Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

Begum, Mst Nurun Nahar; Hassan, M Quamrul; Azad, Kishwar

doi:10.3329/bjch.v36i2.13082

Cited by 6 publications

(13 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, in this study, we found a statistically signi cant increase in UC C-peptide levels in infants who developed hypoglycemia when compared to the control group (P value = 0.005), suggesting that Cpeptide can be used as an early predicator for hypoglycemia in IDMs. This nding is comparable with other studies reporting that cord C-peptide levels were inversely related to BG concentrations in the early postnatal period [9,17,18,20]. Furthermore, the increased UC C-peptide level may be associated with infant macrosomia [17,23] and neonatal septal hypertrophic cardiomyopathy [18].…”

Section: Discussionsupporting

confidence: 89%

“…In this study, at least one attack of hypoglycemia within the rst 3 hours of life developed in IDM in about 65.06% neonates. This is comparable to the ndings of a study by Begum et al [9], in which the occurrence of hypoglycemia was 73.3% within the rst 6 hours of life, while in Agrawal et al [10], only 47% of the infants developed hypoglycemia during the rst 2 hours of life. In our study, of a total of 54 patients developing hypoglycemia, most cases were asymptomatic hypoglycemia (96.30%), which is in agreement with the ndings of previous studies.…”

Section: Discussionsupporting

confidence: 88%

“…In our study, the demographic characteristics of the mothers were similar in hypoglycemic and normoglycemic groups, such as maternal age, maternal weight, and type and duration of diabetes, with similar results when compared to Begum et al [9]. In contrast, Agarwal et al [10] who found that IDMs with hypoglycemia had signi cantly longer durations of maternal diabetes.…”

Section: Discussionsupporting

confidence: 85%

“…In our study, of a total of 54 patients developing hypoglycemia, most cases were asymptomatic hypoglycemia (96.30%), which is in agreement with the ndings of previous studies. For example, in a study by Begum et al [9], about 93.3% of the hypoglycemic babies were asymptomatic, while in Agrawal et al [10] and Van Howe et al [11], 100% of the hypoglycemic babies were asymptotic.…”

Section: Discussionmentioning

confidence: 94%

See 3 more Smart Citations

Role of Umbilical Cord C-Peptide Levels in Early Prediction of Hypoglycemia in Infants of Diabetic Mothers

Saber

Magdy

Sadek

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Until now, diabetes during pregnancy has been associated with a high risk of maternal, fetal, and neonatal morbidities and mortalities. The main aim of this study was to evaluate the risk factors of hypoglycemia in infants of diabetic mothers (IDMs) and to study the relationship between umbilical cord (UC) C peptide levels and the risk of developing hypoglycemia.Material and methods: UC blood C-peptide and serial serum blood glucose measurements were done for all included singleton newborns born to diabetic mothers during the study period. Maternal and neonatal data such as gestational age, maternal age, maternal weight, types of diabetics and its control, maternal glycated hemoglobin (HbA1C), birth weight, Apgar score, and neonatal complete blood picture were collected.Results: In total, 83 IDMs met the inclusion criteria. Fifty-four (65.06%) developed hypoglycemia and 29 (34.94%) remained normoglycemic. However, there were no significant differences between hypoglycemic and normoglycemic IDMs in terms of types of maternal diabetics (P value = 0.41), its duration (P value= 0.43). The hypoglycemia peak occurred within the first 3 hours of life, with 33.11 ± 8.84 mg/dl for the hypoglycemia group and 54.10 ± 6.66 mg/dl for the normoglycemic group (P value < 0.0001). Most of the babies had no hypoglycemic manifestation (96.30%). Neonates with hypoglycemia their mothers had poor diabetes control in the last trimester (HbA1C 7.09 ± 0.96) compared to normoglycemic babies (HbA1C 6.11 ± 0.38), (P-value < 0.0001). The mean (SD) of UC C-peptide level in hypoglycemic neonates increased to 1.73 ± 1.07 ng/ml compared to normoglycemic ones with 1.08 ± 0.81 ng/ml (P value = 0.005).Conclusion: Poor diabetes control, especially in the last trimester, is associated with neonatal hypoglycemia. Increased UC C-peptide levels could be used as an early indicator for the risk of developing neonatal hypoglycemia and a predictor for babies need neonatal admission.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 94%

See 2 more Smart Citations

Role of Umbilical Cord C-Peptide Levels in Early Prediction of Hypoglycemia in Infants of Diabetic Mothers

Saber

Magdy

Sadek

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In this study, at least one attack of hypoglycemia within the first 3 h of life developed in IDM in about 65.06% neonates. This is comparable to the findings of a study by Begum et al [ 9 ], in which the occurrence of hypoglycemia was 73.3% within the first 6 h of life, while in Agrawal et al [ 10 ], only 47% of the infants developed hypoglycemia during the first 2 h of life. In our study, of a total of 54 patients developing hypoglycemia, most cases were asymptomatic hypoglycemia (96.30%), which is in agreement with the findings of previous studies.…”

