Relationship between Uric Acid and Subtle Cognitive Dysfunction in Chronic Kidney Disease

Afsar, Barış; Elsürer, Rengin; Covic, Adrian; Johnson, Richard J.; Kanbay, Mehmet

doi:10.1159/000329097

Cited by 50 publications

(48 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our finding that uric acid relates to worse cognition is supported by most studies [7,24,29,30]. Moreover, of all cognitive domains investigated, we found strongest associations for information-processing speed and executive function.…”

Section: Discussionsupporting

confidence: 88%

The Relation of Uric Acid to Brain Atrophy and Cognition: The Rotterdam Scan Study

Verhaaren¹,

Vernooij²,

Dehghan³

et al. 2013

Neuroepidemiology

View full text Add to dashboard Cite

Background: Uric acid has been associated with focal vascular brain disease. However, it is unknown whether uric acid also relates to global brain changes such as brain atrophy. We therefore studied the relation of uric acid to brain atrophy and whether this is accompanied by worse cognitive function. Methods: In 814 persons of the population-based Rotterdam Study (mean age 62.0 years), we studied the relation of uric acid levels to brain tissue atrophy and cognition using linear regression models adjusted for age, sex and putative confounders. Brain atrophy was assessed using automated processing of magnetic resonance imaging. Cognition was assessed using a validated neuropsychological test battery and we computed compound scores of cognitive domains. Results: Higher uric acid levels were associated with white matter atrophy [difference in Z-score of white matter volume per standard deviation increase in uric acid: -0.07 (95% CI: -0.12; -0.01)], but not with gray matter atrophy. This was particularly marked when comparing hyperuricemic to normouricemic persons [Z-score difference: -0.27 (-0.43; -0.11)]. Worse cognition was primarily found in persons with hyperuricemia [-0.28 (-0.48; -0.08)]. Conclusions: Hyperuricemia is related to white matter atrophy and worse cognition.

show abstract

Section: Discussionsupporting

confidence: 88%

The Relation of Uric Acid to Brain Atrophy and Cognition: The Rotterdam Scan Study

Verhaaren¹,

Vernooij²,

Dehghan³

et al. 2013

Neuroepidemiology

View full text Add to dashboard Cite

show abstract

“…Chronic kidney disease is an independent risk factor for cognitive dysfunction and dementia [19]. The findings in the present study are supported by previous studies [18,20,21].…”

Section: Discussionsupporting

confidence: 92%

Risk factors associated with abnormal cognition in Japanese outpatients with diabetes, hypertension or dyslipidemia

et al. 2014

View full text Add to dashboard Cite

Aims According to the recent increase in life expectancy in patients with diabetes, the incidence of dementia with diabetes is increasing drastically in Japan. However, the number of studies on the prevalence of abnormal cognition and the associated risk factors in a large number of outpatients with diabetes in a primary care setting is very limited. Methods The Mini-Mental State Examination (MMSE) test was performed in 1,449 outpatients aged C50 years with diabetes, hypertension or dyslipidemia (126 without and 1,323 with diabetes). Prevalence of abnormal cognition defined as an MMSE score \24 and the associated risk factors were explored. Results Prevalence of abnormal cognition was 5.8 % in total, and was 8.3 % in outpatients aged C65 years with diabetes. Logistic regression analysis after adjustment for age, sex, BMI and smoking indicated that abnormal cognition was associated with lower serum albumin and higher uric acid levels in all subjects. In subjects with diabetes, in addition to the associations with serum albumin and uric acid levels, lower renal function, retinopathy, use of insulin and a-glucosidase inhibitor, and non-use of pioglitazone and metformin were significantly associated with abnormal cognition independent of the effect of duration of diabetes, hypertension, dyslipidemia, and history of coronary heart disease and stroke. Conclusions Because of the higher prevalence of abnormal cognition in aged outpatients with diabetes found in primary care practice and significant associations with serum albumin, uric acid, renal function, retinopathy and antidiabetic drugs, there is a need for early diagnosis and strategies against dementia.

show abstract

“…A study by Schretlen et al reported a 2.7-5.9 increased risk of worse results in tests investigating executive functions such as processing speed, verbal memory, and working memory among elderly residents in a nursing home with moderate elevation of uric acid levels 40 . Similar findings were reported in a study on patients with chronic kidney disease 41 , and in the large (n ¼ 1016) cross-sectional InChianti study 42 . In apparent contrast to these pieces of evidence, some studies do not seem to support the hypothesis of the harmfulness of uric acid with regard to cognitive functions.…”

Section: Serum Uric Acid and Dementiasupporting

confidence: 88%

The management of hyperuricemia with urate deposition

Desideri

Puig

Richette

2015

Current Medical Research and Opinion

View full text Add to dashboard Cite

Recent epidemiological data suggest a progressive increase of serum levels of uric acid worldwide. This rise in the prevalence of hyperuricemia may be related to the epidemic diffusion of overweight and obesity as well as the shifts in diet with increased consumption of foods rich in purines, alcoholic consumption, and soft drinks sweetened with fructose. The rise in serum uric acid levels worldwide may be regarded as leading an increased risk for gout and other systemic diseases, especially in the cardio-renal system. Therefore, careful management of hyperuricemia with urate deposition is crucial to prevent or even treat those systemic diseases. Despite this, hyperuricemia and gout often remain untreated. This paper reviews current evidence on the management of hyperuricemia with urate deposition, with a focus on its most controversial aspects. This review is based on a PubMed/Embase database search for articles on hyperuricemia and its impact on cardiovascular and renal function.

show abstract

Relationship between Uric Acid and Subtle Cognitive Dysfunction in Chronic Kidney Disease

Cited by 50 publications

References 87 publications

The Relation of Uric Acid to Brain Atrophy and Cognition: The Rotterdam Scan Study

The Relation of Uric Acid to Brain Atrophy and Cognition: The Rotterdam Scan Study

Risk factors associated with abnormal cognition in Japanese outpatients with diabetes, hypertension or dyslipidemia

The management of hyperuricemia with urate deposition

Contact Info

Product

Resources

About