Relationship between tumor location, size, and WHO grade in meningioma

Magill, Stephen T.; Young, Jacob S; Chae, Ricky; Aghi, Manish K.; Theodosopoulos, Philip V.; McDermott, Michael W.

doi:10.3171/2018.1.focus17752

Cited by 133 publications

(104 citation statements)

References 27 publications

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“…Another interesting aspect was observed by Magill et al, who proved in a study conducted on 1113 meningiomas (905 grade I meningiomas and 208 grade II meningiomas) that the larger the size of the tumor, the higher the risks that it would be a grade II meningioma (24). In order to explain this, Magill et al considered that there would be two possibilities: one would be that the grade II meningiomas grow faster than grade I meningiomas, and a second that once the slow growth tumor reaches a larger size, it develops a microenvironment due to hypoxia, which leads to the phenotype of this tumor becoming more aggressive (24).…”

Section: The Influence Of Tumor Volume On the Tumor Recurrence Riskmentioning

confidence: 89%

The tumour volume influence on tumour recurrence and progression-free survival in the case of atypical meningiomas

Cucu¹,

Costea²,

Turliuc³

et al. 2020

roneuro

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Objective: The objective of our study was to evaluate a possible relation between the volume of atypical meningiomas (AMs) and the risk of tumour recurrence, as well as progression-free survival (PFS). Material and methods: We evaluated 81 patients diagnosed with AMs (WHO grade II meningioma) who have undergone surgery at the "Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi between January 1, 2010, and December 31, 2019. The recorded data were demographic and imagistic (MRI, contrast-enhanced T1WI). We calculated the tumour volume prior to the surgery and evaluated the tumour recurrence using MRI at 12, 24, 36, 48 and 60 months after the surgery. Results: 50.6% of patients had meningioma volume < 26.4 cm3. Women had larger tumour volumes than men (52.6%). Patients of age ? 60 years old, had tumour volumes ? 26.4 cm3 in 58.5% of cases and meningiomas with volumes ? 26.4 cm3 recurred earlier (p=0.010). Also, patients who had tumour volumes ? 26.4 cm3, had a shorter PFS (40.976 months), compared to patients with tumour volumes < 26.4 cm3, who had better PFS (53.4 months). Conclusions: the tumour volume of AMs ? 26.4 cm3 represents a negative prognostic factor for both early tumour recurrence and reduced PFS.

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Section: The Influence Of Tumor Volume On the Tumor Recurrence Riskmentioning

confidence: 89%

The tumour volume influence on tumour recurrence and progression-free survival in the case of atypical meningiomas

Cucu¹,

Costea²,

Turliuc³

et al. 2020

roneuro

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“…14,21,23 Moreover, radiotherapy/radiosurgery after resection has been reported for large or atypical/anaplastic tumors. 13,16,26 Adjuvant radiotherapy has also been used among patients with spinal meningioma who had a concurrent or previous cranial meningioma. 19 Results from the present study are consistent with the previous literature, showing increased odds of radiation use with tumors that are larger and with borderline or malignant behavior.…”

Section: Discussionmentioning

confidence: 99%

Trends in the utilization of radiotherapy for spinal meningiomas: insights from the 2004–2015 National Cancer Database

