Relationship Between Urinary Hydroxyproline and Growth*

Jasin, Hugo E.; Fink, Chester W.; Wisf, W.; Ziff, Morris

doi:10.1172/jci104650

Cited by 185 publications

(55 citation statements)

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“…Disorders in which rates of urinary excretion of hydroxyproline are depressed include malnutrition, hypothyroidism and dwarfism, whether of pituitary or other nature, and infantile protein-calorie malnutrition [6,7,11,13,17,181. Disorders associated with increased rates of urinary excretion of hydroxyproline include hyperthyroidism, malabsorption syndromes, rickets and vitamin D-resistant rickets.…”

Section: Commentmentioning

confidence: 99%

“…A numtively great. In view of this considerable contribution ber of studies have suggested that rate of urinary excreof newly formed collagen to urinary excretion of hydrotion of hydroxyproline reflects rate of collagen metaxyproline, it is not surprising that rates of excretion, exbolism [2,6,7,8,9,11,13,15,17,18, 191. Studies of pressed as milligrams/day, have generally been reporthydroxyproline excretion may therefore be clinically ed to be somewhat greater in children than in adults.…”

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Urinary Excretion of Endogenous Hydroxyproline by Normal Male Infants

et al. 1967

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ExtractRates of urinary excretion of total hydroxyproline by 38 normal fullsize male infants were determined on 176 occasions. Each urine collection period was 72 hours. When the period of urine collection was begun between the fourth and eighth day of life, mean rate of excretion was 30.6 mg/day (standard deviation 6.9 mglday). Maximal rates of urinary excretion were observed between 21 and 60 days of age (mean: 48.1 mglday; standard deviation 9.7 mg/day). Between 121 and 582 days of age, mean rate of excretion had decreased slightly to 43 mglday.Eleven infants were each studied on at least five occasions between 20 and 120 days of age. Mean rate of urinary excretion of hydroxyproline by each infant was shown to be significantly correlated with rate of gain in length but not with rate of change in weight or surface area. SpeculationDuring normal infancy it seems probable that a major proportion of the hydroxyproline excreted in the urine is derived from collagen of bone. Rate of excretion probably parallels rate of bone growth. Thus, any disorder that depresses the normal rate of linear growth is likely to result in sharp diminution of urinary excretion of hydroxyproline. Such a biochemical index of growth may be clinically useful. Introductionuseful and may contribute to our understanding of growth. The nonessential amino acid, hydroxyproline, accounts Newly formed collagen is soluble in neutral salt solufor about 13 % by weight of collagen and about 1.5 % tions and is metabolically quite active, while mature colby weight of elastin [18]. Because hydroxyproline is not lagen is insoluble and metabolically relatively inert. Alfound in other body tissues and because the amount of though newly formed collagen accounts for only a small collagen in the body is so much greater than the amount percentage of total body collagen, its contribution to of elastin, urinary excretion of endogenous hydroxyurinary excretion of endogenous hydroxyproline is relaproline is derived almost entirely from collagen. A numtively great. In view of this considerable contribution ber of studies have suggested that rate of urinary excreof newly formed collagen to urinary excretion of hydrotion of hydroxyproline reflects rate of collagen metaxyproline, it is not surprising that rates of excretion, exbolism [2,6,7,8,9,11,13,15,17,18, 191. Studies of pressed as milligrams/day, have generally been reporthydroxyproline excretion may therefore be clinically ed to be somewhat greater in children than in adults.

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Section: Commentmentioning

confidence: 99%

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Urinary Excretion of Endogenous Hydroxyproline by Normal Male Infants

et al. 1967

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“…proline during infancy, childhood and adolescence has been defined and it has been shown that during periods The rate of urinary excretion of endogenous hydroxy-of rapid linear growth, the amount of total hydroxyproiine, both free and in peptide form, is related to the proline excreted increases [8,9,26]. There is little inmetabolic state and total mass of body collagen [2, 13, formation, however, about hydroxyproiine excretion 21].…”

Section: Introductionmentioning

confidence: 99%

Excretion of Hydroxyproline in Urine by Premature and Normal Full-Term Infants and Those with Intrauterine Growth Retardation During the First Three Days of Life

Younoszai

Haworth

1968

Pediatr Res

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ExtractThe mean daily urinary excretion of hydroxyproiine on the first day of life was 4.4 mg/24 h for 50 fullterm normal infants, 3.5mg/24hfor 17 full-term infants with intrauterine growth retardation (IUGR) and 5.5 mg/24 h for 17 premature infants. The differences were not statistically significant. On the third day of life, all infants excreted significantly higher amounts of hydroxyproiine in their urine. The mean amount excreted by full-term normal infants and by premature infants was about the same, 9.9 mg/24 h and 9.6 mg/24 h, respectively, significantly more than that excreted by IUGR infants, 7.0 mg/24 h.Fifteen full-term normal infants fed a soya formula for the first week of life excreted almost the same amount of endogenous creatinine in the urine on the first, third and seventh day of life. The means in mg/24 h were 24.2, 24.3 and 22.5, respectively. The hydroxyproiine to creatinine ratio doubled on the third day of life. SpeculationThe increase in the amount of hydroxyproiine excreted in urine during the first few days of life may prove to be of value in assessing normal and abnormal rates of perinatal growth. Measurements of the amount of hydroxyproiine in urine may provide a good index of perinatal growth, and the rapid increase in excretion soon after birth seems to indicate the initiation of a phase of rapid growth. Introductionproline during infancy, childhood and adolescence has been defined and it has been shown that during periods The rate of urinary excretion of endogenous hydroxy-of rapid linear growth, the amount of total hydroxyproiine, both free and in peptide form, is related to the proline excreted increases [8,9,26]. There is little inmetabolic state and total mass of body collagen [2, 13, formation, however, about hydroxyproiine excretion 21]. A major part of body collagen is contained in bone, during the first few days of life. The purpose of this and the rate of turnover of collagen in bone exceeds study was to establish for the normal full-term infants that in other tissues [19]. It has been assumed, there-the hydroxyproiine excretion in urine during the first fore, that urinary excretion of hydroxyproiine mainly three days of life and to compare these values with those reflects the rate of metabolism of collagen in bone [5, found in patients with intrauterine growth retardation 7,10,11,18]. The normal range of urinary hydroxy-(IUGR) and in premature infants.

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“…The excretion o f total hydroxyproline (THP) is greater in normal children than in adults (Prockop & Kivirikko 1967) and it increases with increasing growth rate (Jasin et al 1962, Jones et al 1964, Smiley & Ziff 1964. The higher concentration of THP found in the urine of IS patients could be caused by an accelerated growth (Zorab et al 1971).…”

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confidence: 99%