Relationship between total cholesterol/high-density lipoprotein cholesterol ratio, triglyceride/high-density lipoprotein cholesterol ratio, and high-density lipoprotein subclasses

Lu, Jia; Long, Shiyin; M, Fu; Yan, Bingyu; Tian, Ying; Xu, Yu; Gou, Lantu

doi:10.1016/j.metabol.2006.04.004

Cited by 59 publications

(62 citation statements)

References 32 publications

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“…This specific particle is an atherogenic lipoprotein with high capacity to promote oxidative modifications [12], but its requires highly sophisticated techniques to evaluate its size, and TG/HDL-C has been shown to be correlated to this specific size of LDL-C [13,14].…”

Section: Introductionmentioning

confidence: 99%

Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?

Oliveira¹,

Oliveira²,

Oliveira³

et al. 2013

Health

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As elevated triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been described as predictor for cardio metabolic disease with insulin resistance (IR) in the background, the aim was to assess the relationship between this ratio and IR in youth. Oral glucose tolerance test was performed in 318 Brazilian students (175 girls, 11.2 ± 3.2 years, BMI_z-score 1.2 ± 1.4 SD). Measurements: BMI, waist circumference (WC), blood pressure (BP), lipids, insulin and high sensitivity C-reactive protein (hsCRP). Excessive weight and abdominal obesity were defined using BMI_z-score and WC and IR by Homeostasis model assessment-insulin resistance (HOMA-IR). TG/HDL-C median was 2.37. There was an association between TG/ HDL-C and WC, systolic and diastolic BP, insulin, HOMA-IR, hsCRP, (p < 0.001). Stratified TG/HDL-C into two groups, based on a cut off point of 2.73 (Group 1: <2.73 and Group 2: ≥2.73). Adjusting for age, gender, ethnicity TG/HDL-C was an independent variable predicting IR (PR = 1.44; CI: 1.07 -1.96; p = 0.018). For every 1 (cm) in WC increased there was an addition of 0.04 of the value of TG/HDL-C and in those with TG/HDL-C ≥ 2.73 for every 10 (cm) increase in WC there was an improve of 4% in the ratio. In conclusion: In youth, the TG/HDL-C ratio could be a useful index for identifying groups with IR.

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Section: Introductionmentioning

confidence: 99%

Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?

Oliveira¹,

Oliveira²,

Oliveira³

et al. 2013

Health

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“…These parameters did not influence significantly the HDL size in this study. Some studies have shown that small HDL particles (HDL 3 ) contribute to increased cardiovascular risk, whereas the large HDL particles (HDL 2 ) are associated with a decreased risk and they have potent antiatherogenic properties [9] [21]. The HDL's particle size has been a target of many studies based on evaluation of cardiovascular risk.…”

Section: Discussionmentioning

confidence: 99%

Atherogenic Indices and HDL Particle Size as Laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of Dyslipidemia

Santos¹,

Vieira²,

Deus³

et al. 2014

JBPC

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Dyslipidemia may influence enzymes and transfer proteins needed to the lipoprotein particle remodeling. Calculated indices and evaluation of lipoprotein particle size have widely been used to predict cardiovascular risk. The aim of this study was to evaluate HDL particle size and LDL particle size estimate based on TG/HDL-C as well as apoB/apoA-I ratio as possible marker and atherogenic indices, respectively, of cardiovascular disease risk in the presence of dyslipidemia. We evaluated 100 individuals of both gender, without treatment with lipid-lowering drugs, 27 normolipidemic and 73 dyslipidemic, such as isolated hypercholesterolemia (n = 16), isolated A. P. C. Santos et al. 25hypertriglyceridemia (n = 17), low HDL-C (n = 26) and mixed dyslipidemia (n = 14). The HDL particle size did not differ between groups. The TG/HDL-C ratio was higher in groups with isolated hypertriglyceridemia (4.2 ± 1.5), low HDL-C (5.2 ± 3.1) and mixed dyslipidemia (5.3 ± 1.6). The apoB/apoA-I ratio was increased in all groups of dyslipidemia (apoB/apoA-I > 0.5) when compared to normolipidemic (apoB/apoA-I = 0.5, p < 0.001). There was a positive linear correlation between the TG/HDL-C ratio and the apoB/apoA-I ratio in low HDL-C group (r = 0.507, p = 0.008, Spearman). The results suggest that the evaluations of lipoproteins particles remodeling markers and the use of calculated indices may contribute to the evaluation of cardiovascular disease risk when dyslipidemia take place.

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“…Many studies, including prospective epidemiologic studies, have shown that an increased TG/ HDL-C level was correlated with small dense LDL particles, phenotype B, which is associated with an elevated risk of coronary heart disease [4,33]. In contrast, low TG/HDL-C and low TC/HDL-C levels were correlated with increased large-size HDL subclasses [5], which have anti-atherogenic functions by reverse cholesterol transport [34]. According to recent meta-analyses, TC/HDL-C level is also an important predictor of the risk of CVD [35,36].…”

Section: Discussionmentioning

confidence: 99%

Low bone mineral density is associated with dyslipidemia in South Korean men: The 2008–2010 Korean National Health and Nutrition Examination Survey

et al. 2013

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Relationship between total cholesterol/high-density lipoprotein cholesterol ratio, triglyceride/high-density lipoprotein cholesterol ratio, and high-density lipoprotein subclasses

Cited by 59 publications

References 32 publications

Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?

Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?

Atherogenic Indices and HDL Particle Size as Laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of Dyslipidemia

Low bone mineral density is associated with dyslipidemia in South Korean men: The 2008–2010 Korean National Health and Nutrition Examination Survey

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