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Relationship between Thyroid Functions and Urinary Growth Hormone Secretion in Patients with Hyper- and Hypothyroidism.

Cited by 4 publications

References 24 publications

Interactions Between Growth Hormone and the Thyroid Gland - with Special Reference to Biochemical Diagnosis

Interactions Between Growth Hormone and the Thyroid Gland - with Special Reference to Biochemical Diagnosis

Nanoparticle technology: amplifying the effective sensitivity of biomarker detection to create a urine test for hGH

The role of somatostatin (octreotide) in the regulation of melatonin secretion in healthy volunteers and in patients with primary hypothyroidism

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