Relationship between thyroid hormone and sex hormone levels and non-suicidal self-injury in male adolescents with depression

Ma, Junying; Zhao, Mingming; Niu, Gengyun; Wang, Zhifei; Jiang, Shan; Liu, Zengxun

doi:10.3389/fpsyt.2022.1071563

Cited by 8 publications

(5 citation statements)

References 54 publications

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“…This endeavor stems from the existing scarcity of dependable biomarkers in this domain. The association between thyroid dysfunction and depression has long been established, with some experts postulating that thyroid hormones may be involved in the underlying neurobiological mechanisms of suicidal behavior [15]. Additionally, several studies have reported a correlation between lipid abnormalities and suicidality [16].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram for suicide attempts in patients with first-episode drug- naïve major depressive disorder

Liu,

Tong,

et al. 2024

Preprint

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Objective: The risk of suicide can be decreased by accurately identifying high-risk suicide groups and implementing the right interventions. The aim of this study was to develop a predictive nomogram for suicide attempts (SA) in patients with first-episode drug-naïve (FEDN) major depressive disorder (MDD). Methods: A cross-sectional investigation was conducted, enrolling 1,718 patients diagnosed with FEDN MDD who provided comprehensive clinical data between September 2016 and December 2018. Anthropometric and sociodemographic data were collected from the participants. The severity of depression and anxiety in all subjects was assessed using the 17-item Hamilton Depression Scale (HAMD-17) and the Hamilton Anxiety Scale (HAMA), respectively. Additionally, thyroid hormone levels, lipid profile parameters, and fasting blood glucose (FBG) were measured. The confirmation of SA history relied on an amalgamation of medical records, patient interviews, and family interviews. Random allocation assigned participants to either the training group (70%, n = 1,204) or the validation group (30%, n = 514). In the training group, LASSO analysis and multivariate regression were employed to identify the relevant variables associated with SA. Subsequently, a nomogram was developed based on the selected risk factors to predict the probability of SA within the training group. To assess the accuracy of the prediction, the area under the receiver operating characteristic curve (AUC) was utilized, and calibration plots were employed to evaluate calibration. Additionally, decision curve analysis (DCA) was performed to assess the precision of the prediction model. Finally, internal validation was carried out using the validation group. Results: We have successfully developed a readily applicable nomogram that utilizes HAMD, HAMA, thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and systolic blood pressure (SBP) parameters to forecast the likelihood of SA in Chinese patients with FEDN MDD. In both our training and validation groups, the pooled area under the ROC for SA risk was determined to be 0.802 (95% CI: 0.771 to 0.832) and 0.821 (95% CI: 0.774 to 0.868), respectively. Calibration analysis demonstrated a favorable alignment between the predicted probabilities from the nomogram and the actual probabilities. Decision curve analysis confirmed the clinical utility of the nomogram. To facilitate the utilization of the nomogram by clinicians and researchers, an online version is available at https://doctorjunjunliu.shinyapps.io/dynnomapp/. Conclusions: We constructed and validated a nomogram capable of early identification of FEDN MDD patients with a high risk of SA, thereby contributing to the implementation of effective suicide prevention programs.

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Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram for suicide attempts in patients with first-episode drug- naïve major depressive disorder

Liu,

Tong,

et al. 2024

Preprint

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“…A comprehensive meta-analysis of 12,315 individuals indicated that patients with subclinical hypothyroidism have a higher risk of depression compared to euthyroid controls (relative risk of 2.35, 95% CI: 1.84 to 3.02, p < 0.001) ( 7 ). Depression-related thyroid hormone (TH) level changes include increased reversed triiodothyronine (rT3) ( 8 , 9 ) and decreased circulating T3 and TSH levels ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

The Thr92Ala polymorphism in the type 2 deiodinase gene is linked to depression in patients with COVID-19 after hospital discharge

Beltrão,

Carvalhal

et al. 2024

Front. Endocrinol.

