Relationship between TSH and free thyroxine in outpatient cancer patient population

Alkhalaileh, Hussam; Wei, Ruhan; Lee, Jason K.Y.; Jones, JoAnna; Li, Jieli

doi:10.1007/s12020-023-03399-3

Cited by 2 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of this large cohort study is likely to be supported by two previously published observational studies conducted by Chen et al, they reported an increased risk and decreased risk of EC in patients with hypothyroidism and hyperthyroidism, although this association was not statistically significant 26 , 27 . Their findings may also be supported by a recently published retrospective study in which an inverse correlation between TSH and FT4 was observed in a cancer patient population and may indirectly explain our findings 28 . Another large cohort study published previously by Kang et al showed inconsistent results that hypothyroidism or hyperthyroidism were not significantly associated with EC or OC risk 29 .…”

Section: Discussionsupporting

confidence: 90%

Hypothyroidism and hyperthyroidism related to gynecologic cancers: a nationwide population-based cohort study

Leung,

Wang,

Leung

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The purpose of this study was to assess the risks of hyperthyroidism and hypothyroidism related to gynecological cancers. Population-based retrospective cohort study. We conducted a cohort study using the Taiwan National Health Insurance Research Database to explore hyperthyroidism and hypothyroidism associated with site-specific gynecologic cancers in women from January 1, 2000 to December 31, 2018. The examined gynecologic cancers included endometrial (EC), uterine corpus cancer (UC), and ovarian cancer (OC). The incidence and hazard ratios were quantified using Cox proportional hazards models. The incidence of developing gynecological (Gyn) cancers in the hyperthyroid and hypothyroid women was 0.29 and 0.44 per 1000 person-years, which was 0.86 fold lower and 1.13 fold higher than that in the comparison cohort (p < 0.001). Compared with patients aged 20–40 years, patients in older age groups had a lower and higher risk of developing Gyn cancers (for hyperthyroid, 40–65 years: adjusted hazard ratio (aHR) = 0.82; > 65 years: aHR = 0.94; for hypothyroid, adjusted hazard ratio (aHR) = 1.26; > 65 years: aHR = 1.38). Compared with the non-hypothyroid women and non-hyperthyroid women beyond 6 years of follow-up, hypothyroid and hyperthyroid women showed decreased risk of Gyn cancers. Medication treatment for hyperthyroid and hypothyroid disease did not showed significant association in subgroup analyses (aHR = 0.99 and 0.80, respectively). Our results show that women with hyperthyroidism have a significantly reduced risk of gynecological cancers, whereas women with hypothyroidism have a slightly increased risk of gynecological cancers suggesting an association between thyroid function level and risk of gynecological cancers.

show abstract

Section: Discussionsupporting

confidence: 90%

Hypothyroidism and hyperthyroidism related to gynecologic cancers: a nationwide population-based cohort study

Leung,

Wang,

Leung

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…2 In clinical practice, the measurement of thyroid-stimulating hormone (TSH), tetraiodothyronine (T4), and triiodothyronine (T3) levels in the blood has been extensively studied in various diseases, including cancer, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), and acute-on-chronic liver failure. [3][4][5][6][7] In patients with diabetes and NAFLD, the levels of free triiodothyronine (FT3) and total triiodothyronine (TT3) were found to be significantly higher, while free tetraiodothyronine (FT4) was lower compared to those without NAFLD. 3 Furthermore, levels of FT3 and FT4 were significantly lower in patients with progressive liver fibrosis compared to those without progressive liver fibrosis.…”

Section: Introductionmentioning

confidence: 99%

The Free Triiodothyronine, Gamma-Glutamyl Transpeptidase and Spontaneous Bacterial Peritonitis Index: A Novel Model for Predicting 1-Year Mortality in Patients with HBV-Related Hepatic Encephalopathy

Lin,

Huang,

Liu

et al. 2024

HMER

View full text Add to dashboard Cite

Background and Aims Hepatic encephalopathy (HE) is characterized by neuropsychiatric manifestations in patients with decompensated cirrhosis (DC) and/or liver failure. This study aimed to investigate the predictive value of thyroid hormone in patients with HE. Methods Patients with DC and HE were enrolled, and multivariate logistic analysis was conducted to analyze the risk factors for 1-year mortality. Results Among the 81 patients with HBV-related DC and HE, 9 (11.1%) died within 3 months, and 15 (18.5%) died within the first year. More patients with FT3 < 3.5pmol/L had ascites (33.3% vs 8.9%, P<0.01) and higher model for end-stage liver disease (MELD) (Z=3.669, P<0.01). Additionally, free triiodothyronine (FT3) levels were lower in the non-survivor group (P<0.01). FT3 exhibited a negative correlation with international normalized ratio and MELD (both P<0.05). Multivariate analysis revealed that FT3, gamma-glutamyl transpeptidase (GGT), and spontaneous bacterial peritonitis (SBP) were independent risk factors for 1-year mortality of HE. A new model incorporating FT3, GTT, and SBP demonstrated superiority to MELD based on the AUROC (0.9 and 0.752, P=0.04). Conclusion Low FT3, but not thyroid-stimulating hormone and free tetraiodothyronine, was identified as an independent risk factor for 1-year mortality in patients with DC and HE. The newly proposed prognostic model, which includes FT3, GTT, and SBP, holds significant predictive value.

show abstract

Relationship between TSH and free thyroxine in outpatient cancer patient population

Cited by 2 publications

References 30 publications

Hypothyroidism and hyperthyroidism related to gynecologic cancers: a nationwide population-based cohort study

Hypothyroidism and hyperthyroidism related to gynecologic cancers: a nationwide population-based cohort study

The Free Triiodothyronine, Gamma-Glutamyl Transpeptidase and Spontaneous Bacterial Peritonitis Index: A Novel Model for Predicting 1-Year Mortality in Patients with HBV-Related Hepatic Encephalopathy

Contact Info

Product

Resources

About