Relationship between Urinary Bisphenol A Levels and Diabetes Mellitus

Shankar, Anoop; Teppala, Srinivas

doi:10.1210/jc.2011-1682

Cited by 249 publications

(162 citation statements)

References 21 publications

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“…In the present study, we first demonstrated that long-term oral exposure to BPA induced glucose intolerance after the neonatal period by increasing insulin resistance in a manner that was not related to b cell dysfunction. These findings are consistent with previously published epidemiologic data (Lang et al 2008, Shankar & Teppala 2011, Wang et al 2012 and animal studies (Alonso-Magdalena et al 2006, Wei et al 2011, Batista et al 2012). In two large epidemiologic studies, urinary BPA level was positively associated with type 2 diabetes mellitus (Shankar & Teppala 2011) and with obesity and insulin resistance (Wang et al 2012).…”

Section: Discussionsupporting

confidence: 93%

“…However, recent epidemiologic evidence has also implicated BPA in cardiovascular disease, type 2 diabetes, and obesity: increasing serum or urine BPA levels have been positively associated with diabetes mellitus (Lang et al 2008, Shankar & Teppala 2011, cardiovascular disease (Lang et al 2008), obesity, and insulin resistance (Wang et al 2012). Several possible mechanisms have been suggested by animal and in vitro studies, yet whether BPA causes insulin resistance or diabetes is still controversial.…”

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confidence: 99%

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Long-term oral exposure to bisphenol A induces glucose intolerance and insulin resistance

Moon¹,

Jeong²,

Oh³

et al. 2015

Journal of Endocrinology

107

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Bisphenol A (BPA) is a widely used endocrine disruptor. Recent epidemiologic results have suggested an association between exposure to BPA and cardiovascular disease, type 2 diabetes, and obesity. We investigated the in vivo effects of long-term oral exposure to BPA on insulin resistance and glucose intolerance. In the present study, 4-to 6-week-old male mice on a high-fat diet (HFD) were treated with 50 mg/kg body weight per day of BPA orally for 12 weeks. Long-term oral exposure to BPA along with an HFD for 12 weeks induced glucose intolerance in growing male mice. Intraperitoneal glucose tolerance tests showed that the mice that received an HFD and BPA exhibited a significantly larger area under the curve than did those that received an HFD only (119.9G16.8 vs 97.9G18.2 mM/min, PZ0.027). Body weight, percentage of white adipose tissue, and percentage of body fat did not differ between the two groups of mice. However, treatment with BPA reduced Akt phosphorylation at position Thr308 and GSK3b phosphorylation at position Ser9 in skeletal muscle. BPA tended to decrease serum adiponectin levels and to increase serum interleukin 6 and tumor necrosis factor a, although these findings were not statistically significant. Treatment with BPA did not induce any detrimental changes in the islet area or morphology or the insulin content of b cells. In conclusion, long-term oral exposure to BPA induced glucose intolerance and insulin resistance in growing mice. Decreased Akt phosphorylation in skeletal muscle by way of altered serum adipocytokine levels might be one mechanism by which BPA induces glucose intolerance.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Long-term oral exposure to bisphenol A induces glucose intolerance and insulin resistance

Moon¹,

Jeong²,

Oh³

et al. 2015

Journal of Endocrinology

107

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“…There is increasing concern regarding the adverse health effects of BPA on children, given the link between higher levels of urinary BPA and an elevated risk of obesity, type 2 diabetes, and cardiovascular disease based on cross-sectional studies conducted in adults. [1][2][3] Moreover, studies have shown higher urinary concentrations of BPA in children and adolescents compared with adults. 4 Manufacturers have been voluntarily recalling BPA products due to suspicion about the toxic effects on children and other vulnerable populations.…”

