Relationship between viral load, infection‐to‐delivery interval and mother‐to‐child transfer of <scp>anti‐SARS‐CoV</scp>‐2 antibodies

Poon, Liona C.; Leung, Bo Wah; Ma, Teng; Yu, Florrie N. Y.; Kong, Choi Wah; Lo, Takkin; So, Po Lam; Leung, WC; Shu, Wendy; Cheung, KW; Moungmaithong, Sakita; Wang, C. C.

doi:10.1002/uog.23639

Cited by 22 publications

(19 citation statements)

References 5 publications

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“…[7][8][9][10] We previously demonstrated that 75% of pregnant women with laboratory-confirmed SARS-CoV-2 infection were seropositive at delivery. 11 In addition to the strict control measures mentioned above, the low seroprevalence recorded in our study might have been related to undetectable antibody levels at the time of specimen collection-the timing of blood sample collection might not have been compatible with antibody detection. However, this is unlikely to have affected the findings among the large number of pregnant women in this study.…”

Section: Discussionmentioning

confidence: 70%

Effects of strict public health measures on seroprevalence of anti–SARS-CoV-2 antibodies during pregnancy

et al. 2022

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Introduction:A substantial number of people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic throughout the course of infection. Nearly half of pregnant women with coronavirus disease 2019 (COVID-19) are asymptomatic upon diagnosis; these cases are not without risk of maternal morbidity. Here, we investigated the seroprevalence of anti-SARS-CoV-2 antibodies in an unselected sample of pregnant women in Hong Kong.Methods: This prospective cohort study included pregnant women who presented for routine Down syndrome screening (DSS) between November 2019 and October 2020; all women subsequently delivered at the booking hospitals. Serum antibodies against SARS-CoV-2 were analysed using a qualitative serological assay in paired serum samples taken at DSS and delivery for all participants.Results: In total, 1830 women were recruited. Six women (0.33%) were seropositive at the DSS visit; this seropositivity persisted until delivery. Of the six women, none reported relevant symptoms during pregnancy; one reported a travel history before DSS and one reported relevant contact history. The interval between sample collections was 177 days (range, 161-195). Among women with epidemiological risk factors, 1.79% with travel history, 50% with relevant contact history, and 0.77% with community SARS-CoV-2 testing history, were

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Section: Discussionmentioning

confidence: 70%

Effects of strict public health measures on seroprevalence of anti–SARS-CoV-2 antibodies during pregnancy

et al. 2022

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“…The qualitative reporting of SARS-CoV-2 RT-PCR testing as positive or negative is sufficient for diagnosis but it is supplemented by the Ct value, a semi-quantitative value [7] that refers to the number of cycles needed to amplify the viral RNA to a detectable level [12] . This Ct value, together with the time of onset of symptoms will help guide infection control, public health, and occupational health decisions [5] which are essential in the clinical management of COVID-19 patients.…”

Section: Discussionmentioning

confidence: 99%

A dynamic forensic medicine approach: Management of the dead during COVID-19 outbreak in Malaysia

Khoo

Hasmi

Mahmood

et al. 2021

Forensic Science International: Reports

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“…Robust humoral response elicited by SARS-CoV-2 infection and vaccination, and efficient IgG transfer in pregnancy have been widely reported (10,(17)(18)(19)(20)(21). Previous studies indicate that the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein contains multiple conformational neutralizing epitopes (22).…”

Section: Abstract (200 Words)mentioning

confidence: 99%

Neutralizing Antibody Activity Against SARS-CoV-2 Variants in Gestational Age-Matched Mother-Infant Dyads

Matsui

Lin

Prahl

et al. 2021

Preprint

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Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there is limited data comparing vaccine versus infection-induced nAb to COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines were matched with 30 naturally infected women by gestational age of exposure. Neutralization activity against the five SARS-CoV-2 Spike sequences was measured by a SARS-CoV-2 pseudotyped Spike virion assay. Effective nAbs against SARS-CoV-2 were present in maternal and cord plasma after both infection and vaccination. Compared to wild type or Alpha variant Spike, these nAbs were less effective against the Kappa, Delta, and Mu Spike variants. Vaccination during the third trimester induced higher nAb levels at delivery than infection during the third trimester. In contrast, vaccine-induced nAb levels were lower at the time of delivery compared to infection during the first trimester. The transfer ratio (cord nAb level/maternal nAb level) was greatest in mothers vaccinated in the second trimester. SARS-CoV-2 vaccination or infection in pregnancy elicit effective nAbs with differing neutralization kinetics that is impacted by gestational time of exposure. Vaccine induced neutralizing activity was reduced against the Delta, Mu, and Kappa variants.Graphic abstract

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Relationship between viral load, infection‐to‐delivery interval and mother‐to‐child transfer of anti‐SARS‐CoV‐2 antibodies

Cited by 22 publications

References 5 publications

Effects of strict public health measures on seroprevalence of anti–SARS-CoV-2 antibodies during pregnancy

Effects of strict public health measures on seroprevalence of anti–SARS-CoV-2 antibodies during pregnancy

A dynamic forensic medicine approach: Management of the dead during COVID-19 outbreak in Malaysia

Neutralizing Antibody Activity Against SARS-CoV-2 Variants in Gestational Age-Matched Mother-Infant Dyads

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