Yolcu¹,

Goyal²,

Alvi³

et al. 2019

Neurosurgical Focus

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OBJECTIVERecent studies have reported on the utility of radiosurgery for local control and symptom relief in spinal meningioma. The authors sought to evaluate national utilization trends in radiotherapy (including radiosurgery), investigate possible factors associated with its use in patients with spinal meningioma, and its impact on survival for atypical tumors.METHODSUsing the ICD-O-3 topographical codes C70.1, C72.0, and C72.1 and histological codes 9530–9535 and 9537–9539, the authors queried the National Cancer Database for patients in whom spinal meningioma had been diagnosed between 2004 and 2015. Patients who had undergone radiation in addition to surgery and those who had received radiation as the only treatment were analyzed for factors associated with each treatment.RESULTSFrom among 10,458 patients with spinal meningioma in the database, the authors found a total of 268 patients who had received any type of radiation. The patients were divided into two main groups for the analysis of radiation alone (137 [51.1%]) and radiation plus surgery (131 [48.9%]). An age > 69 years (p < 0.001), male sex (p = 0.03), and tumor size 5 to < 6 cm (p < 0.001) were found to be associated with significantly higher odds of receiving radiation alone, whereas a Charlson-Deyo Comorbidity Index ≥ 2 (p = 0.01) was associated with significantly lower odds of receiving radiation alone. Moreover, a larger tumor size (2 to < 3 cm, p = 0.01; 3 to < 4 cm, p < 0.001; 4 to < 5 cm, p < 0.001; 5 to < 6 cm, p < 0.001; and ≥ 6 cm, p < 0.001; reference = 1 to < 2 cm), as well as borderline (p < 0.001) and malignant (p < 0.001) tumors were found to be associated with increased odds of undergoing radiation in addition to surgery. Receiving adjuvant radiation conferred a significant reduction in overall mortality among patients with borderline or malignant spinal meningiomas (HR 2.12, 95% CI 1.02–4.1, p = 0.02).CONCLUSIONSThe current analysis of cases from a national cancer database revealed a small increase in the use of radiation for the management of spinal meningioma without a significant increase in overall survival. Larger tumor size and borderline or malignant behavior were found to be associated with increased radiation use. Data in the present analysis failed to show an overall survival benefit in utilizing adjuvant radiation for atypical tumors.

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“…In this series, meningiomas were commonly observed in middle-aged (30-55 years old) population with a female predominance (8:1); meanwhile, the reported incidence of meningioma is higher in elderly, with the female:male ratio of 3.5:1 [2], [19], [20]. The previous study indicated that male and convexity meningiomas are the risk factors for having HGM [2], [21]; however, we did not those associations in our series. Together, our findings suggest that Indonesian females possess specific risk factors that might increase the likelihood of having meningioma.…”

Section: Discussionmentioning

confidence: 65%

Correlation of Expression Transforming Growth Factor-Î²1, E-cadherin, and Ki-67 in Meningiomas

Apriyanto¹,

Darwin²,

Arifin³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Meningioma is the most common primary intracranial tumors in adults, accounts for 36% of total intracranial tumors. Obtaining the clinicopathological characteristics of patients with meningioma and investigating, the association between signaling pathways with disease progression could provide a basis for therapeutic development.AIM: This study aims to investigate the expression of transforming growth factor-β1 (TGF-β1), E-cadherin, and Ki-67 in meningiomas.MATERIALS AND METHODS: This study examined the expression levels of E-cadherin, Ki-67, and TGF-β1 with respect to the WHO grade in patients with meningioma. A total of 62 meningioma samples were analyzed. By the WHO criteria, 54 specimens were diagnosed as the WHO Grade 1, 6 as Grade 2, and 2 as Grade 3. Grade 1 was classified as low-grade meningioma, while Grade 2 and Grade 3 were classified as high-grade meningioma (HGM).RESULTS: In this study, the mean age diagnosis was 41.97 ± 9.79 years old, with female: male ratio of 8:1. There was no association between age, sex, and tumor location with the progression of meningioma. Immune-characterization revealed that HGM was associated with the higher number of Ki-67+ cells (p < 0.0001) and lower expression of TGF-β1 and E-cadherin (p < 0.001). The number of Ki-67+ cells was inversely correlated with TGF-β1 and E-cadherin (p < 0.05). TGF-β1 expression was positively correlated with E-cadherin expression (p < 0.0001).CONCLUSION: This study concluded that HGM was highly proliferative (high Ki-67+) and invasive (low E-cadherin), with dysregulated TGF-β1 signaling. In addition, younger age at diagnosis and high female: male ratio in our series suggests that Indonesian females might possess specific risk factors for having meningioma.

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Relationship between tumor location, size, and WHO grade in meningioma

Cited by 133 publications

References 27 publications

The tumour volume influence on tumour recurrence and progression-free survival in the case of atypical meningiomas

The tumour volume influence on tumour recurrence and progression-free survival in the case of atypical meningiomas

Trends in the utilization of radiotherapy for spinal meningiomas: insights from the 2004–2015 National Cancer Database

Correlation of Expression Transforming Growth Factor-Î²1, E-cadherin, and Ki-67 in Meningiomas

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