Section: Discussionsupporting

confidence: 90%

Role of umbilical cord C-peptide levels in early prediction of hypoglycemia in infants of diabetic mothers

et al. 2021

View full text Add to dashboard Cite

Background Until now, diabetes during pregnancy has been associated with a high risk of maternal, fetal, and neonatal morbidities and mortalities. The main aim of this study was to evaluate the risk factors of hypoglycemia in infants of diabetic mothers (IDMs) and to study the relationship between umbilical cord (UC) C peptide levels and the risk of developing hypoglycemia. Material and methods UC blood C-peptide and serial serum blood glucose measurements were done for all included singleton newborns born to diabetic mothers during the study period. Maternal and neonatal data such as gestational age, maternal age, maternal weight, types of diabetics and its control, maternal glycated hemoglobin (HbA1C), birth weight, Apgar score, and neonatal complete blood picture were collected. Results In total, 83 IDMs met the inclusion criteria. Fifty-four (65.06%) developed hypoglycemia and 29 (34.94%) remained normoglycemic. However, there were no significant differences between hypoglycemic and normoglycemic IDMs in terms of types of maternal diabetics (P value = 0.41), its duration (P value = 0.43). The hypoglycemia peak occurred within the first 3 h of life, with 33.11 ± 8.84 mg/dl for the hypoglycemia group and 54.10 ± 6.66 mg/dl for the normoglycemic group (P value < 0.0001). Most of the babies had no hypoglycemic manifestation (96.30%). Neonates with hypoglycemia their mothers had poor diabetes control in the last trimester (HbA1C 7.09 ± 0.96%) compared to normoglycemic babies (HbA1C 6.11 ± 0.38%), (P-value < 0.0001). The mean (SD) of UC C-peptide level in hypoglycemic neonates increased to 1.73 ± 1.07 ng/ml compared to normoglycemic ones with 1.08 ± 0.81 ng/ml (P value = 0.005). Conclusion Poor diabetes control, especially in the last trimester, is associated with neonatal hypoglycemia. Increased UC C-peptide levels could be used as an early indicator for the risk of developing neonatal hypoglycemia and a predictor for babies need neonatal admission.

show abstract

The relationship between neonatal hypoglycaemia and cord blood C‐peptide levels in neonates of birthing individuals with type 1 diabetes

Aharon‐Hananel,

Dori‐Dayan,

Zemet

et al. 2023

Diabetes Metabolism Res

View full text Add to dashboard Cite

IntroductionNeonates of individuals with type 1 diabetes (T1D) are at increased risk of neonatal hypoglycaemia. It is hypothesised that this is a result of birthing‐individual hyperglycaemia and subsequent foetal hyperinsulinemia.AimsTo test for association between clinically significant neonatal hypoglycaemia (requiring intravenous glucose treatment) and cord‐blood c‐peptide (CBCP) concentrations in birthing‐individuals with T1D.Materials and MethodsThis is a prospective cohort study of individuals with T1D followed at a single tertiary centre. Clinical variables and glucose control during pregnancy were recorded. Cord‐blood was collected and CBCP concentrations determined. The correlation between clinically significant neonatal hypoglycaemia and CBCP concentrations was determined.ResultsFifty‐four pregnant individuals and their newborns were included in the study. Individuals to neonates who experienced hypoglycaemia had longer diabetes duration (19 vs. 13 years, respectively, p = 0.023), higher HbA1c at conception (7.3 [6.3–8.8] vs. 6.5 [6.0–7.0], respectively, p = 0.042) and higher rates of caesarian section (73.3% vs. 28.2%, respectively, p = 0.005) than individuals to those who did not. CBCP levels were significantly higher in neonates with clinically significant neonatal hypoglycaemia as compared to those who did not experience hypoglycaemia (3.3 mcg/L vs. 1.9 mcg/L, respectively, p = 0.002). After adjustment for possible confounders, every 1 unit higher in CBCP level was associated with a 1.46 (1.02–2.09, p = 0.035)—fold greater risk for neonatal hypoglycaemia. No significant differences were observed in either birthing individual complications or glucose control indices during pregnancy between the two groups.ConclusionsIn neonates of individuals with T1D, higher CBCP levels are an independent risk factor for clinically significant neonatal hypoglycaemia.

show abstract

Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

Cited by 6 publications

References 25 publications

Role of Umbilical Cord C-Peptide Levels in Early Prediction of Hypoglycemia in Infants of Diabetic Mothers

Role of Umbilical Cord C-Peptide Levels in Early Prediction of Hypoglycemia in Infants of Diabetic Mothers

Role of umbilical cord C-peptide levels in early prediction of hypoglycemia in infants of diabetic mothers

The relationship between neonatal hypoglycaemia and cord blood C‐peptide levels in neonates of birthing individuals with type 1 diabetes

Contact Info

Product

Resources

About