Relationship between vascular densities of choriocapillaris and the whole choroid using OCTA

Bartol-Puyal, Francisco de Asís; Isanta, Carlos; Calvo, Pilar; Ruiz-Moreno, Ó.; Júlvez, Luis Pablo

doi:10.1007/s10792-020-01500-7

Cited by 9 publications

(8 citation statements)

References 29 publications

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“…18 We previously compared VD of CC and the whole choroid, and found that foveal VD was always higher than in parafovea. 16 Another explanation may be the difference in methods used in previous studies. Our findings are in line with studies using similar methods such as that proposed by Zhang et al who found that the lobular pattern of the CC becomes more compact toward the fovea.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15] As far as we know, CC thickness has not been mapped yet, and its VD has only been mapped in detail in a previous article of ours. 16 There is a difference between studies analysing CC VD and previous histological studies. 17,18 Common validated methods include measuring flow void areas in horizontal OCT slabs, and automatic VD measurements in ETDRS grid.…”

Section: Introductionmentioning

confidence: 99%

“…12–15 As far as we know, CC thickness has not been mapped yet, and its VD has only been mapped in detail in a previous article of ours. 16…”

Section: Introductionmentioning

confidence: 99%

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Mapping of choriocapillaris vascular density in young and aged healthy subjects

Bartol-Puyal

Isanta

Calvo

et al. 2021

European Journal of Ophthalmology

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Purpose To compare macular vascular density (VD) of the choriocapillaris (CC) between young and aged healthy individuals. Methods A cross-sectional study was performed enrolling young and senior healthy individuals of Caucasian race and an axial length (AL) lower than 26 mm, and without systemic or ophthalmological diseases. CC VD was imaged with DRI Triton OCTA using a 6 × 6 mm macular analysis. Internal software delimited CC boundaries and gave colour pictures, which were analysed and codified into numbers, and a grid of 30 × 30 VD values was obtained. Two-dimension (2D) and three-dimension (3D) representations were created. Results 53 eyes of 53 young healthy individuals and 30 eyes of 30 senior healthy individuals were enrolled. Mean age was 27.17 ± 3.90 years, and 67.00 ± 7.41 years, respectively (p < 0.001). There were no differences in intraocular pressure (IOP) or AL (23.73 ± 0.79 mm, 23.18 ± 0.80 mm, respectively, p = 0.24). There were differences in foveal VD and in temporal perifoveal macula, but not in nasal perifoveal macula. Foveal VD was the highest in both groups. Conclusions Foveal CC VD has been found to be considerably high with this method, and it is the area which most decreases with age. Nasal perifoveal VD is not reduced in older individuals. These outcomes are opposite to other studies using different methods but they are in line with previous histological findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mapping of choriocapillaris vascular density in young and aged healthy subjects

Bartol-Puyal

Isanta

Calvo

et al. 2021

European Journal of Ophthalmology

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“…Exclusion criteria included: (1) complications from other fundus diseases, such as macular hole, diabetic retinopathy, and pathological myopia, (2) macular edema secondary to retinal vascular diseases, (3) choroidal tumors, including metastatic carcinoma, melanoma, and others, (4) previous vitreoretinal surgery, (5) serious systemic organic diseases or inability to tolerate examination, (6) phakia or intraocular lens eyes, (7) serious anterior segment disorders, such as cataracts and keratopathy, affecting the fundus image quality; OCT Scans with low quality(<40/100) were excluded from the study [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Characterization of Choroidal Morphology and Vasculature in the Phenotype of Pachychoroid Diseases by Swept-Source OCT and OCTA

Qiu

Zhang

et al. 2022

JCM

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The objective of this study was to characterize the choroidal morphology and vasculature in pachychoroid diseases (PCD). A total of 49 eyes with polypoidal choroidal vasculopathy (PCV), 43 eyes with neovascular age-related macular degeneration (nAMD), and 50 eyes with central serous chorioretinopathy (CSC), along with 80 healthy eyes, were enrolled in this nested case-control study. The swept-source optical coherent tomography (OCT), OCT angiography, and En face images were quantitatively analyzed. Multivariate logistic regression models showed that older age and increased vessel density (VD) in the choriocapillaris (CC) layer were independent risk factors for both PCV (page < 0.001, pVD = 0.004), and nAMD (page < 0.001, pVD = 0.005). Decreased VD in the Sattler’s layer was an independent risk factor for PCV (p = 0.014). Increased VD in the Haller’s layer was an independent risk factor for CSC (p = 0.001). The proportion of the diffuse type of collateral circulation in the Sattler’ layer in CSC group was significantly higher than in the other three groups (p < 0.001). We concluded that the involvement of the blood flow in the CC, Haller’s, and Sattler’s layers are differently affected in CSC, nAMD, and PCV eyes, indicating the different pathological mechanism underlying the phenotype of PCD. The age-dependent establishment of collateral circulation in the Sattler’s layer may play a compensatory role regarding ischemic injury in the development of PCD.

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“…The measurement position was always centered at the fovea without any rotation, comprising 9 subfields (superotemporal, upper, superonasal, temporal, central, nasal, inferotemporal, lower, inferonasal regions), considering the segmental nature of the choroidal vasculature and vortex veins [44][45][46][47] . (Fig.…”

Section: Methodsmentioning

confidence: 99%

Quantitative analysis of choroidal vasculature in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography angiography

Zeng

Yao

et al. 2022

Sci Rep

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We aimed to quantitatively compare the choroid blood flow and choroid thickness at the periphery among eyes with central serous chorioretinopathy (CSC), fellow eyes and healthy eyes using ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA). Retrospective analysis of 49 patients with CSC (98 eyes, including unaffected fellow eyes) and 49 age and sex matched controls were included. We obtained 3-dimensional data of vertical 20 mm × horizontal 24 mm × scan depth 6 mm, comprising 9 subfields (superotemporal, upper, superonasal, temporal, central, nasal, inferotemporal, lower, inferonasal regions). CSC eyes presented with greater density of large-vessel choroidal layer in all the 9 subfields compared with controls. Compared with normal eyes, CSC eyes had greater choroidal thickness (superotemporal, upper, superonasal, temporal, central, nasal, inferotemporal, and inferonasal subfields) and choroidal volume (superotemporal, upper, superonasal, temporal, central, and nasal subfields). Compared with control eyes, the choriocapillaris density in the superotemporal, inferotemporal and inferonasal subfields was greater in patients with CSC. Our study may provide further evidence for the congestion of vortex vein in the pathogenesis of CSC. UWF SS-OCTA can be used to evaluate the abnormalities of the choroidal structures even at the periphery in eyes with CSC.

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Relationship between vascular densities of choriocapillaris and the whole choroid using OCTA

Cited by 9 publications

References 29 publications

Mapping of choriocapillaris vascular density in young and aged healthy subjects

Mapping of choriocapillaris vascular density in young and aged healthy subjects

Characterization of Choroidal Morphology and Vasculature in the Phenotype of Pachychoroid Diseases by Swept-Source OCT and OCTA

Quantitative analysis of choroidal vasculature in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography angiography

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