Relationship between thyroid hormones, resting energy expenditure and cardiometabolic risk factors in euthyroid subjects

Spadafranca, Angela; Cappelletti, Chiara; Vignati, Laila; Battezzati, Alberto; Bedogni, Giorgio; Bertoli, Simona

doi:10.1016/j.clnu.2014.07.014

Cited by 30 publications

(26 citation statements)

References 27 publications

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“…This contention is supported by our lack of association recorded between TSH and BMI, in contrast with the significant positive relationship recorded between these two variables by Knudsen et al [13]. Recently, Spadafranca et al [9] have also reported no association between REE and TSH in mostly overweight or obese euthyroid subjects. …”

Section: Discussioncontrasting

confidence: 56%

“…While it is well accepted that individual fat free mass (FFM) is a prime factor in determining RMR [1,3,7], less is known about the potential impact of basal blood hormones such as thyroid stimulating hormone (TSH), cortisol and insulin on RMR. While some reports of the impact of these hormones on RMR and weight management are located in the literature in isolation [1,8,9], the combined impact of these variables on RMR has not been widely reported. If chronic abnormal concentrations of these hormones exist, and RMR is negatively affected, weight gain may be promoted or, perhaps more importantly, losing weight may be made more difficult.…”

Section: Introductionmentioning

confidence: 99%

“…However, the effect of TSH on RMR remains unclear. Resting energy expenditure (REE) was found to correlate with TSH in patients receiving chronic thyroxine treatment when their thyroxine doses were altered [8], but no relationship was reported between REE and TSH in mostly overweight and obese euthyroid persons [9]. Therefore, the relationship between TSH and RMR requires further investigation, although it has been suggested that RMR is only 20-25% thyroid-dependent in humans [8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of Hormonal Profile on Resting Metabolic Rate in Normal, Overweight and Obese Individuals

Wright¹,

Dawson

Jalleh³

et al. 2015

Ann Nutr Metab

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Aims: To investigate whether blood thyroid stimulating hormone (TSH), cortisol, insulin and glucose concentrations (plus glucose:insulin ratio; GIR) could improve the accuracy of resting metabolic rate (RMR) prediction in normal, overweight and obese persons. Methods: Predictive equations were developed and compared against indirect calorimetry measures for RMR in 217 weight-control clinic participants (n = 128 males and n = 89 females: ∼24% normal weight, ∼39% overweight and ∼37% obese). Results: Using the common accuracy criteria of the proportion of predicted RMR within ±10% of measured RMR, our equations (using age, height, weight and gender, plus the blood factors, both independently and in combination) were accurate ∼36-44% of the time, for the whole sample, and when separated by gender and weight class. Specifically, the addition of the blood hormone and glucose concentrations improved the accuracy of predicted RMR by only 1-8% (NS). Conclusions: Including blood TSH, cortisol, insulin, glucose and GIR into RMR prediction equations did not significantly improve estimation accuracy, which in any case only met a criterion of ±10% of the measured RMR ∼40% of the time. Further work to refine the prediction of RMR is still needed, and at present, direct measurements should be made wherever possible.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Hormonal Profile on Resting Metabolic Rate in Normal, Overweight and Obese Individuals

Wright¹,

Dawson

Jalleh³

et al. 2015

Ann Nutr Metab

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“…In our study, TSH also did not prove to be independently associated with REE adj when BMI was included in the multiple stepwise regression, as opposed to body composition variables (data not shown). Therefore, the use of BMI instead of FFM as the most important predictor of REE may explain the divergence between the above-mentioned results [23] and our study.…”

Section: Discussioncontrasting

confidence: 52%

“…Another study did not observe an association between TSH and REE in 664 female and 221 male euthyroid subjects between 18 and 79 years, with a median BMI of 28.6 kg/m 2 [23] . One reason for the lack of an observed association between TSH and REE in their multiple regression analysis may be that BMI opposed to body composition variables was considered a covariate.…”

Section: Discussionmentioning

confidence: 99%

Association of Thyroid-Stimulating Hormone with Resting Energy Expenditure in Euthyroid Elderly Subjects: A Cross-Sectional Study

Nagel

Spinneker²,

Neuhäuser‐Berthold³

2015

Ann Nutr Metab

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Background: Several studies have reported positive correlations between thyroid-stimulating hormone (TSH) and body mass index (BMI) in euthyroid subjects. As impaired thyroid function is known to affect the metabolic rate, this study investigated whether TSH is associated with resting energy expenditure (REE) in euthyroid elderly subjects, independent of age, anthropometric data and body composition. Methods: Cross-sectional data of 77 women (66-96 years, BMI 18-36 kg/m²) and 55 men (66-86 years, BMI 20-39 kg/m²) were analyzed. REE was measured using indirect calorimetry, body composition by bioelectrical impedance analysis and serum TSH using an electrochemiluminescence immunoassay. Results: REE, fat-free mass (FFM) and waist circumference (WC) were significantly lower, whereas TSH and fat mass (FM) were significantly higher in women than in men. In multiple stepwise regression analysis, with age-adjusted REE (REE_adj) as the dependent variable and FFM, FM and WC as independent variables, FFM and WC explained 40.7% in women and FFM 32.8% in men of the variability in REE_adj. Including TSH in the model led to a significant rise of the adjusted R-squared value in women only, and explained an additional 2.8% of the variability in REE_adj. Conclusions: TSH is independently and negatively associated with REE in euthyroid elderly women.

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Thyroid and Obesity

Geronimo

2021

Thyroid, Obesity and Metabolism

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Relationship between thyroid hormones, resting energy expenditure and cardiometabolic risk factors in euthyroid subjects

Cited by 30 publications

References 27 publications

Influence of Hormonal Profile on Resting Metabolic Rate in Normal, Overweight and Obese Individuals

Influence of Hormonal Profile on Resting Metabolic Rate in Normal, Overweight and Obese Individuals

Association of Thyroid-Stimulating Hormone with Resting Energy Expenditure in Euthyroid Elderly Subjects: A Cross-Sectional Study

Thyroid and Obesity

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