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BackgroundThe Thr92Ala-DIO2 polymorphism has been associated with clinical outcomes in hospitalized patients with COVID-19 and neuropsychiatric diseases. This study examines the impact of the Thr92Ala-DIO2 polymorphism on neuropsychological symptoms, particularly depressive symptoms, in patients who have had moderate to severe SARS-CoV-2 infection and were later discharged.MethodsOur prospective cohort study, conducted from June to August 2020, collected data from 273 patients hospitalized with COVID-19. This included thyroid function tests, inflammatory markers, hematologic indices, and genotyping of the Thr92Ala-DIO2 polymorphism. Post-discharge, we followed up with 68 patients over 30 to 45 days, dividing them into depressive (29 patients) and non-depressive (39 patients) groups based on their Beck Depression Inventory scores.ResultsWe categorized 68 patients into three groups based on their genotypes: Thr/Thr (22 patients), Thr/Ala (41 patients), and Ala/Ala (5 patients). Depressive symptoms were less frequent in the Thr/Ala group (29.3%) compared to the Thr/Thr (59.1%) and Ala/Ala (60%) groups (p = 0.048). The Thr/Ala heterozygous genotype correlated with a lower risk of post-COVID-19 depression, as shown by univariate and multivariate logistic regression analyses. These analyses, adjusted for various factors, indicated a 70% to 81% reduction in risk.ConclusionOur findings appear to be the first to show that heterozygosity for Thr92Ala-DIO2 in patients with COVID-19 may protect against post-COVID-19 depression symptoms up to 2 months after the illness.

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“…This endeavor stems from the existing scarcity of dependable biomarkers in this domain. The association between thyroid dysfunction and depression has long been established, with some experts postulating that thyroid hormones may be involved in the underlying neurobiological mechanisms of suicidal behavior ( 9 ). Additionally, several studies have reported a correlation between lipid abnormalities and suicidality ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram for suicide attempts in patients with first-episode drug-naïve major depressive disorder

Liu,

Tong,

et al. 2024

Front. Psychiatry

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ObjectiveThe risk of suicide can be decreased by accurately identifying high-risk suicide groups and implementing the right interventions. The aim of this study was to develop a nomogram for suicide attempts (SA) in patients with first-episode drug-naïve (FEDN) major depressive disorder (MDD).MethodsThis study undertook a cross-sectional analysis of 1,718 patients diagnosed with FEDN MDD, providing comprehensive clinical data from September 2016 to December 2018. Data on anthropometric and sociodemographic factors were gathered, and the severity of depression and anxiety was evaluated using the 17-item Hamilton Depression Scale (HAMD-17) and the Hamilton Anxiety Scale (HAMA), respectively. Additionally, thyroid hormone levels, lipid profile parameters, and fasting blood glucose (FBG) were measured. Suicide attempt (SA) history was verified based on an amalgamation of medical records, patient interviews, and family interviews. Participants were randomly divided into a training group (70%, n = 1,204) and a validation group (30%, n = 514). In the training group, LASSO analysis and multivariate regression were used to identify variables associated with SA. A nomogram was then constructed using the identified risk factors to estimate the likelihood of SA within the training group. To assess the accuracy, the area under the receiver operating characteristic curve (AUC) was utilized, and calibration plots were employed to evaluate calibration. Additionally, decision curve analysis (DCA) was performed to assess the precision of the model. Finally, internal validation was carried out using the validation group.ResultsA practical nomogram has been successfully constructed, incorporating HAMD, HAMA, thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and systolic blood pressure (SBP) parameters, to estimate the probability of SA in Chinese patients diagnosed with FEDN MDD. The pooled area under the ROC for SA risk in both the training and validation groups was found to be 0.802 (95% CI: 0.771 to 0.832) and 0.821 (95% CI: 0.774 to 0.868), respectively. Calibration analysis revealed a satisfactory correlation between the nomogram probabilities and the actual observed probabilities. The clinical applicability of the nomogram was confirmed through decision curve analysis. To enhance accessibility for clinicians and researchers, an online version of the nomogram can be accessed at https://doctorjunjunliu.shinyapps.io/dynnomapp/.ConclusionsWe constructed and validated a nomogram for the early detection of FEDN MDD patients with a high risk of SA, thereby contributing to the implementation of effective suicide prevention programs.

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Relationship between thyroid hormone and sex hormone levels and non-suicidal self-injury in male adolescents with depression

Cited by 8 publications

References 54 publications

Development and validation of a nomogram for suicide attempts in patients with first-episode drug- naïve major depressive disorder

Development and validation of a nomogram for suicide attempts in patients with first-episode drug- naïve major depressive disorder

The Thr92Ala polymorphism in the type 2 deiodinase gene is linked to depression in patients with COVID-19 after hospital discharge

Development and validation of a nomogram for suicide attempts in patients with first-episode drug-naïve major depressive disorder

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