Relationship Between TLR2 and TLR4 Gene Polymorphisms with Psoriasis

Keni, Fatih Mehmet; Çelik, Sevim; Solak, Nilgün; Genç, Güneş Çakmak; Dursun, Ahmet

doi:10.4274/tdd.3508

Cited by 2 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SNPs can be found in the coding, intergenic and non-coding regions of genes or promoters [ 10 ]. In studies related to gene polymorphisms in psoriasis, a significant relationship has been found in some genes [ 11 – 14 ]. In different studies performed, the polymorphisms of interleukins IL-1β , IL-6 , IL-10 , IL-16 and IL-17A have also been demonstrated to be associated with the pathogenesis of psoriasis [ 15 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the relationship of IL17A and IL17F gene polymorphisms with the response to treatment in psoriatic patients using biological drugs: case-control study in patients in eastern Turkey

Özkol¹,

Görgişen²,

Ateş³

et al. 2021

pdia

View full text Add to dashboard Cite

Introduction IL-17A and IL-17F cytokines have important roles in the pathogenesis of psoriasis. Aim To examine the associations of IL-17A rs2275913 and IL-17F rs763780 variants with the development of psoriasis and whether these polymorphisms affect the responsiveness of biological agents. Material and methods In our case-controlled study, which included 83 psoriatic patients who were treated with different biological agents and 69 healthy controls, we genotyped IL-17A rs2275913 and IL-17F rs763780 variants using TaqMan probes. Results We did not observe statistically significant changes in genotype frequencies of IL-17A rs2275913 ( p = 0.922) and IL-17F rs763780 ( p = 0.621) variants between patient and control groups. Although we did not find any association between these polymorphisms and the development of psoriasis, statistical analyses showed that individuals with the IL-17A AA genotype had shorter disease duration (9.09 ±6.82, p = 0.020) and AA genotype frequency was higher in patients who used single conventional treatment (34.6%; p = 0.025). IL17A/rs2275913 variant in terms of disease duration, it was observed that individuals with AA genotype had a shorter disease duration (less than 10 years) ( p = 0.009). For patients with PASI90 and PASI100 response, the IL-17A AA genotype was significantly higher ( p = 0.015). On the other hand, we did not detect any statistically significant correlation between variants and response to biological agents. Conclusions According to our results, we may suggest that rs2275913 variant seems to be associated with disease duration, use of single conventional treatment and responsiveness of PASI90 and PASI100 however both variants have no effect on the susceptibility to psoriasis in the population of Eastern Turkey.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of the relationship of IL17A and IL17F gene polymorphisms with the response to treatment in psoriatic patients using biological drugs: case-control study in patients in eastern Turkey

Özkol¹,

Görgişen²,

Ateş³

et al. 2021

pdia

View full text Add to dashboard Cite

show abstract

Psoriasis: An Immunogenetic Perspective

Kocaaga

2022

Glob Med Genet

View full text Add to dashboard Cite

Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease. Over the past two decades, numerous linkage analyzes and genome-wide association studies have been conducted to investigate the role of genetic variation in disease pathogenesis and progression. To date, >70 psoriasis susceptibility loci have been identified, including HLA-Cw6, IL12B, IL23R, and LCE3B/3C. Some genetic markers are used in clinical diagnosis, prognosis, treatment, and personalized new drug development that can further explain the pathogenesis of psoriasis. This review summarizes the immunological mechanisms involved in the etiopathogenesis of psoriasis and recent advances in susceptibility genes and highlights new potential targets for therapeutic intervention.

show abstract

Relationship Between TLR2 and TLR4 Gene Polymorphisms with Psoriasis

Cited by 2 publications

References 11 publications

Evaluation of the relationship of IL17A and IL17F gene polymorphisms with the response to treatment in psoriatic patients using biological drugs: case-control study in patients in eastern Turkey

Evaluation of the relationship of IL17A and IL17F gene polymorphisms with the response to treatment in psoriatic patients using biological drugs: case-control study in patients in eastern Turkey

Psoriasis: An Immunogenetic Perspective

Contact Info

Product

Resources

About