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confidence: 99%

Bisphenol A and Chronic Disease Risk Factors in US Children

Eng¹,

Lee²,

Gebremariam³

et al. 2013

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Bisphenol A (BPA) is a known endocrine disruptor found in many products with which children come into contact. Although BPA in adults is associated with obesity, diabetes, and cardiovascular disease, little is known about its effects in children. WHAT THIS STUDY ADDS:This study found that higher BPA levels are associated with obesity and abnormal waist circumferenceto-height ratio in children. abstract OBJECTIVE: To evaluate the relationship between urinary bisphenol A (BPA) levels and measures of adiposity and chronic disease risk factors for a nationally representative US pediatric sample. METHODS:We used the NHANES 2003-2010 to evaluate cross-sectional associations between urinary BPA and multiple measures of adiposity, cholesterol, insulin, and glucose for children aged 6 to 18 years, adjusting for relevant covariates (eg, demographics, urine creatinine, tobacco exposure, and soda consumption). RESULTS:We found a higher odds of obesity (BMI $95th percentile) with increasing quartiles of BPA for quartiles 2 vs 1 (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.17-2.60, P = .008), 3 vs 1 (OR 1.64, 95% CI 1.09-2.47, P = .02), and 4 vs 1 (OR 2.01, 95% CI 1.36-2.98, P = .001). We also found a higher odds of having an abnormal waist circumference-to-height ratio (quartiles 2 vs 1 [OR 1.37, 95% CI 0.98-1.93, P = .07], 3 vs 1 [OR 1.41, 95% CI 1.07-1.87, P = .02], and 4 vs 1 [OR 1.55, 95% CI 1.12-2.15, P = .01]). We did not find significant associations of BPA with any other chronic disease risk factors.CONCLUSIONS: Higher levels of urinary BPA were associated with a higher odds of obesity (BMI .95%) and abnormal waist circumference-to-height ratio. Longitudinal analyses are needed to elucidate temporal relationships between BPA exposure and the development of obesity and chronic disease risk factors in children. Pediatrics 2013;132:e637-e645 AUTHORS:

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“…37 The range of BPA levels found in humans is from 0.7 to 20 nM. 37,38 To support the evidence that BPA may be a risk for the development of diabetes it is critical to study its effect on human tissues involved in glucose and lipid metabolism, including the endocrine pancreas which is key in glucose homeostasis. The islet of Langerhans is the physiological unit of the endocrine pancreas; it is a group of 1500-3000 cells of five different types and the most abundant are bcells.…”

Section: Bisphenol a As An Endocrine Disruptormentioning

confidence: 99%

Use of polycarbonate plastic products and human health

Srivastava

Godara

2013

Int J Basic Clin Pharmacol

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As plastic and plastic products are being used in day to day at the cost of environment pollution, the human and wild life health and has become a global concern. Researchers found link between abnormal liver enzymes in the people and Bisphenol-A (BPA). Changes in insulin resistance, reproduction system, cardiovascular and brain function are also reported. BPA is used in the production of epoxy resins, polycarbonate resins, and polyester resins. BPA can leach out of certain plastic products including variety of modern goods, reusable food storage containers, eyeglass lenses, white dental fillings, sealants, medical equipments etc. In the body, BPA behaves as an estrogen receptor agonist and mimics estrogen hormone. Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. Children and unborn and new born babies are at high risk of unwanted effects of BPA. Children suffer from chronic exposure to bisphenol A with manifestation of gastrointestinal problems, adrenal stress, immune dysfunction, toxic over load and neurological disorders. Some study in Japan has observed that more BPA can leach from polycarbonate products that have been scratched or is more than 4 years old or used bottles that have been subjected to bottle brushing or dishwashing and sterilization. People exposed to higher levels of BPA due to use of plastic food and beverages containers are more likely to develop cardiovascular diseases, diabetes and metabolic disorder. Recent studies have suggested that BPA exposure may have a role in the development of weight gain, insulin resistance, pancreatic endocrine dysfunction, thyroid hormone disruption, and several other mechanisms involved in the development of diabetes. Urinary BPA levels are found to be associated with diabetes mellitus independent of traditional diabetes risk factors. There is a concern of exposure of BPA to pregnant women that can affect the development of offspring in the womb. It is considered that women may be placing their fetuses at the risk by having dental sealants applied during pregnancy. Public should be educated about the use of plastic and plastic products which can prove to be hazardous and risk factor to many health problems of human and wild life. [Int J Basic Clin Pharmacol 2013; 2(1.000): 12-17

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Relationship between Urinary Bisphenol A Levels and Diabetes Mellitus

Abstract: Urinary BPA levels are found to be associated with diabetes mellitus independent of traditional diabetes risk factors. Future prospective studies are needed to confirm or disprove this finding.

Cited by 249 publications

References 21 publications

Long-term oral exposure to bisphenol A induces glucose intolerance and insulin resistance

Long-term oral exposure to bisphenol A induces glucose intolerance and insulin resistance

Bisphenol A and Chronic Disease Risk Factors in US Children

Use of polycarbonate plastic products and human health

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